Fragility of Fermi arcs in Dirac semimetals

We use tunable, vacuum ultraviolet laser-based angle-resolved photoemission spectroscopy and density functional theory calculations to study the electronic properties of Dirac semimetal candidate cubic PtBi${}_{2}$. In addition to bulk electronic states we also find surface states in PtBi${}_{2}$ which is expected as PtBi${}_{2}$ was theoretical predicated to be a candidate Dirac semimetal. The surface states are also well reproduced from DFT band calculations. Interestingly, the topological surface states form Fermi contours rather than double Fermi arcs that were observed in Na$_3$Bi. The surface bands forming the Fermi contours merge with bulk bands in proximity of the Dirac points projections, as expected. Our data confirms existence of Dirac states in PtBi${}_{2}$ and reveals the fragility of the Fermi arcs in Dirac semimetals. Because the Fermi arcs are not topologically protected in general, they can be deformed into Fermi contours, as proposed by [Kargarian {\it et al.}, PNAS \textbf{113}, 8648 (2016)]. Our results demonstrate validity of this theory in PtBi${}_{2}$.Comment: 6 pages, 4 figure

Thalidomide-induced Teratogenesis : History and Mechanisms

Peer reviewedPublisher PD

Interaction of the CERN Large Hadron Collider (LHC) Beam with Carbon Collimators

The LHC will operate at an energy of 7 TeV with a luminosity of 1034cm-2s-1. This requires two beams, each with 2808 bunches. The energy stored in each beam of 362 MJ. In a previous paper the mechanisms causing equipment damage in case of a failure of the machine protection system was discussed, assuming that the entire beam is deflected into a copper target [1, 2]. Another failure scenario is the deflection of beam into carbon material. Carbon collimators and beam absorbers are installed in many locations around the LHC to diffuse or absorb beam losses. Since the collimator jaws are close to the beam, it is very likely that they are hit first when the beam is accidentally deflected. Here we present the results of two-dimensional hydrodynamic simulations of the heating of a solid carbon cylinder irradiated by the LHC beam with nominal parameters, carried out using the BIG-2 computer code [3] while the energy loss of the 7 TeV protons in carbon is calculated using the well known FLUKA code [4]. Our calculations suggest that the LHC beam may penetrate up to about 10 m to 15 m in solid carbon, resulting in a substantial damage of collimators and beam absorbers

Flow Field Evolution of a Decaying Sunspot

We study the evolution of the flows and horizontal proper motions in and around a decaying follower sunspot based on time sequences of two-dimensional spectroscopic observations in the visible and white light imaging data obtained over six days from June~7 to~12, 2005. During this time period the sunspot decayed gradually to a pore. The spectroscopic observations were obtained with the Fabry-P\'{e}rot based Visible-Light Imaging Magnetograph (VIM) in conjunction with the high-order adaptive optics (AO) system operated at the 65 cm vacuum reflector of the Big Bear Solar Observatory (BBSO). We apply local correlation tracking (LCT) to the speckle reconstructed time sequences of white-light images around 600 nm to infer horizontal proper motions while the Doppler shifts of the scanned \FeI line at 630.15 nm are used to calculate line-of-sight (LOS) velocities with sub-arcsecond resolution. We find that the dividing line between radial inward and outward proper motions in the inner and outer penumbra, respectively, survives the decay phase. In particular the moat flow is still detectable after the penumbra disappeared. Based on our observations three major processes removed flux from the sunspot: (a) fragmentation of the umbra, (b) flux cancelation of moving magnetic features (MMFs; of the same polarity as the sunspot) that encounter the leading opposite polarity network and plages areas, and (c) flux transport by MMFs (of the same polarity as the sunspot) to the surrounding network and plage regions that have the same polarity as the sunspot.Comment: 9 pages, 7 figures, The Astrophysical Journal, accepted September, 200

Aptamer Antagonists of Myelin-Derived Inhibitors Promote Axon Growth

Myelin of the adult central nervous system (CNS) is one of the major sources of inhibitors of axon regeneration following injury. The three known myelin-derived inhibitors (Nogo, MAG, and OMgp) bind with high affinity to the Nogo-66 receptor (NgR) on axons and limit neurite outgrowth. Here we show that RNA aptamers can be generated that bind with high affinity to NgR, compete with myelin-derived inhibitors for binding to NgR, and promote axon elongation of neurons in vitro even in the presence of these inhibitors. Aptamers may have key advantages over protein antagonists, including low immunogenicity and the possibility of ready modification during chemical synthesis for stability, signaling, or immobilization. This first demonstration that aptamers can directly influence neuronal function suggests that aptamers may prove useful for not only healing spinal cord and other neuronal damage, but may be more generally useful as neuromodulators

A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia

Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component. 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D, has shown efficacy in animal autoimmune disease models of multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and type I diabetes. However, the side effect of 1,25-(OH)2D3 and its synthetic secosteroidal analogs is hypercalcemia, which is a major impediment in their clinical development for autoimmune diseases. Hypercalcemia develops as a result of the action of VDR agonists on the intestine. Here, we describe the identification of a VDR modulator (VDRM) compound A that was transcriptionally less active in intestinal cells and as a result exhibited less calcemic activity in vivo than 1,25-(OH)2D3. Cytokine analysis indicated that the VDRM not only modulated the T-helper cell balance from Th1 to Th2 effector function but also inhibited Th17 differentiation. Finally, we demonstrate that the oral administration of compound A inhibited the induction and progress of experimental autoimmune encephalomyelitis in mice without causing hypercalcemia

Practical sensorless aberration estimation for 3D microscopy with deep learning

Estimation of optical aberrations from volumetric intensity images is a key step in sensorless adaptive optics for 3D microscopy. Recent approaches based on deep learning promise accurate results at fast processing speeds. However, collecting ground truth microscopy data for training the network is typically very difficult or even impossible thereby limiting this approach in practice. Here, we demonstrate that neural networks trained only on simulated data yield accurate predictions for real experimental images. We validate our approach on simulated and experimental datasets acquired with two different microscopy modalities, and also compare the results to non-learned methods. Additionally, we study the predictability of individual aberrations with respect to their data requirements and find that the symmetry of the wavefront plays a crucial role. Finally, we make our implementation freely available as open source software in Python

Flow-distributed spikes for Schnakenberg kinetics

This is the post-print version of the final published paper. The final publication is available at link.springer.com by following the link below. Copyright @ 2011 Springer-Verlag.We study a system of reaction–diffusion–convection equations which combine a reaction–diffusion system with Schnakenberg kinetics and the convective flow equations. It serves as a simple model for flow-distributed pattern formation. We show how the choice of boundary conditions and the size of the flow influence the positions of the emerging spiky patterns and give conditions when they are shifted to the right or to the left. Further, we analyze the shape and prove the stability of the spikes. This paper is the first providing a rigorous analysis of spiky patterns for reaction-diffusion systems coupled with convective flow. The importance of these results for biological applications, in particular the formation of left–right asymmetry in the mouse, is indicated.RGC of Hong Kon

On the Doppler Shift and Asymmetry of Stokes Profiles of Photospheric FeI and Chromospheric MgI Lines

We analyzed the full Stokes spectra using simultaneous measurements of the photospheric (FeI 630.15 and 630.25 nm) and chromospheric (MgI b2 517.27 nm) lines. The data were obtained with the HAO/NSO Advanced Stokes Polarimeter, about a near disc center sunspot region, NOAA AR 9661. We compare the characteristics of Stokes profiles in terms of Doppler shifts and asymmetries among the three spectral lines, which helps us to better understand the chromospheric lines and the magnetic and flow fields in different magnetic regions. The main results are: (1) For penumbral area observed by the photospheric FeI lines, Doppler velocities derived from Stokes I (Vi) are very close to those derived from linear polarization profiles (Vlp) but significantly different from those derived from Stokes V profiles (Vzc), which provides direct and strong evidence that the penumbral Evershed flows are magnetized and mainly carried by the horizontal magnetic component. (2) The rudimentary inverse Evershed effect observed by the MgI b2 line provides a qualitative evidence on its formation height that is around or just above the temperature minimum region. (3) Vzc and Vlp in penumbrae and Vzc in pores generally approach their Vi observed by the chromospheric MgI line, which is not the case for the photospheric FeI lines. (4) Outer penumbrae and pores show similar behavior of the Stokes V asymmetries that tend to change from positive values in the photosphere (FeI lines) to negative values in the low chromosphere (MgI line). (5) The Stokes V profiles in plage regions are highly asymmetric in the photosphere and more symmetric in the low chromosphere. (6) Strong red shifts and large asymmetries are found around the magnetic polarity inversion line within the common penumbra of the Delta spot. This study thus emphasizes the importance of spectro-polarimetry using chromospheric lines.Comment: 10 pages, 7 figures, accepted to The Astrophysical Journa

A confirmatory factor analysis and validation of the forms of self-criticism/reassurance scale

Objective: Several studies have used the Forms of Self-Criticism/Reassurance Scale (FSCRS; Gilbert, Clarke, Hempel, Miles, & Irons, 2004) when exploring the role of emotion regulation in psychopathology. However, psychometric evaluation of the FSCRS is limited. The present study sought to confirm the factor structure of the FSCRS based on theoretical and empirical grounds in a large sample of the general population. / Method: The FSCRS was completed by a large sample of men and women (N= 1,570) as part of an online survey. The data were randomly split in order to perform both independent exploratory (EFA) and confirmatory factor analyses (CFA). One-, two- and three-factor solutions were examined. / Results: A three-factor model of reassured-self (RS) and the two types of self-criticism, inadequate-self (IS), and hated-self (HS), proved to be the best-fitting measurement model in this sample (χ2= 800.3, df= 148, p < .001; CFI [comparative fit index]= .966, TLI [Tucker Lewis index]= .961, RMSEA [root mean square error of the approximation]= .074). Although very similar to the original questionnaire, there were some differences in terms of the items that were retained. Validity was confirmed with the shortened FSCRS showing the same associations with mood and sex as the original version of the FSCRS. / Conclusion: A three-factor model (RS, IS and HS) provided the best-fitting structure and confirmed the separation of different types of self-criticism. Future research should explore the degree to which these separable aspects of self-criticism are theoretically and clinically meaningful and to identify the role of self-reassurance in ameliorating their effects