5,099 research outputs found
Boundary Peeling: Outlier Detection Method Using One-Class Peeling
Unsupervised outlier detection constitutes a crucial phase within data
analysis and remains a dynamic realm of research. A good outlier detection
algorithm should be computationally efficient, robust to tuning parameter
selection, and perform consistently well across diverse underlying data
distributions. We introduce One-Class Boundary Peeling, an unsupervised outlier
detection algorithm. One-class Boundary Peeling uses the average signed
distance from iteratively-peeled, flexible boundaries generated by one-class
support vector machines. One-class Boundary Peeling has robust hyperparameter
settings and, for increased flexibility, can be cast as an ensemble method. In
synthetic data simulations One-Class Boundary Peeling outperforms all state of
the art methods when no outliers are present while maintaining comparable or
superior performance in the presence of outliers, as compared to benchmark
methods. One-Class Boundary Peeling performs competitively in terms of correct
classification, AUC, and processing time using common benchmark data sets
Flow Field Evolution of a Decaying Sunspot
We study the evolution of the flows and horizontal proper motions in and
around a decaying follower sunspot based on time sequences of two-dimensional
spectroscopic observations in the visible and white light imaging data obtained
over six days from June~7 to~12, 2005. During this time period the sunspot
decayed gradually to a pore. The spectroscopic observations were obtained with
the Fabry-P\'{e}rot based Visible-Light Imaging Magnetograph (VIM) in
conjunction with the high-order adaptive optics (AO) system operated at the 65
cm vacuum reflector of the Big Bear Solar Observatory (BBSO). We apply local
correlation tracking (LCT) to the speckle reconstructed time sequences of
white-light images around 600 nm to infer horizontal proper motions while the
Doppler shifts of the scanned \FeI line at 630.15 nm are used to calculate
line-of-sight (LOS) velocities with sub-arcsecond resolution. We find that the
dividing line between radial inward and outward proper motions in the inner and
outer penumbra, respectively, survives the decay phase. In particular the moat
flow is still detectable after the penumbra disappeared. Based on our
observations three major processes removed flux from the sunspot: (a)
fragmentation of the umbra, (b) flux cancelation of moving magnetic features
(MMFs; of the same polarity as the sunspot) that encounter the leading opposite
polarity network and plages areas, and (c) flux transport by MMFs (of the same
polarity as the sunspot) to the surrounding network and plage regions that have
the same polarity as the sunspot.Comment: 9 pages, 7 figures, The Astrophysical Journal, accepted September,
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Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus
Supported by the Dutch Cancer Society (KWF) and Cancer Research UK (CR-UK). This work was supported by Cancer Research UK (grant number A14895
The time-dependent rearrangement of the epithelial basement membrane in human skin wounds
In 62 human skin wounds (surgical wounds, stab wounds and lacerations after surgical treatment) we analyzed the immunohistochemical localization of collagen IV in the epithelial basement membrane. In 27 of these wounds the distribution of collagen VII, which represents a specific component of the basement membrane of stratified epithelia, was also analyzed. We were able to demonstrate a virtually identical co-distribution of both collagen IV and VII in the wound area with no significant time-dependent differences in the appearance of both collagen types. Fragments of the epithelial basement membrane could be detected in the wound area from as early as 4 days after wounding and after 8 days a complete restitution of the epithelial basement membrane was observed. In all cases with a wound age of more than 21 days the basement membrane was completely reformed over the former lesional area. The period between 8 and 21 days after wounding was characterized by a wide variability ranging from complete restitution to deposition of basement membrane fragments or total lack of the epidermal basement membrane
From Macroscopic to Microscopic: Experimental and Computational Methods to Investigate Bio-tribology
Tribology is an important factor (among other factors) during biological interactions of devices and tissues. The paper discusses how new computational and experimental methods can be used to understand and improve the design and development of medical devices at macro and micro scales to sustain life beyond 50 years. We have used pre-clinical experiments and computational methods to understand interactions between orthopaedic implants at the macro scale. The computational model has been validated with experiments. Now this computational model can predict damage in implants for different patients. One such application was successfully tried and tested in collaboration with University National Autonomous Mexico. This methodology can be used in future to design patient specific, affordable (using 3D printing) and robust implants which will be useful for developing countries like Vietnam, India and Mexico. Improvement of catheter designs is important to reduce damage to the internal tissues while being used for cardiovascular problems. We are developing new experimental techniques (in micro scale) that can be used to understand the interaction of cells with the catheter material. These will help reduce the hospital costs incurred during longer stay of the patients admitted for cardiovascular related problems
Effect of biased noise fluctuations on the output radiation of coherent beat laser
Effect of biased noise fluctuations on the degree of squeezing as well as the
intensity of a radiation generated by a one-photon coherent beat laser is
presented. It turns out that the radiation exhibits squeezing inside and
outside the cavity under certain conditions. The degree of squeezing is
enhanced by the biased noise input significantly in both regions. Despite the
presence of the biased environment modes outside the cavity, the degree of
squeezing outside the cavity can be greater than or equal to or even less than
the cavity radiation depending on the initial preparation of the atomic
superposition and amplitude of the external driving radiation. But the
intensity of the radiation is found to be lesser outside the cavity regardless
of these parameters.Comment: 18 pages, 7 figure
Simulating radiation damage cascades in graphite
Molecular dynamics simulation is used to study radiation damage cascades in graphite. High statistical precision is obtained by sampling a wide energy range (100–2500 eV) and a large number of initial directions of the primary knock-on atom. Chemical bonding is described using the Environment Dependent Interaction Potential for carbon. Graphite is found to exhibit a radiation response distinct from metals and oxides primarily due to the absence of a thermal spike which results in point defects and disconnected regions of damage. Other unique attributes include exceedingly short cascade lifetimes and fractal-like atomic trajectories. Unusually for a solid, the binary collision approximation is useful across a wide energy range, and as a consequence residual damage is consistent with the Kinchin–Pease model. The simulations are in agreement with known experimental data and help to clarify substantial uncertainty in the literature regarding the extent of the cascade and the associated damage
Benefits of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI) in improving lung function and reducing exacerbations in patients with moderate-to-very severe COPD:a pooled analysis of the PINNACLE studies
Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial
BACKGROUND: In the IMPACT trial, single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) reduced moderate/severe exacerbation rates versus FF/VI and UMEC/VI in patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of exacerbations, with a similar safety profile. Research Question Does age have an effect on trial outcomes? STUDY DESIGN AND METHODS: IMPACT was a Phase III, double-blind, 52-week trial. Patients ≥40 years of age with symptomatic COPD and ≥1 moderate/severe exacerbation in the prior year were randomized 2:2:1 to FF/UMEC/VI 100/62.5/25 mcg, FF/VI 100/25 mcg, or UMEC/VI 62.5/25 mcg. Endpoints assessed by age included annual rate of moderate/severe exacerbations, change from baseline (CFB) in trough forced expiratory volume in 1 second (FEV1), proportion of St George's Respiratory Questionnaire (SGRQ) responders (≥4 units decrease from baseline in SGRQ total score) and safety. RESULTS: The intent-to-treat population comprised 10,355 patients; 4724 (46%), 4225 (41%), and 1406 (14%) were ≤64, 65-74, and ≥75 years of age, respectively. FF/UMEC/VI reduced on-treatment moderate/severe exacerbation rates versus FF/VI (% reduction [95% confidence interval (CI)], ≤64 years: 8% [-1, 16], p=0.070; 65-74 years: 22% [14, 29], p<0.001; ≥75 years 18% [3, 31], p=0.021) and versus UMEC/VI (≤64 years: 16% [7, 25], p=0.002; 65-74 years: 33% [25, 41], p<0.001; ≥75 years 24% [6, 38], p=0.012), with greatest rate reduction seen in the 65-74 and ≥75 years subgroups. Post hoc analyses of CFB in trough FEV1, and proportion of SGRQ responders at Week 52 were significantly greater with FF/UMEC/VI than FF/VI or UMEC/VI in all subgroups. No new safety signals were identified. INTERPRETATION: FF/UMEC/VI reduced the rate of moderate/severe exacerbations and improved lung function and health status versus FF/VI and UMEC/VI irrespective of age for most endpoints, with a similar safety profile. CLINICAL TRIAL REGISTRATION: GSK (CTT116855/NCT02164513)
Transversal crack and delamination of laminates using XFEM
This paper offers a new insight into the computational modelling of crack and delamination of carbon fiber composite. Both transversal cracks (intralaminar) and delamination (interlaminar) are modelled with Extended Finite Element Method (XFEM). Constitutive and fracture laws are integrated to model the initiation of crack or delamination, and their subsequent evolution. The study includes the size effect assessment of composite due to the increment of composite thickness. The results are in close agreement between the experimental and analytical data of each specimen modelled based on the size of the carbon fiber composite volume
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