Dual Crosslinked Poly(acrylamide-co-N-vinylpyrrolidone) Microspheres With Re-crosslinking Ability For Fossil Energy Recovery

Microspheres have been proposed to be applied in controlling wastewater production for mature oilfields and migrating leakage for gas and nuclear waste storage. However, it remains challenging for stacked microspheres to maintain strong blocking ability in micron-sized small pores or fractures. In this study, a novel microsphere was developed with comprehensive properties including high deformability and long re-crosslinking time upon tunable swelling ratio for the applications. A dual covalent and physical crosslinking strategy was used to develop novel microspheres reinforced by a hydrogen bond (H-bond, between pyrrole ring and amide group) and coordination bond (between chromium acetate (CrAc) and carboxyl group via hydrolysis process). The microspheres were fabricated via radical suspension copolymerization of acrylamide (AM) and N-vinylpyrrolidone (NVP) in the presence of N, Nʹ-methylene-diacrylamide (MBA) with subsequent introduction of CrAc. MBA induced the strong crosslinking through a chemical covalent bond and H-bond triggered the weak crosslinking which was anticipated to prohibit the hydrolysis of the amide group. The H-bond delayed the formation of CrAc coordination bond by delaying the formation of carboxyl groups, resulting in achieving the re-crosslinking of the microspheres. As a result, the microspheres exhibit the tunable initial size (8–165 μm) and swelling ratio (30–630 μm), with controllable network parameters. The microspheres showed high migration ability (can transport through pores with 1/16 size of microsphere itself), and long re-crosslinking time (up to 16.5 days). The re-crosslinked gel demonstrated dual network structure with districted mesh size ζ distribution

ISPRS International Journal of Geo-Information / Extraction of terraces on the loess plateau from high-resolution DEMs and imagery utilizing object-based image analysis

Terraces are typical artificial landforms on the Loess Plateau, with ecological functions in water and soil conservation, agricultural production, and biodiversity. Recording the spatial distribution of terraces is the basis of monitoring their extent and understanding their ecological effects. The current terrace extraction method mainly relies on high-resolution imagery, but its accuracy is limited due to vegetation coverage distorting the features of terraces in imagery. High-resolution topographic data reflecting the morphology of true terrace surfaces are needed. Terraces extraction on the Loess Plateau is challenging because of the complex terrain and diverse vegetation after the implementation of “vegetation recovery”. This study presents an automatic method of extracting terraces based on 1 m resolution digital elevation models (DEMs) and 0.3 m resolution Worldview-3 imagery as auxiliary information used for object-based image analysis (OBIA). A multi-resolution segmentation method was used where slope, positive and negative terrain index (PN), accumulative curvature slope (AC), and slope of slope (SOS) were determined as input layers for image segmentation by correlation analysis and Sheffield entropy method. The main classification features based on DEMs were chosen from the terrain features derived from terrain factors and texture features by gray-level co-occurrence matrix (GLCM) analysis; subsequently, these features were determined by the importance analysis on classification and regression tree (CART) analysis. Extraction rules based on DEMs were generated from the classification features with a total classification accuracy of 89.96%. The red band and near-infrared band of images were used to exclude construction land, which is easily confused with small-size terraces. As a result, the total classification accuracy was increased to 94%. The proposed method ensures comprehensive consideration of terrain, texture, shape, and spectrum characteristics, demonstrating huge potential in hilly-gully loess region with similarly complex terrain and diverse vegetation covers.(VLID)219512

Downregulation of Brassica napus MYB69 (BnMYB69) increases biomass growth and disease susceptibility via remodeling phytohormone, chlorophyll, shikimate and lignin levels

MYB transcription factors are major actors regulating plant development and adaptability. Brassica napus is a staple oil crop and is hampered by lodging and diseases. Here, four B. napus MYB69 (BnMYB69s) genes were cloned and functionally characterized. They were dominantly expressed in stems during lignification. BnMYB69 RNA interference (BnMYB69i) plants showed considerable changes in morphology, anatomy, metabolism and gene expression. Stem diameter, leaves, roots and total biomass were distinctly larger, but plant height was significantly reduced. Contents of lignin, cellulose and protopectin in stems were significantly reduced, accompanied with decrease in bending resistance and Sclerotinia sclerotiorum resistance. Anatomical detection observed perturbation in vascular and fiber differentiation in stems, but promotion in parenchyma growth, accompanied with changes in cell size and cell number. In shoots, contents of IAA, shikimates and proanthocyanidin were reduced, while contents of ABA, BL and leaf chlorophyll were increased. qRT-PCR revealed changes in multiple pathways of primary and secondary metabolisms. IAA treatment could recover many phenotypes and metabolisms of BnMYB69i plants. However, roots showed trends opposite to shoots in most cases, and BnMYB69i phenotypes were light-sensitive. Conclusively, BnMYB69s might be light-regulated positive regulators of shikimates-related metabolisms, and exert profound influences on various internal and external plant traits

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus

Objectives: Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial. Here, we detail a systematic and structured evidence-based approach to inform consensus decision making to select the first two drugs for evaluation in Motor Neuron Disease-Systematic Multi-arm Adaptive Randomised Trial (MND-SMART: NCT04302870), an adaptive platform trial. We aim to identify and prioritise candidate drugs which have the best available evidence for efficacy, acceptable safety profiles and are feasible for evaluation within the trial protocol. Methods: We conducted a two-stage systematic review to identify potential neuroprotective interventions. First, we reviewed clinical studies in MND, Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and multiple sclerosis, identifying drugs described in at least one MND publication or publications in two or more other diseases. We scored and ranked drugs using a metric evaluating safety, efficacy, study size and study quality. In stage two, we reviewed efficacy of drugs in MND animal models, multicellular eukaryotic models and human induced pluripotent stem cell (iPSC) studies. An expert panel reviewed candidate drugs over two shortlisting rounds and a final selection round, considering the systematic review findings, late breaking evidence, mechanistic plausibility, safety, tolerability and feasibility of evaluation in MND-SMART. Results: From the clinical review, we identified 595 interventions. 66 drugs met our drug/disease logic. Of these, 22 drugs with supportive clinical and preclinical evidence were shortlisted at round 1. Seven drugs proceeded to round 2. The panel reached a consensus to evaluate memantine and trazodone as the first two arms of MND-SMART. Discussion: For future drug selection, we will incorporate automation tools, text-mining and machine learning techniques to the systematic reviews and consider data generated from other domains, including high-throughput phenotypic screening of human iPSCs

An Exploration of Loess Landform Development Based on Population Ecology Method

The study of gully characteristics is one of the most effective ways to explore the loess landform development in the Loess Plateau of China. However, current studies mostly focus on gullies’ overall characteristics and ignore the different composition of the whole gully system. Therefore, a new perspective is provided in this paper for exploring loess landform development from the population characteristics of the gully system. Firstly, different types of gullies were extracted based on DEM and high-resolution images in three sample watersheds, including hillslope ephemeral gully, bank gully and different-level valley gully. Secondly, population characteristics from the amount, length, age structure and convergent relationship were calculated and analyzed by referring to the biological population in ecology. Finally, the development stages of loess landform in three watersheds were explored based on their population characteristics. The results showed that: (1) The population characteristics, including number density, length density, age structure and convergence, were obviously different in three sample watersheds. (2) The development differences of three watersheds were obtained by synthesizing all population characteristics: Linjiajian was the most developed and oldest watershed, followed by Yangjiaju and then Wangjiagou. (3) The comparison based on the existing soil erosion intensity map and predisposing factors proved that the findings of this paper were more reasonable than that of the traditional hypsometric integral. This research provides a new quantitative-based approach to explore the development degree of loess landform from the gully population, and is a beneficial attempt to combine geomorphology and ecology, further supplementing and improving the study of loess landform development

An Exploration of Loess Landform Development Based on Population Ecology Method

The study of gully characteristics is one of the most effective ways to explore the loess landform development in the Loess Plateau of China. However, current studies mostly focus on gullies’ overall characteristics and ignore the different composition of the whole gully system. Therefore, a new perspective is provided in this paper for exploring loess landform development from the population characteristics of the gully system. Firstly, different types of gullies were extracted based on DEM and high-resolution images in three sample watersheds, including hillslope ephemeral gully, bank gully and different-level valley gully. Secondly, population characteristics from the amount, length, age structure and convergent relationship were calculated and analyzed by referring to the biological population in ecology. Finally, the development stages of loess landform in three watersheds were explored based on their population characteristics. The results showed that: (1) The population characteristics, including number density, length density, age structure and convergence, were obviously different in three sample watersheds. (2) The development differences of three watersheds were obtained by synthesizing all population characteristics: Linjiajian was the most developed and oldest watershed, followed by Yangjiaju and then Wangjiagou. (3) The comparison based on the existing soil erosion intensity map and predisposing factors proved that the findings of this paper were more reasonable than that of the traditional hypsometric integral. This research provides a new quantitative-based approach to explore the development degree of loess landform from the gully population, and is a beneficial attempt to combine geomorphology and ecology, further supplementing and improving the study of loess landform development

Progress of Digital Terrain Analysis on Regional Geomorphology in China

Regional geomorphological research is an important part of regional geography research. In recent decades, digital terrain analysis has been widely used in regional geomorphology research. However, due to the limitations of the classic neighborhood analysis algorithm, it is hard to realize the quantitative analysis on the macroscopic morphological features. To solve this problem, Chinese scholars had made a lot of explorations and innovations. An overall review was made in this paper on Chinese scholars' contribution to the DTA research on macro terrain morphology analysis, topographic feature analysis, tupu analysis, landform evolution, landform classification and mapping. The research review shows that Chinese scholars' researches are closely followed by international frontier. The digital terrain analysis in the Qinghai-Tibet Plateau, the Loess Plateau and the southwest karst area highlights the regional characteristics and advantages of geomorphology in China, and has had an important impact in the international academic session

A Collaborative Sensing System for Farmland Water Conservancy Project Maintenance through Integrating Satellite, Aerial, and Ground Observations

More and more attention has been paid to farmland water conservancy project (FWCP) maintenance in China, which can reallocate water resources in a more rational and efficient manner. Compared with the traditional survey such as field survey, FWCP maintenance can be improved efficiently with geospatial technology. To improve the level of FWCP maintenance in China, a collaborative sensing system framework by integrating satellite, aerial, and ground remote sensing is put forward. The structure of the system framework includes three sections, namely the data acquisition, the operational work, and the application and service. Through the construction and operation of such collaborative sensing system, it will break through the limitation of any single remote sensing platform and provide all-around and real-time information on FWCP. The collaborative monitoring schemes for the designed FWCP maintenance can engage ditch riders to maintain more effectively, which will enable them to communicate more specifically with smallholders in the process of irrigation. Only when ditch riders and farmers are fully involved, irrigation efficiency will be improved. Furthermore, the collaborative sensing system needs feasible standards for multi-source remote sensing data processing and intelligent information extraction such as data fusion, data assimilation, and data mining. In a way, this will promote the application of remote sensing in the field of agricultural irrigation and water saving. On the whole, it will be helpful to improve the traditional maintenance problems and is also the guarantee for establishing a long-term scientific management mechanism of FWCP maintenance in developing countries, especially in China

Height estimation from single aerial imagery using contrastive learning based multi-scale refinement network

Height map estimation from a single aerial image plays a crucial role in localization, mapping, and 3D object detection. Deep convolutional neural networks have been used to predict height information from single-view remote sensing images, but these methods rely on large volumes of training data and often overlook geometric features present in orthographic images. To address these issues, this study proposes a gradient-based self-supervised learning network with momentum contrastive loss to extract geometric information from non-labeled images in the pretraining stage. Additionally, novel local implicit constraint layers are used at multiple decoding stages in the proposed supervised network to refine high-resolution features in height estimation. The structural-aware loss is also applied to improve the robustness of the network to positional shift and minor structural changes along the boundary area. Experimental evaluation on the ISPRS benchmark datasets shows that the proposed method outperforms other baseline networks, with minimum MAE and RMSE of 0.116 and 0.289 for the Vaihingen dataset and 0.077 and 0.481 for the Potsdam dataset, respectively. The proposed method also shows around threefold data efficiency improvements on the Potsdam dataset and domain generalization on the Enschede datasets. These results demonstrate the effectiveness of the proposed method in height map estimation from single-view remote sensing images