19 research outputs found
Effect van voermethode en lagere mineralengehalten in het voer op de mineralenuitscheiding en technische resultaten bij vleesvarkens : fase 2: voeren naar de geschatte behoefte aan aminozuren met multifasenvoedering = Effect of feeding method and decreased mineral content in the diet on mineral excretion and performance of growing pigs : phase 2: feeding to the estimated requirement ...
Effect van voermethode en lagere mineralengehalten in het voer op de mineralenuitscheiding en technische resultaten bij vleesvarkens : fase 2: voeren naar de geschatte behoefte aan aminozuren met multifasenvoedering = Effect of feeding method and decreased mineral content in the diet on mineral excretion and performance of growing pigs : phase 2: feeding to the estimated requirement ...
Peptide aldehydes as inhibitors of HIV protease
We have recently shown that alpha-MAPI, a peptidic aldehyde of microbial origin, inhibits the HIV protease with a potency comparable to pepstatin, having, differently from pepstatin, no activity on other aspartic proteases. In this study different peptide derivatives containing a C-terminal aldehyde have been tested to assess the potential of this function for the inhibition of HIV protease. The results of our analysis correspond with the recently published subsite preferences of the viral enzyme, indicating that aldehydes bind to the active site of the HIV protease. Our data suggest that peptide aldehydes can act in their hydrated forms as transition state analogues with the most potent inhibitor having an IC50 of 0.9 microM