The topography of the thoracic and abdominal organs of the Nile crocodile (Crocodylus niloticus)

The pleural cavity of the Nile crocodile is divided into two separate cavities by means of a complete mediastinum. The pleural cavity contains the lungs, while the heart is situated in its own cavity, the pericardial cavity. The pleural cavity is separated from the hepatic coelom, which contains the liver, by the post-pulmonary membrane. The hepatic coelom is separated from the peritoneal cavity by the post-hepatic membrane. The peritoneal cavity contains the abdominal organs.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

Bioactive peptides and serotonin, in the gut endocrine cells of the crocodile, Crocodylus niloticus (Laurenti 1768) : an immunocytochemical study

Little is known about peptide-storing endocrine cells in the gut of the Nile crocodile. As in the case of other reptiles, particularly the alligator, a limited range of peptide-storing cells was found in the gut of the crocodile. They were somatostatin, glucagon, gastrin, neurotensin and pancreatic polypeptide. The topographical distribution of cells immunoreactive to somatostatin and gastrin in the gut of the crocodile is comparable to the situation in the alligator. Glucagon and neurotensin immunoreactive cells have a much wider distribution in the gastrointestinal tract of the crocodile compared to the alligator. Cholecystokinin and bombesin cells previously reported in the small intestine of the alligator were not detected in this study. This is the first report to demonstrate pancreatic polypeptide and serotonin immunoreactivity in the gut of a crocodilian specie.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

A light microscopical study of the intestinal tract of the Nile crocodile (Crocodylus niloticus, Laurenti 1768)

Although the histology of the intestinal tract of Crocodylus niloticus is touched on in overall studies on reptilian intestinal tract, a more comprehensive light microscopical study on this area is lacking. Specimens for histological examination were taken from the duodenum, the jejunum, the ileum and the rectum. The data obtained revealed that the mucosa is thrown into folds and simple, slightly branched tubular intestinal glands. The mucosal folds diminished in height and eventually disappeared upon reaching the ileorectal junction. The epithelium covering the folds and crypts was of the simple columnar type. Clear marginal cells, goblet cells and argentaffin cells were observed throughout the intestinal tract. No Paneth cells were seen in this study. The lamina propria was rich in lymphocytic infiltrations while the muscularis mucosa consisted mainly of an outer longitudinal layer, the inner circular layer being rudimentary or absent. The submucosa was extremely narrow, and the circular and longitudinal layers of the tunica muscularis contained distinct layers of dense fibrous connective tissue. The histology of the intestinal tract of C. niloticus is shown to be in line with the situation in crocodilians and also exhibits a resemblance to that of carnivorous mammals.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

The skull and mandible of the African elephant (Loxodonta africana)

In the present study the bones of the skull, excluding the hyoid apparatus, are described. All the bones are aerated by sinuses. In the occipital bone the squamous part is aerated from the sinus of the parietal bone, the lateral part is aerated from the tympanic bulla and the basal part from the sinus of the basisphenoid bone. Condylar foramens and hypoglossal canals are absent. A small interparietal bone is present at birth. At an early age it fuses with the surrounding cranial bones. The squamous part of the temporal bone lies sagittally in young animals, but moves progressively to a transverse plane as the animals age. A foramen lacerum is represented by jugular and oval foramens and the carotid canal. The body of the basisphenoid bone is excavated by the massive maxillary tuberosity. The latter extends to the oval foramen and contains the developing molar teeth. The ethmoturbinate, nasal and lacrimal bones are exceptionally small. In old bulls the palatine processes of the incisive bones and their sinuses are gradually displaced by the palatine processes of the maxillae. The incisive part of the mandible does not carry any teeth and both lateral and medial mental foramina are present.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn201

Changes in phosphorus status of 'Cripps' Pink' apple trees after application of mulches

The effect of four different mulches on fruit quality was quantified, either directly via mineral nutrient contributions or indirectly, by increasing nutrient uptake efficiency in the soil. We hypothesised that fruit nutrient levels would increase more when an organic mulch, containing nutrients, was applied to the soil, with smaller/no increases when an inorganic mulch was applied to the tree row. In this paper, we concentrate on changes in fruit phosphorus (P) concentrations after application of five treatments: a clean cultivated control, an inorganic woven geotextile fabric, and organic mulches – compost, wood chips and a vermi-castings/ wood chips combination. The trial was conducted on a commercial farm, Lourensford Estate, South Africa, from October 2008 to April 2012 – on an adjacent light, sandy and heavier, sandy-silt soil. Mineral nutrient analyses of the soil, leaves, mulches and fruit were performed. Yield and fruit size were determined. Soil temperatures and soil water status were recorded hourly during the last two seasons. P concentrations did increase chronologically from the soil, then into leaves and then into the fruit after application of mulches that provided additional P to the soil. Sporadic increases in both leaves and fruit occurred, but could not always be related to treatment effects. The significant consistent increase of P levels of the vermi-castings treatment in the heavy soil is likely to be a combination of reduced irrigation volumes, as well as a treatment effect. All mulches resulted in the well-established buffering of soil temperatures, soil water content and percentage soil carbon. Based on results from this study, it is not feasible to apply mulches for the sole purpose to increase P levels in the soil, leaves or fruit of established trees – although increases were noticed from time to time. In addition to water and temperature modifying effects of mulches that would differ between soil textures and depend on the mulch source, increases in P concentrations may result. As yield efficiency is still the primary factor determining income per hectare for the producer, the decrease in yield that resulted from mulching under these conditions, will still outweigh any positive contributions of mulches. It is therefore of utmost importance to first adjust irrigation volumes to a mulch treatment before the advantageous properties of mulching will be of value.Stellenbosch University and HortgroScience.http://www.actahort.orgam201

T-Cell activation: a queuing theory analysis at low agonist density

We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation. We fit our model to four experimentally characterized threshold activation criteria and analyze their specificity and sensitivity: the initial calcium spike, cytotoxicity, immunological synapse formation, and cytokine secretion. Specificity characteristics improve as the time window for detection increases, saturating for time periods on the timescale of downregulation; thus, the calcium spike (30 s) has low specificity but a sensitivity to single-peptide MHC ligands, while the cytokine threshold (1 h) can distinguish ligands with a 30% variation in the complex lifetime. However, a robustness analysis shows that these properties are degraded when the queue parameters are subject to variation—for example, under stochasticity in the ligand number in the cell-cell interface and population variation in the cellular threshold. A time integration of the queue over a period of hours is shown to be able to control parameter noise efficiently for realistic parameter values when integrated over sufficiently long time periods (hours), the discrimination characteristics being determined by the TCR signal cascade kinetics (a kinetic proofreading scheme). Therefore, through a combination of thresholds and signal integration, a T cell can be responsive to low ligand density and specific to agonist quality. We suggest that multiple threshold mechanisms are employed to establish the conditions for efficient signal integration, i.e., coordinate the formation of a stable contact interface

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors