Durability of treatment effects of the Sleep Position Trainer versus oral appliance therapy in positional OSA: 12-month follow-up of a randomized controlled trial

The Sleep Position Trainer (SPT) is a new option for treating patients with positional obstructive sleep apnea (POSA). This study investigated long-term efficacy, adherence, and quality of life during use of the SPT device compared with oral appliance therapy (OAT) in patients with POSA. This prospective, multicenter trial randomized patients with mild to moderate POSA (apnea-hypopnea index [AHI] 5-30/h) to SPT or OAT. Polysomnography was performed at baseline and after 3 and 12 months' follow-up. The primary endpoint was OSA severity; adherence, quality of life, and adverse events were also assessed. Ninety-nine patients were randomized and 58 completed the study (29 in each group). Median AHI in the SPT group decreased from 13.2/h at baseline to 7.1/h after 12 months (P < 0.001); corresponding values in the OAT group were 13.4/h and 5.0/h (P < 0.001), with no significant between-group difference (P = 1.000). Improvements throughout the study were maintained at 12 months. Long-term median adherence was also similar in the two treatment groups; the proportion of patients who used their device for ≥ 4 h for 5 days in a week was 100% in the SPT group and 97.0% in the OAT group (P = 0.598). The efficacy of SPT therapy was maintained over 12 months and was comparable to that of OAT in patients with mild to moderate POSA. Adherence was relatively high, and similar in the two groups. www.clinicaltrials.gov (NCT02045576

Sowing Date Affects Dry Matter Yield of Fodder Beet (\u3ci\u3eBeta vulgaris\u3c/i\u3e L.) Crops and Farm Profitability

Fodder beet (Beta vulgaris L.) is a high yielding and high energy supplementary ruminant feed. Including the crop in a pasture system means loss in production and additional costs during crop establishment, but economic benefits may be recovered with increased seasonal productivity and feed quality. In this study, the Agricultural Production Systems sIMulator was used to estimate herbage production of a typical dairy farm in the Canterbury region of New Zealand based on using a ryegrass (Lolium perenne L.)-clover (Trifolium repens L.) pasture (“Pasture only”) or pasture in combination with fodder beet as winter feed (“Pasture+Fodder beet (FB)”). Mean yields of pasture were used to estimate the potential pasture yield lost from spraying out paddocks 1 month before establishing fodder beet. Fodder beet (‘Rivage’) yields from a 2014 sowing date trial: 19 September (Sep-FB), 17 October (Oct-FB), 17 November (Nov-FB), and 15 December (Dec-FB) were used. Dry matter (DM) yield was determined on 15 June 2015. Yield was 27 t DM/ha for both Sep-FB and Oct-FB and was reduced by 23 and 32% in Nov-FB and Dec-FB, respectively. The total annual yield for “Pasture only” was 16.7 t DM/ha compared with adjusted yield of 29.5, 30.2, 25.7 and 24.9 t DM/ha for “Pasture+Sep-FB”, “Pasture+Oct-FB”, “Pasture+Nov-FB” and “Pasture+Dec-FB”, respectively. Production cost was NZ$0.08/kg DM each for “Pasture+Sep-FB” and “Pasture+Oct-FB”, which was lower than NZ$0.09/kg DM for “Pasture only”. Production costs increased to NZ$0.11/kg DM for “Pasture+Nov-FB” and NZ$0.12/kg DM for “Pasture+Dec-FB”, but revenue from sale of surplus feed partially offset these costs. Our results show that sowing in October was the most profitable option. Yield gains from sowing fodder beet in September are unlikely because of low temperatures limiting crop growth. Delaying sowing can increase production costs and yield penalty, but potential returns are greater, compared with “Pasture only”

Building a corpus of multimodal interaction in your field site

Research on video- and audio-recordings of spontaneous naturally-occurring conversation in English has shown that conversation is a rule-guided, practice-oriented domain that can be investigated for its underlying mechanics or structure. Systematic study could yield something like a grammar for conversation. The goal of this task is to acquire a corpus of video-data, for investigating the underlying structure(s) of interaction cross-linguistically and cross-culturally

Submuscular transposition with musculofascial lengthening for persistent or recurrent cubital tunnel syndrome in 34 patients

The two main surgical options for patients with persistent or recurrent cubital tunnel syndrome are subcutaneous and submuscular transposition. We retrospectively analysed the results of 34 patients with recalcitrant cubital tunnel syndrome who underwent submuscular transposition with musculofascial lengthening at our institutions. Of the 34 patients, 21 improved clinically after submuscular transposition with musculofascial lengthening, of which 16 were still satisfied at a mean follow-up of four years. In addition, all articles published between 1974 and January 2015 on subcutaneous and/or submuscular transposition of the ulnar nerve for recalcitrant cubital tunnel syndrome were reviewed. We found that previously published studies on this subject are too heterogeneous to compare. No recommendation can thus be made regarding the surgical technique for persistent or recurrent cubital tunnel syndrome. Our series shows that the musculofascial lengthening technique for submuscular transposition is a good option. More research is needed to compare the different surgical treatments. Level of evidence: IV

Building a corpus of spontaneous interaction

This revised version supersedes all previous versions (e.g., Field Manual 2010)

The Effects of Cyclic Loading and Motion on the Implant–Cement Interface and Cement Mantle of PEEK and Cobalt–Chromium Femoral Total Knee Arthroplasty Implants: A Preliminary Study

This study investigated the fixation of a cemented PEEK femoral TKA component. PEEK and CoCr implants were subjected to a walking gait cycle for 10 million cycles (MC), 100,000 cycles or 0 cycles (unloaded control). A method was developed to assess the fixation at the cement–implant interface, which exposed the implants to a fluorescent penetrant dye solution. The lateral condyles of the implants were then sectioned and viewed under fluorescence to investigate bonding at the cement–implant interface and cracking of the cement mantle. When tested for 100,000 cycles, debonding of the cement–implant interface occurred in both PEEK (61%) and CoCr (13%) implants. When the duration of testing was extended (10 MC), the percentage debonding was further increased for both materials to 88% and 61% for PEEK and CoCr, respectively. The unloaded PEEK specimens were 79% debonded, which suggests that, when PEEK femoral components are cemented, complete bonding may never occur. Analysis of cracks in the cement mantle showed an absence of full-thickness cracks in the unloaded control group. For the 100,000-cycle samples, on average, 1.3 and 0.7 cracks were observed for PEEK and CoCr specimens, respectively. After 10 MC, these increased to 24 for PEEK and 19 for CoCr. This was a preliminary study with a limited number of samples investigated, but shows that, after 10 MC under a walking gait, substantial debonding was visible for both PEEK and CoCr implants at the cement–implant interface and no significant difference in the number of cement cracks was found between the two materials

Irrigation Management Strategies for Fodder Beet (\u3ci\u3eBeta vulgaris\u3c/i\u3e L.) Crops

The production of fodder beet (Beta vulgaris L.) in New Zealand is concentrated in the South Island, and often requires irrigation to achieve high yields. Development of efficient irrigation management strategies requires information on the effect of timing and rate of irrigation on crop growth. A field study was conducted on a moderately deep soil at Chertsey, Canterbury, New Zealand, to evaluate crop growth responses to five irrigation managements: Rain-fed (control), weekly replacement of full evapotranspiration (FullET-weekly), and 50% of evapotranspiration replaced weekly (HalfET-weekly), fortnightly (HalfET-2weekly) or 3-weekly (HalfET-3weekly). Irrigation to replace ET was adjusted to account for rainfall received between irrigation events. The crop was sown on 11 October 2015. Dry matter (DM) and green leaf area index (LAI) were quantified at 4-weekly intervals from 21 December 2015 until 16 May 2016. Water use efficiency (WUE) was calculated from weekly time domain reflectometry and neutron probe measurements of volumetric soil water content (to 0.8 m depth) and crop biomass. Final yield was lowest for Rain-fed (17.1 t DM/ha) and highest for FullET-weekly (28.9 t DM/ha) treatments. The remaining treatments did not differ in yield, producing 22.4±1.6 t DM/ha, but differed significantly from the Rain-fed and FullET-weekly treatments. Yield differences were associated with the rate of leaf area expansion and duration of critical LAI values (≥ 3.0 m2/m2), which were greater for FullET-weekly than for other treatments. Rain-fed and FullET-weekly treatments resulted in the highest and lowest WUE (81 versus 47 kg DM/ha/mm). The remaining treatments did not differ in WUE, averaging 67±3.6 kg DM/ha/mm. Our results show yield benefits from irrigation, with the best outcome from FullET-weekly given the soil type and weather conditions. However, under water restriction conditions, the HalfET-3weekly management is recommended over more frequent partial ET replacements because it would reduce irrigation costs without penalising yield

The relationship between mental disorders and actual and desired subjective social status

Mental disorders are associated with lower subjective social status (SSS), but a more nuanced understanding of this relationship is needed. We examined the influence of disorder age of onset and recency on SSS and studied whether mental disorders are also associated with the discrepancy between actual and desired SSS.Method Data are from the baseline and second wave of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2). Mental disorders were assessed with the Composite International Diagnostic Interview (CIDI 3.0), while both actual and desired SSS were assessed with a ten-rung ladder. Linear regression was used to examine the association between mental disorders and SSS.Results Of 5303 participants, 2237 had a lifetime mental disorder at baseline. These participants reported significantly lower actual SSS (6.28) at follow-up than healthy participants (6.66, B = -0.38 [95% CI -0.48 to -0.27], p < 0.001) and a significantly greater actual-desired SSS discrepancy (1.14 v. 1.05 after controlling for actual SSS, B = 0.09 [0.01-0.17], p = 0.024). Lower age of onset of the first mental disorder was marginally significantly associated with lower actual SSS (B = 0.006 [0.000-0.012], p = 0.046). More recent disorders were also associated with lower actual SSS (B = 0.015 [0.005-0.026], p = 0.005), such that participants whose disorder remitted a ≥6 years before baseline were statistically indistinguishable from healthy participants.Conclusions Lifetime mental disorders are associated with lower actual SSS and a slightly greater discrepancy between actual and desired SSS. However, people with mental disorders in (long-term) remission have a similar social status as healthy participants