Взаимосвязь между сахарным диабетом и раком поджелудочной железы

Experience of treating 183 pancreatic cancer patients was summarized. The frequency of carbohydrate metabolism disorder and time dependence between the onset of diabetes and pancreatic cancer detection were examined. It was found that 133 (72.7 %) patients had glucose intolerance. Diabetes mellitus was detected in 49 (26.8 %) patients and 28 of them (57.2 %) had new-onset diabetes. In the latter group of patients, it can be considered that detection of endocrine disease was an early sign of pancreatic cancer.Обобщен опыт лечения 183 больных раком поджелудочной железы. У пациентов исследовались частота нарушения углевод- ного обмена, а также временная зависимость между началом сахарного диабета и выявлением опухоли поджелудочной железы. Установлено, что у 133 (72,7 %) пациентов наблюдалось нарушение метаболизма глюкозы, сахарный диабет установлен у 49 (26,8 %), причем у 28 (57,2 %) был впервые выявленным

Russian consensus on exoand endocrine pancreatic insufficiency after surgical treatment

The Russian consensus on exo - and endocrine pancreatic insufficiency after surgical treatment was prepared on the initiative of the Russian "Pancreatic Club" on the Delphi method. His goal was to clarify and consolidate the opinions of specialists on the most relevant issues of diagnosis and treatment of exo - and endocrine insufficiency after surgical interventions on the pancreas. An interdisciplinary approach is provided by the participation of leading gastroenterologists and surgeons

Встречаемость мутаций в генах BRCA1 и BRCA2 у больных раком поджелудочной железы

BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularlyМутации в генах BRCA1 и BRCA2 могут играть роль в формировании риска рака поджелудочной железы (РПЖ), однако критерии включения пациентов в BRCA-диагностику остаются неясными. Присутствие повторяющейся мутации BRCA1 5382insC анализировалось у 150 больных РПЖ, при этом выявлено 2 носителя упомянутого аллеля. Полный анализ кодирующей области гена BRCA2 выполнен у 8 пациентов, обнаружен 1 дефектный вариант (BRCA2 5197_5198delTC). Все 3 больных с мутацией имели собственный или семейный анамнез BRCA-ассоциированных онкологических заболеваний. Таким образом, BRCA-тестирование случаев РПЖ целесообразно ограничить только теми пациентами, у которых имеются клинические признаки наследственного характера заболевани

RELATIONSHIP BETWEEN DIABETES MELLITUS AND PANCREATIC CANCER

Experience of treating 183 pancreatic cancer patients was summarized. The frequency of carbohydrate metabolism disorder and time dependence between the onset of diabetes and pancreatic cancer detection were examined. It was found that 133 (72.7 %) patients had glucose intolerance. Diabetes mellitus was detected in 49 (26.8 %) patients and 28 of them (57.2 %) had new-onset diabetes. In the latter group of patients, it can be considered that detection of endocrine disease was an early sign of pancreatic cancer

PROFESSOR VALENTINA PAVLOVNA KLESHCHEVNIKOVA (to the 100 th anniversary of the birth)

Surgery, as well as almost all sections of medicine, has always been a man’s affair. Valentina Pavlovna Kleshchevnikova (1919–2009), one of the few women who became a professor of surgery, stood out in the mid-20th century galaxy of surgeons. October 2019 marks the 100th anniversary of her birth. Having started her professional career during the Great Patriotic War in a military hospital, she gained experience and knowledge in many areas of surgery. Professor Sergey Vladimirovich Heinatz, her mentor and teacher, had extensive experience in esophageal surgery and while still working in Khabarovsk made – one of the first in the country – esophagoplasty resection with one-stage esophagoplasty. Professor V. P. Kleshchevnikova, a promising surgeon, was also involved in the development of this very difficult field of surgery. It was the material that formed the basis for the candidate’s and later doctoral dissertation of a young, but already experienced specialist. After defending her thesis, V. P. Kleshchevnikova, a young doctor of medical sciences, was elected by competition to head the Department of Hospital Surgery at Petrozavodsk State University (Petrozavodsk). For a long time almost all the leading surgeons of Petrozavodsk and the Republic of Karelia were her students or students of the Department headed by V. P. Kleshchevnikova – someone listened to her lectures, someone worked with her in the clinic or had the honor to «get» Valentina Pavlovna as a mentor or opponent for the defense of the thesis. In Saint Petersburg, at the Mariinsky Hospital, and later at Petrozavodsk State University, a prominent and very bright part of Professor Kleshchevnikova’s surgical and scientific career took place. She was a worthy representative of the pleiad of the most brilliant surgeons, and if we take female surgeons, she was probably the most outstanding surgeon

Growth of germanium quantum dots on oxidized silicon surface

Epitaxial growth of germanium quantum dots on an oxidized silicon surface is considered. A kinetic model o