Systems thinking: critical thinking skills for the 1990s and beyond

This pdf article discusses the need for teaching systems thinking and critical thinking skills. Systems thinking and systems dynamics are important for developing effective strategies to close the gap between the interdependent nature of our problems and our ability to understand them. This article calls for a clearer view of the nature of systems thinking and the education system into which it must be transferred. Educational levels: Graduate or professional

Epitope mapping using mRNA display and a unidirectional nested deletion library

In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library. After six rounds of selection, epitope-like peptides were identified that contain two to five consecutive, internal histidines and are biased for arginine residues, without any other identifiable consensus. The epitope was further refined by constructing a high-complexity, unidirectional fragment library from the final selection pool. Selection by mRNA display minimized the dominant peptide from the original selection to a 15-residue functional sequence (peptide Cmin: RHDAGDHHHHHGVRQ; K-D = 38 nM). Other peptides recovered from the fragment library selection revealed a separate consensus motif (ARRXA) C-terminal to the histidine track. Kinetics measurements made by surface plasmon resonance, using purified Fab (antigen-binding fragment) to prevent avidity effects, demonstrate that the selected peptides bind with 10- to 75-fold higher affinities than a hexahistidine peptide. The highest affinity peptides (K-D approximate to 10 nM) encode both a short histidine track and the ARRXA motif, suggesting that the motif and other flanking residues make important contacts adjacent to the core polyhistidine-binding site and can contribute > 2.5 kcal/mol of binding free energy. The fragment library construction methodology described here is applicable to the development of high-complexity protein or cDNA expression libraries for the identification of protein-protein interaction domains

Hydrogen film cooling of a small hydrogen-oxygen thrust chamber and its effect on erosion rates of various ablative materials

An experimental investigation was conducted to determine what arrangement of film-coolant-injection orifices should be used to decrease the erosion rates of small, high temperature, high pressure ablative thrust chambers without incurring a large penalty in combustion performance. All of the film cooling was supplied through holes in a ring between the outer row of injector elements and the chamber wall. The best arrangement, which had twice the number of holes as there were outer row injection elements, was also the simplest. The performance penalties, presented as a reduction in characteristic exhaust velocity efficiency, were 0.8 and 2.8 percentage points for the 10 and 20 percent cooling flows, respectively, The best film-coolant injector was then used to obtain erosion rates for 19 ablative materials. The throat erosion rate was reduced by a factor of 2.5 with a 10 percent coolant flow. Only the more expensive silica phenolic materials had low enough erosion rates to be considered for use in the nozzle throat. However, some of the cheaper materials might qualify for use in other areas of small nozzles with large throat diameters where the higher erosion rates are more acceptable

Interactions of vortices with rarefaction solitary waves in a Bose-Einstein condensate and their role in the decay of superfluid turbulence

There are several ways to create the vorticity-free solitary waves -- rarefaction pulses -- in condensates: by the process of strongly nonequilibrium condensate formation in a weakly interacting Bose gas, by creating local depletion of the condensate density by a laser beam, and by moving a small object with supercritical velocities. Perturbations created by such waves colliding with vortices are studied in the context of the Gross-Pitaevskii model. We find that the effect of the interactions consists of two competing mechanisms: the creation of vortex line as rarefaction waves acquire circulation in a vicinity of a vortex core and the loss of the vortex line to sound due to Kelvin waves that are generated on vortex lines by rarefaction pulses. When a vortex ring collides with a rarefaction wave, the ring either stabilises to a smaller ring after emitting sound through Kelvin wave radiation or the entire energy of the vortex ring is lost to sound if the radius of the ring is of the order of the healing length. We show that during the time evolution of a tangle of vortices, the interactions with rarefaction pulses provide an important dissipation mechanism enhancing the decay of superfluid turbulence.Comment: Revised paper accepted by Phys. Rev.

Working Group 5: Measurements technology and active experiments

Technology issues identified by working groups 5 are listed. (1) New instruments are needed to upgrade the ability to measure plasma properties in space. (2) Facilities should be developed for conducting a broad range of plasma experiments in space. (3) The ability to predict plasma weather within magnetospheres should be improved and a capability to modify plasma weather developed. (4) Methods of control of plasma spacecraft and spacecraft plasma interference should be upgraded. (5) The space station laboratory facilities should be designed with attention to problems of flexibility to allow for future growth. These issues are discussed

J0316+4328: a Probable "Asymmetric Double" Lens

We report a probable gravitational lens J0316+4328, one of 19 candidate asymmetric double lenses (2 images at a high flux density ratio) from CLASS. Observations with the Very Large Array (VLA), MERLIN and the Very Long Baseline Array (VLBA) imply that J0316+4328 is a lens with high confidence. It has 2 images separated by 0.40", with 6 GHz flux densities of 62 mJy and 3.2 mJy. The flux density ratio of ~19 (constant over the frequency range 6-22 GHz) is the largest for any 2 image gravitational lens. High resolution optical imaging and deeper VLBI maps should confirm the lensing interpretation and provide inputs to detailed lens models. The unique configuration will give strong constraints on the lens galaxy's mass profile.Comment: Accepted to MNRAS Letters. 5 pages, 6 figures, 3 table

ρ\rho Polarization and `Model Independent' Extraction of ∣Vub∣/∣Vcd∣|V_{ub}|/|V_{cd}| from D→ρℓνD\to\rho\ell\nu and B→ρℓνB\to\rho\ell\nu

We briefly discuss the predictions of the heavy quark effective theory for the semileptonic decays of a heavy pseudoscalar to a light one, or to a light vector meson. We point out that measurement of combinations of differential helicity decay rates at Cleo-c and the $B$ factories can provide a model independent means of extracting the ratio $|V_{ub}|/|V_{cd}|$. We briefly discuss the corrections to this prediction.Comment: 8 pages, LaTeX, 1 figur

Kinematic dynamo action in a sphere. I. Effects of differential rotation and meridional circulation on solutions with axial dipole symmetry

A sphere containing electrically conducting fluid can generate a magnetic field by dynamo action, provided the flow is sufficiently complicated and vigorous. The dynamo mechanism is thought to sustain magnetic fields in planets and stars. The kinematic dynamo problem tests steady flows for magnetic instability, but rather few dynamos have been found so far because of severe numerical difficulties. Dynamo action might, therefore, be quite unusual, at least for large-scale steady flows. We address this question by testing a two-parameter class of flows for dynamo generation of magnetic fields containing an axial dipole. The class of flows includes two completely different types of known dynamos, one dominated by differential rotation (D) and one with none. We find that 36% of the flows in seven distinct zones in parameter space act as dynamos, while the remaining 64% either fail to generate this type of magnetic field or generate fields that are too small in scale to be resolved by our numerical method. The two previously known dynamo types lie in the same zone, and it is therefore possible to change the flow continuously from one to the other without losing dynamo action. Differential rotation is found to promote large-scale axisymmetric toroidal magnetic fields, while meridional circulation (M) promotes large-scale axisymmetric poloidal fields concentrated at high latitudes near the axis. Magnetic fields resembling that of the Earth are generated by D > 0, corresponding to westward flow at the surface, and M of either sign but not zero. Very few oscillatory solutions are found

Multiplicative random walk Metropolis-Hastings on the real line

In this article we propose multiplication based random walk Metropolis Hastings (MH) algorithm on the real line. We call it the random dive MH (RDMH) algorithm. This algorithm, even if simple to apply, was not studied earlier in Markov chain Monte Carlo literature. The associated kernel is shown to have standard properties like irreducibility, aperiodicity and Harris recurrence under some mild assumptions. These ensure basic convergence (ergodicity) of the kernel. Further the kernel is shown to be geometric ergodic for a large class of target densities on $\mathbb{R}$. This class even contains realistic target densities for which random walk or Langevin MH are not geometrically ergodic. Three simulation studies are given to demonstrate the mixing property and superiority of RDMH to standard MH algorithms on real line. A share-price return data is also analyzed and the results are compared with those available in the literature

Theoretical aspects of high--Q^2 deep inelastic scattering

We present an overview of the theory of high--Q^2 deep inelastic scattering. We focus in particular on the theoretical uncertainties in the predictions for neutral and charged current cross sections obtained by extrapolating from lower Q^2.Comment: 10 (Latex) pages, including 6 embedded figures, uses epsfig.sty, ioplppt.sty and iopl12.sty; Plenary talk presented at the 3rd UK Phenomenology Workshop on HERA Physics, Durham, September 1998, to be published in the Proceeding