Real world big data for clinical research and drug development

The objective of this paper is to identify the extent to which real world data (RWD) is being utilized, or could be utilized, at scale in drug development. Through screening peer-reviewed literature, we have cited specific examples where RWD can be used for biomarker discovery or validation, gaining a new understanding of a disease or disease associations, discovering new markers for patient stratification and targeted therapies, new markers for identifying persons with a disease, and pharmacovigilance. None of the papers meeting our criteria was specifically geared toward new novel targets or indications in the biopharmaceutical sector; the majority were focused on the area of public health, often sponsored by universities, insurance providers or in combination with public health bodies such as national insurers. The field is still in an early phase of practical application, and is being harnessed broadly where it serves the most direct need in public health applications in early, rare and novel disease incidents. However, these exemplars provide a valuable contribution to insights on the use of RWD to create novel, faster and less invasive approaches to advance disease understanding and biomarker discovery. We believe that pharma needs to invest in making better use of EHRs and the need for more precompetitive collaboration to grow the scale of this 'big denominator' capability, especially given the needs of precision medicine research

LiFi Reception from Organic Photovoltaic Modules Subject to Additional DC Illuminations and Shading Effects

International audienceIn this paper, we study the performance of organic photovoltaic (OPV) modules as LiFi receivers in two specific configurations. The PV-based LiFi receiver is first exposed to an additional homogeneous light source with different intensity levels and then the influence of partial lighting is studied (shading effect). In both cases, we compare the sensibility and the cutoff frequency of LiFi transmission when the solar cell is operated either in short-circuit mode (i.e. when it is loaded with an active transimpedance amplifier) or in open circuit mode (i.e. when it is terminated with an high impedance passive load). While the OPV module performance decreases in open-circuit mode as a function of the DC illumination level, we observe an improvement of the cutoff frequency in short circuit mode. This result seems very promising for outdoor LiFi transmissions but also for indoor conditions where natural light can disturb LiFi communications. Theoretical explanations involving physical parameters for energy harvesting (carrier mobility, lumped series resistance) are proposed to justify the observed behaviors. Finally, experimental results of shaded solar cells are provided in the two operating modes (open-circuit and short-circuit). We show that sensibility and bandwidth of OPV modules strongly depend on both the shading configuration and the operating mode

LiFi Reception from Organic Photovoltaic Modules Subject to Additional DC Illuminations and Shading Effects

International audienceIn this paper, we study the performance of organic photovoltaic (OPV) modules as LiFi receivers in two specific configurations. The PV-based LiFi receiver is first exposed to an additional homogeneous light source with different intensity levels and then the influence of partial lighting is studied (shading effect). In both cases, we compare the sensibility and the cutoff frequency of LiFi transmission when the solar cell is operated either in short-circuit mode (i.e. when it is loaded with an active transimpedance amplifier) or in open circuit mode (i.e. when it is terminated with an high impedance passive load). While the OPV module performance decreases in open-circuit mode as a function of the DC illumination level, we observe an improvement of the cutoff frequency in short circuit mode. This result seems very promising for outdoor LiFi transmissions but also for indoor conditions where natural light can disturb LiFi communications. Theoretical explanations involving physical parameters for energy harvesting (carrier mobility, lumped series resistance) are proposed to justify the observed behaviors. Finally, experimental results of shaded solar cells are provided in the two operating modes (open-circuit and short-circuit). We show that sensibility and bandwidth of OPV modules strongly depend on both the shading configuration and the operating mode

Organic Photovoltaic Modules Installation: Italy and Algeria Case Studies

We here report our latest achievements regarding some installations of ASCA® by ARMOR Organic Photovoltaic Modules realized by roll to roll printing. The performances of ASCA® OPV Modules were measured in two sites, in Italy and in Algeria, and monitored over time. We found that 10-20 kWh/m2 of total irradiation are needed to reach nominal performances due to photo-stabilization behavior. Furthermore, a 1.15 kW OPV power plant was realized, vertically integrated on a building wall, and measurements data were collected for each string. Special attention is paid to compare, in terms of energy yield (kWh/kWp), the OPV Plant with a c-Si PV Plant, already present on the same site: OPV showed a gain of 12% on energy yield during the monitoring period