Changes of some blood indices and myocardial electrolyte content during hypokinesia

Using special hypokinetic cages, the volume changes of circulating blood, its hematocrit and protein content, volume ratios between extra- and intracellular liquids in the body, as well as electrolyte content in the blood and myocardium during hypokinesia were investigated experimentally in rabbits

Morphometric Analysis of Hippocampal Pyramidal Neurons in situ and in Grafts Developing in the Anterior Eye Chambers of Young and Aged Wistar Rats

We performed a morphometric analysis of the somatic and nuclear areas in the pyramidal neurons of the hippocampal fields CA1 and CA3 in situ and in grafts developing for six weeks in the anterior eye chambers of young (3-to-9 wk.) and of aged (18-to-19.5 mos.) Wistar rats. The mean areas of the CA1 pyramidal somata and nuclei were significantly decreased in the aged animals in situ. The mean parameters of the CA3 pyramidal neurons were not changed, although their distribution was different (bimodal versus unimodal in the young animals). In both groups of recipients, the areas of CA1 neurons and of their nuclei were significantly larger in the grafted tissue than those found in situ. The areas of CA3 neurons did not show any difference in aged recipients and demonstrated only slight hypertrophy in young recipients. We concluded that the area sizes of the pyramidal cell bodies and nuclei in CA1 neurons are more sensitive than those of CA3 neurons to both aging and transplantation. The age of recipients did not significantly influence the growth and development of grafted pyramidal cells

Strategies for Overcoming University Researchers’ Writer’s Block

This paper reveals the importance of overcoming writer’s block for university researchers as second language writers. The idea and materials for the paper come from the experience of the Center for Academic Writing “Impulse” at the University of Tyumen, Russia. The target audience of the Center is the university faculty and researchers who have a lack of time to immerse in the writing process, rather they mainly want to obtain an immediate tangible result. However, our research shows that they often get frustrated by their inability to complete their writing piece because they get stuck at different stages of the writing process. For example, some people find it difficult to finish their papers, or others fade away in the middle, but the main problem is to start writing. Thus, they face writer’s block which can be referred to moderate blockage. To overcome the block, we offer the researchers a variety of activities during courses and special projects. This paper describes two strategies: classroom intervention including mainly pre-writing activities, such as freewriting, looping, word association, aimed to overcome the fear of a white page, and individualized intervention based on the project entitled “Drop in & Reboot your Writing”. The project comprised 10-20 weekly individual meetings lasting for 30 minutes and aiming at dealing with a particular writing issue. The individual approach to each participant led to a better understanding of the causes of writer’s block and finding the cures. These strategies aim to develop researchers’ positive attitude to writing, to enable them to boost their awareness of the writing process in receiving the desired results, and build confidence as second language writers

Methyl 4-methyl-2-oxo-1,2,5,6-tetra­hydro-4H-pyrrolo[3,2,1-ij]quinoline-6-carboxyl­ate

In the title mol­ecule, C14H15NO3, the six-membered heterocyclic ring exhibits an envelope conformation. In the crystal, C—H⋯π inter­actions link the mol­ecules into centrosymmetric dimers, and weak inter­molecular C—H⋯O hydrogen bonds link these dimers into columns propagated along [100]

Multinuclear, heteronuclear, and heterovalent complexes in solutions

The results of investigations on the multinuclear 3d-metal compounds in solutions are generalized. The conditions for their formation, the stability, properties, composition, and interaction of the unpaired electrons of the metal centers are discussed. Interrelation between the magnetic properties, composition, and structure of the multinuclear complexes of paramagnetic ions is analyzed. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Pharmacovigilance System Master File: An Overview of Changes in the EAEU Good Pharmacovigilance Practice

The development of international regulatory practices and the accumulation of new experience in pharmacovigi­lance prompted the need to amend the Rules of Good Pharmacovigilance Practice of the Eurasian Economic Union (EAEU GVP Guideline), first adopted in 2016.The aim of the study was to review, from a regulatory expert’s perspective, the changes to the structure and presentation of the pharmacovigilance system master file (PSMF) introduced with the amendment of the EAEU GVP Guideline effective since December 6, 2022.The authors compared the requirements for the PSMF outlined in the new edition of the EAEU GVP Guideline adopted by Decision No.81 of the Council of the Eurasian Economic Commission of 19.06.2022 “On Amendments to the Rules of Good Pharmacovigilance Practice of the Eurasian Economic Union” with the requirements described in the previous version of this document.The structure and content of Module III, Pharmacovigilance System Master File, have been significantly amended in the new version of the EAEU GVP Guideline; this will require marketing authorisation holders (MAHs) to revise the PSMFs describing pharmacovigilance system data. The most significant editorial changes have been made to the paragraphs concerning the PSMF format, the pharmacovigilance quality system, and the presentation of information in the Annexes. The amendment has strengthened the control of records and documentation related to the pharmacovigilance system. Electronic PSMFs are acceptable; electronic book-marking and searchable text make working with the PSMF more convenient for representatives of MAHs and experts of regulatory authorities. Aligning of the PSMF with the requirements of the new edition of the EAEU GVP Guideline will contribute to improving the pharmacovigilance system operation and performance

Translational mobility of water molecules and Li+, F-, and Al3+ ions in aqueous solutions of LiCl, KF, and Al(NO3)3

The concentration dependences of the overall self-diffusion coefficients of water molecules, F- and Li+ ions, and [Al3+(H2O)6] hydrated ions measured in aqueous solutions of LiCl, KF, and Al(NO3)3 are discussed. An analysis of the whole set of experimental results shows that translational mobility of water molecules in solutions of electrolytes is largely determined by the degree of hydration of the ions and is virtually independent of their translational mobility; translational mobilities of the ions themselves depend on the structural characteristics of their hydration sheaths and the structure of water around them

Analysis of Noncompliances with Legislative Requirements in Pharmacovigilance Materials of Registration Dossiers

Since 1 January 2021 the authorisation of medicines in the Russian Federation has to be performed according to the Eurasian Economic Union (EAEU) procedure. The Pharmacovigilance System Master File (PSMF) is the main document describing the pharmacovigilance system of the marketing authorisation holder (MAH) or its authorised representative.  The aim of the study was to analyse noncompliances with the EAEU requirements, which were revealed during PSMF assessment.Materials and methods: the authors analysed 687 pharmacovigilance documents included in registration dossiers that were submitted for assessment from 1 January to 30 June, 2021.  Results: the authors identified and systematised the main noncompliances with the EAEU requirements in terms of presentation, content, completeness of each PSMF section. They analysed the frequency of noncompliances in PSMFs and identified the most frequent flaws of MAHs’ pharmacovigilance systems.Conclusions: the authors give recommendations for elimination of significant noncompliances identified during PSMF assessment, which may include: timely updating, maintenance, and revision of the documents in accordance with changes in legislation and any other significant changes, regular training of pharmacovigilance staff, etc. The results of this review will be useful for MAHs as the main participants of the marketing authorisation process who are directly involved in the pharmacovigilance system management at the pre- and post-authorisation stages, and will help them prevent potential mistakes when drawing up pharmacovigilance system documents

The capabilities of MRI in the lung lesions diagnosis in patients with COVID-19

Backgrounds. The imaging diagnostic methods have become particularly important during the COVID-19 pandemic, and computed tomography of the thorax (CT) is considered to be the gold standard in the cases of lung lesions and in the evaluation of changes in the pulmonary parenchyma in dynamics. However, it is well known that the CT method is associated with a significant radiation dose, especially given the fact that repeated, and often reiterated control CT-tests are required for many patients who suffer COVID-19 or have recovered from the disease. In order to reduce the potential radiation exposure and receive some additional diagnostic information, we applied the magnetic resonance imaging (MRI) method for viral pneumonia at the FRCC of FMBA of Russia, which was redesigned as a center for the treatment of patients with COVID-19. Aim. The aim is to evaluate the possibilities of the lung MRI in the diagnosis of pneumonia caused by the new coronaviral infection, to describe the specific symptoms of lung parenchyma lesions using various pulse sequences, and compare the results with the CT data. Methods. The article is based on the practice of applying high-resolution computed tomography (HRCT) and MRI of the lungs in 15 patients with pneumonia caused by COVID-19. Results. The comparison of the HRCT data and T2-weighted images (T2-WI) in 100% of cases revealed a complete correlation in the size, number and position of the lung tissue areas with reduced air saturation by the type of ground glass opacity and the consolidation zones. The level of linear and reticular changes detection in MRI reached 73.3%. Free fluid in the pleural cavities in a moderate and minimal volume was revealed on T2-WI in 12 patients (80% of cases), while it was not diagnosed by HRCT in all the cases. The mediastinal and intra-pulmonary lymph nodes were visualized distinctly. In T1-weighted images (T1-WI), the areas of ground glass opacity were either not visualized, or were represented by smaller areas when compared to the HRCV data and reticular changes were also displayed worse. In 73.3% cases, the consolidation zones on T1-WI fully corresponded or were almost similar in characteristics to changes visualized by HRCT. At the same time, it is worth noting that performing T1-WI out phase more clearly displayed the consolidation zones when compared to T1-WI in phase. Foci of increased signal on T1-WI with fat suppression were registered in 3 patients against the background of consolidation sites which in comparison with the data of T2-WI, would suggest the presence of parenchymal hemorrhages. Conclusion. Lung MRI is a fairly sensitive method for identifying areas of ground glass opacity and consolidation, reticular changes and lymphadenopathy, and is superior to HRCT when displaying pleural effusion. Chest MRI may be recommended as a diagnostic method for suspected pulmonary COVID-19 lesion in children and pregnant women in order to exclude ionizing radiation exposure, as well as for monitoring the condition of lung tissue after viral pneumonia, if the patient was previously exposed to a high radiation dose