Informetrics on accidents and trauma

MEDLINE database has been analysed for 1995-97 on index Accidents and Trauma. Publications output has been classified year-wise country-wise, journal-wise and other fine structure characteristics have been found. High frequency keywords have been identified. Other valuable data have been compiled. The value of informater for decision-making is brought out by this study and the comprehensive data compilation by MEDLINE is established

BULLOUS PEMPHIGOID A RARE AUTOIMMUNE DISEASE: A CASE REPORT

Background. Bullous pemphigoid (BP) is a rare autoimmune blistering skin disease in the elderly and it is manifested by cutaneous blisters on the skin lesions. The objective was to emphasize the rare case of BP. Methods. A case report of BP in a 58-year-old male patient admitted to a dermatology ward is presented. Results. A 58-year-old male patient with complaints of fluid-filled skin lesions, was examined initially over the trunk, gradually progressed involving B/L upper and lower extremities. Even though the patient was treated with the recommended therapy of corticosteroid (Dexamethasone) along with adjuvant drugs, new skin lesions continued to develop, and the patient’s condition worsened. The Prednisolone was started in place of Dexamethasone on the fifth day of treatment at its higher dose (50mg/day), the Prednisolone proved its efficacy to combat the extensive condition of BP. Conclusions. Bullous pemphigoid is a distressing blistering skin disease. Untreated disease is often fatal because of the susceptibility to infection and fluid-electrolyte disturbances. The mortality of patients with bullous pemphigoid has been significantly reduced with the advent of new therapies and treatment modalities. The treatment with systemic and topical corticosteroids forms the mainstay of treatment along with other adjuvant drugs. In the present case study, the use of Prednisolone has proven its efficacy in the extensive disease state of BP and improved the patient’s quality of life

Study of Prescribing Pattern, Identification of Drug Related Problems and Therapeutic Intervention in Cardio Vascular Diseases (CVD) Patients

Cardiovascular disease (CVD) is a disorder of heart and blood vessels. CVD is one of the major causes of deaths in India, which contributed around 30 to 40%. The aim of the study was to study the prescribing pattern of drugs, identification of drug related problems and therapeutic intervention in CVD patients. A hospital based prospective and observational study was carried out for a period of nine months in a south Indian tertiary care hospital. Among 120 selected patients, 79 were male  (65.83%) and 41 were female  (34.16%), more number of patients (35) were between the age group of 55-64 (29.16%) of which 27 were males & 8 were females, and very less number of patients (6) were between the age group 85-94 (5%) of which all the 6 were male. Hypertension is the most commonest and dominant disorder, which affected 47(39.16%) patients, in which 30 were male (25%) and 17 were female (14.16%). Most common risk factor is HTN followed with smoking and diabetes of 45 patients (37.5%). The most often prescribed pattern adopted in CVD is Dual therapy, it is most frequently used therapy 50 (41.66%) and quadruple therapy is less frequently 6(6.5%) used. The diuretics and calcium channel blocker combination were maximally prescribed class of drugs as a dual therapy. A total of 47 drug-drug interactions were found, among 12 were major, 15 were moderate and 20 were minor interactions. Clinical pharmacist has intervened with the help of other health care professionals in order to reduce the risk factor and minimise the drug-drug interactions. The study provides the benefits of presence of clinical pharmacist in a hospital setting, in order to prevent the medication related errors and provide the expertise pharmacotherapy opinion in CVD patients, which improves the patient compliance.  Hence study justifies a need of active collaboration between clinical pharmacist, physician and other health care professionals for the better management of CVD patients. Keywords: Prescribing Pattern; Cardio Vascular Diseases; Drug Related Problems; Therapeutic Intervention

Medical Eponyms: prolific authors and their favourite Journals

There were strong linkages between authors in the domain 'medical eponyms' and journals

Transforming Bibliographic Data Bases into Bibliographics

MEDLINE Data Base was search for Accidents and Trauma and retrived records were bibliometrically analysed

Centenary year of the discovery of radio-activity in thorium, polonium and radium

Contribution of Marie Curie has been highlighted

International Journal of Biopharmaceutics SYNTHESIS AND BIOLOGICAL EVALUATION OF THIOMORPHOLINE DERIVATIVES USED AS A POTENT BIOLOGICAL AGENTS

ABSTRACT The purpose of this research was to development of new potent bioactive molecule with less toxic, safer and easy available. Modern therapeutic is based on scientific observation supported by systematic assessment of activity of drug is simulated and clinical condition. The integrity of the drug molecule, optimization of biological effect, uniform and consistent availability of drug from the dosage. Present work deals with the preparation of thiomorpholie derivatives by nucleophilic substitution reaction. Thiomorpholine (I) and P-chlorobenzonitrile (II) on reflux gives 4-thiomorpholin4ylbenzonitrile (III) then this upon hydrolysis by using sodium hydroxide and methanol gives corresponding 4-thiomorpholin-4ylbenzoic acid (IV).This acid on treatment with thionyl chloride gives corresponding 4-thiomorpholin4ylbenzoyl chloride (V).This is treated with hydrazine hydrate gives 4-thiomorpholin-4ylbenzohydrazide (VI) then this hydrazide is treated with various substituted aromatic aldehyde and heterocyclic compound to form thiomorpholine derivatives. Hydrazide derivatives were synthesized to increase Log P value by increasing microbial intracellular concentration and to decrease microbial resistance. The newly synthesized compounds were tested for its antimicrobial, analgesic and antiinflammatory activity. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1 H NMR and mass spectral data

Development of Fluroquinolones as a potent antibacterial agents:A Review

ABSTRACT The fluoroquinolones are a series of synthetic antibacterial agents that are used in the treatment of variety of bacterial infections. These agents inhibit the DNA gyrase, abolishing its activity by interfering with the DNA-rejoining reaction.The inhibition of the resealing leads to the liberation of fragments that are subsequently destroyed by the bacterial exo-nucleases. All fluoroquinolones accumulate within bacteria very rapidly, so that a steady-state intrabacterial concentration is obtained within a few minutes. Resistance develops slowly and is usually chromosomal and not plasmid mediated. However, development of resistance and transfer between animal and human pathogens has become a fervently argued issue among the microbiologists.Another concern regarding the use of new quinolones in the veterinary field is a possible detrimental effect on the environment. It still seems unlikely that the controlled use of veterinary quinolones will give rise to unfavorable effects on the environment