24 research outputs found
Π€ΠΠΠΠΠΠΠΠΠ§ΠΠ‘ΠΠΠβΠΠ€Π€ΠΠΠ’βΠΠ ΠΠΠΠΠ’ΠΠΠβΠΠΠΠΠΠ‘Π’ΠΠΠ ΠβΠΠΠ‘ΠΠΠ ΠΠΠΠΠ’ΠΠ₯βΠΠβΠΠΠΠ ΠΠΠ£ΠΠ’ΠΠΠΠ«Π₯βΠΠΠΠΠ’ΠΠ«Π₯
The article focuses on the fact, that probiotic specimens affect insufficiently due to lack of specific microorganisms for gut colonization, response to antibiotics or some feeds, way of applying and doses and periods of applying. The authors explain the importance of estimating the effect of applying new probiotics on domestic animals. The researchers conducted experiments on cats and dogs; the experimental results show the effect of probiotic Zoovestin. The paper estimates the state of blood in the beginning of the experiment and declares that blood of cats and dogs corresponds to the standards. The authors observed the microorganisms as coccus, coliform bacillus with low enzyme ability, yeast-like fungi, globulolytic coliform bacillus and proteus in gut microflora of pets. There were no changes in blood indexes of pets observed. Zoovestin improved gut flora of cats and dogs and made its indexescorrepond to the physiological standards. The researchers observed an increase in number of bifid bacterium and coliform bacillus with low enzyme ability. The number of coccus flora and coliform bacillus with low enzyme ability was reduced and globulolytic coliform bacillus and proteus were removed. The researchers observed better appetite and exterior that characterizes their welfare.Β ΠΡΠΎΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΈΠ½ΠΎΠ³Π΄Π° Π΄Π°ΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ, ΡΡΠΎ ΡΠ²ΡΠ·ΡΠ²Π°Π΅ΡΡΡ Ρ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠΏΠΎΠ² ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π΄Π»Ρ ΠΊΠΎΠ»ΠΎΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΈΠ΄Π° ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΊ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ ΠΈΠ»ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΠΌ ΠΊΠΎΡΠΌΠ°ΠΌ, ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ, Π²ΠΊΠ»ΡΡΠ°Ρ Π΄ΠΎΠ·Ρ ΠΈ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΎΡΠΎΠ±ΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°Π΅Ρ ΠΎΡΠ΅Π½ΠΊΠ° ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². Π ΠΎΠΏΡΡΠ°Ρ
Π½Π° ΠΊΠΎΡΠΊΠ°Ρ
ΠΈ ΡΠΎΠ±Π°ΠΊΠ°Ρ
ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΠΈΡΠΈΠ΄ΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΠΉ β Π·ΠΎΠΎΠ²Π΅ΡΡΠΈΠ½Π°. ΠΡΠ΅Π½ΠΊΠ° Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π² Π½Π°ΡΠ°Π»Π΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΠΏΠΎΠΊΠ°Π·Π°Π»Π°, ΡΡΠΎ ΠΈ ΠΊΠΎΡΠΊΠΈ, ΠΈ ΡΠΎΠ±Π°ΠΊΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΊΡΠΎΠ²ΠΈ Π² Π³ΡΠ°Π½ΠΈΡΠ°Ρ
Π½ΠΎΡΠΌΡ. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π² ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΠ΅ Π±ΡΠ»ΠΈ Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ°ΠΊΠΈΠ΅ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΡ, ΠΊΠ°ΠΊ ΠΊΠΎΠΊΠΊΠΈ, ΠΊΠΈΡΠ΅ΡΠ½Π°Ρ ΠΏΠ°Π»ΠΎΡΠΊΠ° Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ, Π΄ΡΠΎΠΆΠΆΠ΅ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ Π³ΡΠΈΠ±Ρ, Π³Π΅ΠΌΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΈΡΠ΅ΡΠ½Π°Ρ ΠΏΠ°Π»ΠΎΡΠΊΠ° ΠΈ ΠΏΡΠΎΡΠ΅ΠΉ. ΠΠ΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π½Π΅ ΠΏΡΠ΅ΡΠ΅ΡΠΏΠ΅Π»ΠΈ. ΠΠΎΠΎΠ²Π΅ΡΡΠΈΠ½ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π» ΠΊΠΈΡΠ΅ΡΠ½ΡΡ ΡΠ»ΠΎΡΡ ΠΊΠΎΡΠ΅ΠΊ ΠΈ ΡΠΎΠ±Π°ΠΊ ΠΈ ΠΏΡΠΈΠ²Π΅Π» Π΅Π΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΊ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π½ΠΎΡΠΌΠ°ΠΌ. ΠΡΠΎΠΈΠ·ΠΎΡΠ»ΠΎ Π½Π΅ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π±ΠΈΡΠΈΠ΄ΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΠΉ ΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ°Π»ΠΎΡΠΊΠΈ Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ. Π‘Π½ΠΈΠ·ΠΈΠ»ΠΎΡΡ Π΄ΠΎ Π½ΠΎΡΠΌΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΡΠ»ΠΎΡΡ ΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ°Π»ΠΎΡΠΊΠΈ Ρ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ, ΡΠ»ΠΈΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π° Π³Π΅ΠΌΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΈΡΠ΅ΡΠ½Π°Ρ ΠΏΠ°Π»ΠΎΡΠΊΠ° ΠΈ ΠΏΡΠΎΡΠ΅ΠΉ. Π£Π»ΡΡΡΠΈΠ»ΡΡ Π°ΠΏΠΏΠ΅ΡΠΈΡ ΠΈ Π²Π½Π΅ΡΠ½ΠΈΠΉ Π²ΠΈΠ΄ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅Ρ ΠΈΡ
Π±Π»Π°Π³ΠΎΠΏΠΎΠ»ΡΡΠΈΠ΅
Integrative Neuropsychological Characteristics of Subcortical-Frontal Brain Regions as a Schizophrenia Liability Factor
Para estudiar las caracterΓsticas de las regiones cerebrales subcΓ³rtico-frontal, se investigaron la funciΓ³n y la evaluaciΓ³n de su relaciΓ³n con la vulnerabilidad a la esquizofrenia en 59 pacientes y 23 controles, empleando los mΓ©todos neuropsicolΓ³gicos de Luria. El anΓ‘lisis estableciΓ³ anormalidades bilaterales de la funciΓ³n de las zonas lobulares prefrontal y frontal profunda en pacientes comparados con los controles. Estas anormalidades eran mΓ‘s predominantes en el hemisferio izquierdo. Las coeficientes de correlaciΓ³n punto-biserial de algunos indicadores neuropsicolΓ³gicos integrativos con la vulnerabilidad a la esquizofrenia eran de 0,39 Β± 0,11 y 0,28 Β± 0,09, respectivamente. Los datos obtenidos llevan a la discusiΓ³n de los indicadores neuropsicolΓ³gicos integrativos de regiones subcortical-frontales del cerebro que se revelan como marcadores potenciales de vulnerabilidad a la esquizofrenia y confirma el papel de la asimetrΓa estructural y funcional del cerebro en la patogΓ©nesis de la esquizofrenia.In order to study neuropsychological characteristics of subcortical-frontal brain regions function and assessment of their relation with vulnerability to schizophrenia 59 patients and 23 controls were investigated using Luriaβs neuropsychological methods. The analysis established bilateral abnormalities of the function of prefrontal and profound frontal lobe zones in patients as compared with controls. These abnormalities were more predominate in the left hemisphere. Point biserial correlation coefficients of determined integrative neuropsychological indicators with liability to schizophrenia were 0.39 Β± 0.11 and 0.28 Β± 0.09, for the left and right brain zones respectively. The obtained data permits discussion of the integrative neuropsychological indicators of subcorticalfrontal brain regions as potential markers of liability to schizophrenia and confirms the role of structural and functional brain asymmetry in the pathogenesis of schizophrenia
ΠΠΎΠΌΠ΅ΠΎΡΡΠ°Π· ΡΠΎΠ±Π°ΠΊ ΠΏΡΠΈ ΠΈΡ ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΠΈ ΡΡΡ ΠΈΠΌ ΠΊΠΎΡΠΌΠΎΠΌ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΈ ΠΊΠΎΡΠΌΠΎΠΌ Π΄ΠΎΠΌΠ°ΡΠ½Π΅Π³ΠΎ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ
The work aimed to test a newly developed new formulation of domestic dry food for dogs. Some homeostasis indicators in dogs transferred from natural feeding to complete dry food were assessed. The studies were conducted on two groups of dogs kept by their owners in apartment conditions and on personal plots. Dogs of the 1st group (experimental) were transferred from feeding homemade food to industrially produced complete dry food. The diet of dogs in group 2 (control) did not change and still consisted of meat products, cereals and vegetables.Biomaterial for research (blood, faeces) was taken at the beginning of the experiment and after two months of controlled feeding. The bioelemental and biochemical composition of blood, haematological parameters and faecal microbiology were studied. The dogs' and general clinical conditions were assessed, including determination of live weight at the beginning and end of the two-month study. The results of the elemental analysis showed that two months after the transfer of dogs of the 1st group from the "natural" type of feeding to dry food in the blood of the animals, the concentration of arsenic, lead, strontium, chromium, iodine, selenium and zinc decreased, but the levels of lithium increased nickel and molybdenum. Of the biochemical and haematological parameters, AST, ALT, Ξ²-lipoproteins, amylase, lipase, total protein and haemoglobin increased statistically significantly, but alkaline phosphatase level decreased. In addition, switching dogs to dry food contributed to a decrease in 1 g of faeces in the concentration of E. coli with regular enzymatic activity, lactose-negative E. coli, microflora of the genus Proteus and yeast-like fungi. During the experimental period, animals of the 2nd (control) group showed an increase in the amount of microflora of the genus Protea and lactose-negative E. coli. In the intestines of dogs of both groups during the study period, an increase in coccal flora and a decrease in the number of E. coli hemolytic and E. aerogenes were observed.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ ΡΠΎΡΡΠΎΡΠ»Π° Π² ΠΈΡΠΏΡΡΠ°Π½ΠΈΠΈ Π²Π½ΠΎΠ²Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ Π½ΠΎΠ²ΠΎΠΉ ΡΠ΅ΡΠ΅ΠΏΡΡΡΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡ
ΠΎΠ³ΠΎ ΠΊΠΎΡΠΌΠ° Π΄Π»Ρ ΡΠΎΠ±Π°ΠΊ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π°Β ΠΎΡΠ΅Π½ΠΊΠ° Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π·Π° ΡΠΎΠ±Π°ΠΊ, ΠΏΠ΅ΡΠ΅Π²Π΅Π΄Π΅Π½Π½ΡΡ
Ρ Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΡ Π½Π° ΠΏΠΎΠ»Π½ΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΡΡΡ
ΠΎΠΉ ΠΊΠΎΡΠΌ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° Π΄Π²ΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΡΠΎΠ±Π°ΠΊ, ΡΠΎΠ΄Π΅ΡΠΆΠ°Π²ΡΠΈΡ
ΡΡ ΠΈΡ
Π²Π»Π°Π΄Π΅Π»ΡΡΠ°ΠΌΠΈ Π² ΠΊΠ²Π°ΡΡΠΈΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΈ Π½Π° ΠΏΡΠΈΡΡΠ°Π΄Π΅Π±Π½ΡΡ
ΡΡΠ°ΡΡΠΊΠ°Ρ
. Π‘ΠΎΠ±Π°ΠΊΠΈ 1-ΠΉ Π³ΡΡΠΏΠΏΡ (ΠΎΠΏΡΡΠ½ΠΎΠΉ) Π±ΡΠ»ΠΈ ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΠ΅ΡΠ΅Π²Π΅Π΄Π΅Π½Ρ Ρ ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΡ ΠΊΠΎΡΠΌΠΎΠΌ Π΄ΠΎΠΌΠ°ΡΠ½Π΅Π³ΠΎ ΠΏΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π½Π° ΠΏΠΎΠ»Π½ΠΎΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΡΡΡ
ΠΎΠΉ ΠΊΠΎΡΠΌ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π°. Π Π°ΡΠΈΠΎΠ½ ΡΠΎΠ±Π°ΠΊ 2-ΠΉ Π³ΡΡΠΏΠΏΡ (ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ)Β Π½Π΅ ΠΌΠ΅Π½ΡΠ»ΡΡ ΠΈ ΠΏΠΎ-ΠΏΡΠ΅ΠΆΠ½Π΅ΠΌΡ ΡΠΎΡΡΠΎΡΠ» ΠΈΠ· ΠΌΡΡΠΎΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ², ΠΊΠ°Ρ ΠΈ ΠΎΠ²ΠΎΡΠ΅ΠΉ. ΠΠΈΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Β Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ (ΠΊΡΠΎΠ²Ρ, ΡΠ΅ΠΊΠ°Π»ΠΈΠΈ) Π±ΡΠ°Π»ΠΈ Π² Π½Π°ΡΠ°Π»Π΅ ΠΎΠΏΡΡΠ° ΠΈ ΡΠΏΡΡΡΡ Π΄Π²Π° ΠΌΠ΅ΡΡΡΠ° ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΡ. ΠΠ·ΡΡΠ°Π»ΠΈ Π±ΠΈΠΎΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΡΠΉ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΎΡΡΠ°Π² ΠΊΡΠΎΠ²ΠΈ, Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡ ΠΊΠ°Π»Π°. ΠΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΊΠΎΠ½Π΄ΠΈΡΠΈΠΈ ΡΠΎΠ±Π°ΠΊ, ΠΈΡ
ΠΎΠ±ΡΠ΅Π΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΆΠΈΠ²ΠΎΠΉ ΠΌΠ°ΡΡΡ Π² Π½Π°ΡΠ°Π»Π΅ ΠΈ ΠΏΠΎ ΠΎΠΊΠΎΠ½ΡΠ°Π½ΠΈΠΈ Π΄Π²ΡΡ
ΠΌΠ΅ΡΡΡΠ½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΡΠΏΡΡΡΡ Π΄Π²Π° ΠΌΠ΅ΡΡΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄Π° ΡΠΎΠ±Π°ΠΊ 1-ΠΉ Π³ΡΡΠΏΠΏΡ Ρ Β«Π½Π°ΡΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎΒ» ΡΠΈΠΏΠ° ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΡ Π½Π° ΡΡΡ
ΠΎΠΉ ΠΊΠΎΡΠΌ Π² ΠΊΡΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΡΠ½ΠΈΠ·ΠΈΠ»Π°ΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΌΡΡΡΡΠΊΠ°, ΡΠ²ΠΈΠ½ΡΠ°, ΡΡΡΠΎΠ½ΡΠΈΡ, Ρ
ΡΠΎΠΌΠ°, ΠΉΠΎΠ΄Π°, ΡΠ΅Π»Π΅Π½Π° ΠΈ ΡΠΈΠ½ΠΊΠ°, Π½ΠΎ ΠΏΠΎΠ²ΡΡΠΈΠ»ΠΈΡΡ ΡΡΠΎΠ²Π½ΠΈ Π»ΠΈΡΠΈΡ, Π½ΠΈΠΊΠ΅Π»Ρ ΠΈ ΠΌΠΎΠ»ΠΈΠ±Π΄Π΅Π½Π°. ΠΠ· Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ Π²ΡΡΠΎΡΠ»ΠΈ AST, ALT, Ξ²-Π»ΠΈΠΏΠΎΠΏΡΠΎΡΠ΅ΠΈΠ΄Ρ, Π°ΠΌΠΈΠ»Π°Π·Π°, Π»ΠΈΠΏΠ°Π·Π°, ΠΎΠ±ΡΠΈΠΉ Π±Π΅Π»ΠΎΠΊ ΠΈ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½, Π½ΠΎ ΡΠ½ΠΈΠ·ΠΈΠ»ΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ΅Π»ΠΎΡΠ½ΠΎΠΉ ΡΠΎΡΡΠ°ΡΠ°Π·Ρ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄ ΡΠΎΠ±Π°ΠΊ Π½Π° ΡΡΡ
ΠΎΠΉ ΠΊΠΎΡΠΌ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π» ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π² 1 Π³ ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ E.coli Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ, Π»Π°ΠΊΡΠΎΠ·ΠΎΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠΉ E.coli, ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ ΡΠΎΠ΄Π° ΠΏΡΠΎΡΠ΅Ρ ΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ
Π³ΡΠΈΠ±ΠΎΠ². Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
2-ΠΉ (ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ) Π³ΡΡΠΏΠΏΡ Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ ΠΎΠΏΡΡΠ° ΠΎΡΠΌΠ΅ΡΠ΅Π½ ΡΠΎΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ ΡΠΎΠ΄Π° ΠΏΡΠΎΡΠ΅Ρ ΠΈ Π»Π°ΠΊΡΠΎΠ·ΠΎΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠΉ E.coli. Π ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ΅ ΡΠΎΠ±Π°ΠΊ ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΊΠΊΠΎΠ²ΠΎΠΉ ΡΠ»ΠΎΡΡ ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° E.coli hemolytic ΠΈ E.aerogenes.
Relationship of depressive disorders with hypertension, its control and other metabolic risk factors in the Tyumen Oblast population of men and women. Data from the study βEpidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federationβ (ESSE-RF)
Aim. To study the association between depression and metabolic cardiovascular risk factors, hypertension (HTN) and its control in a random sample of Tyumen Oblast population of men and women aged 25-64 years.Material and methods. The study object was a random sample of the population of the Tyumen and the Tyumen Oblast aged 25-64 years, examined as part of the ESSE-RF epidemiological study. The study included 1658 participants. Among them, 30,3% (n=503) were men, while 69,7% (n=1155) β women. Mean age was 48,9Β±11,4 years. The prevalence of metabolic risk factors (hyperlipidemia, carbohydrate metabolism disorder, obesity), hypertension and the likelihood of its control in men and women with different levels of depressive disorders diagnosed using the HADS scale were assessed.Results. Compared with participants without depression, persons with psychological disorders were significantly more likely to have HTN (55,5% vs 47,6%, p<0,01), elevated levels of total cholesterol (TC) (63,9% vs 54,0%, p<0,01) and low-density lipoproteins (LDL) (66,7% vs 60,3%, p<0,05), carbohydrate metabolism disorders (8,3% vs 5,2% p<0,05), obesity (49,2% vs 37,7%, p<0,01). Significantly more often hypertensive subjects without depression took antihypertensive drugs effectively (odds ratio (OR) β 1,747, 95% confidence interval (CI), 1,001-3,053) and controlled blood pressure (OR β 1,533, 95% CI, 1,05-2,36). There was no association between the use of antihypertensives and the level of depressive disorders. Among women with depression (HADS>7), dyslipidemia (65,5% vs 57,4% for TC, p<0,05; 71,0% vs 62,9% for LDL, p<0,05), carbohydrate metabolism disorders (10,1% vs 5,2%, p<0,01), obesity (53,3% vs 43,2%, p<0,01), HTN (60,6% vs 45,6%, p<0,01) were more common. Men with clinical depression were more likely to have HTN (69,0% vs 47,7%, p<0,05), with a high level of depression β hyperlipidemia (58,9% vs 46,7% for TC, p<0,05; 67,1% vs 53,9% for LDL, p<0,05). Women with elevated depression levels were less likely to take antihypertensive drugs (30% vs 49,4%, p<0,01) and control hypertension (13,8% vs 21,2%, p<0,05).Conclusion. The data obtained confirm the association of depressive disorders with metabolic risk factors and the likelihood of HTN control, which is especially significant among women
Protection of pancreatic INS-1 Ξ²-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin
Hyperglycemia is detrimental to Ξ²-cell viability, playing a major role in the progression of Ξ²-cell loss in diabetes mellitus. The permeability transition pore (PTP) is a mitochondrial channel involved in cell death. Recent evidence suggests that PTP inhibitors prevent hyperglycemia-induced cell death in human endothelial cells. In this work, we have examined the involvement of PTP opening in INS-1 cell death induced by high levels of glucose or fructose. PTP regulation was studied by measuring the calcium retention capacity in permeabilized INS-1 cells and by confocal microscopy in intact INS-1 cells. Cell death was analyzed by flow cytometry. We first reported that metformin and cyclosporin A (CsA) prevented Ca2+-induced PTP opening in permeabilized and intact INS-1 cells. We then showed that incubation of INS-1 cells in the presence of 30βmM glucose or 2.5βmM fructose induced PTP opening and led to cell death. As both metformin and CsA prevented glucose- and fructose- induced PTP opening, and hampered glucose- and fructose- induced cell death, we conclude that PTP opening is involved in high glucose- and high fructose- induced INS-1 cell death. We therefore suggest that preventing PTP opening might be a new approach to preserve Ξ²-cell viability
Transgenic Overexpression of Active Calcineurin in Ξ²-Cells Results in Decreased Ξ²-Cell Mass and Hyperglycemia
BACKGROUND:Glucose modulates beta-cell mass and function through an initial depolarization and Ca(2+) influx, which then triggers a number of growth regulating signaling pathways. One of the most important downstream effectors in Ca(2+) signaling is the calcium/Calmodulin activated serine threonine phosphatase, calcineurin. Recent evidence suggests that calcineurin/NFAT is essential for beta-cell proliferation, and that in its absence loss of beta-cells results in diabetes. We hypothesized that in contrast, activation of calcineurin might result in expansion of beta-cell mass and resistance to diabetes. METHODOLOGY/PRINCIPAL FINDINGS:To determine the role of activation of calcineurin signaling in the regulation of pancreatic beta-cell mass and proliferation, we created mice that expressed a constitutively active form of calcineurin under the insulin gene promoter (caCn(RIP)). To our surprise, these mice exhibited glucose intolerance. In vitro studies demonstrated that while the second phase of Insulin secretion is enhanced, the overall insulin secretory response was conserved. Islet morphometric studies demonstrated decreased beta-cell mass suggesting that this was a major component responsible for altered Insulin secretion and glucose intolerance in caCn(RIP) mice. The reduced beta-cell mass was accompanied by decreased proliferation and enhanced apoptosis. CONCLUSIONS:Our studies identify calcineurin as an important factor in controlling glucose homeostasis and indicate that chronic depolarization leading to increased calcineurin activity may contribute, along with other genetic and environmental factors, to beta-cell dysfunction and diabetes
Designing the architecture of the program system for the estimation and analysis of risks in agricultural integrated production systems
The article considers the stages of designing a software package for risk assessment and analysis in agro-industrial integrated production systems, including the development of a modular architecture, the logical structure of the modules included in the software package, physical structure of the software package, software algorithms, and the interface layout
Nodular mastocytosis: a case study
A case study of nodular mastocytosis is described. Tacrolimus was used to treat skin manifestations of mastocytosis