Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography

Progression of retinal degeneration in a mouse model was studied in vivo with high-resolution spectral-domain optical coherence tomography (SD-OCT). Imaging in 3D with high depth resolution (<3 mu m), SD-OCT resolved all the major layers of the retina of control C57BL/6J mice. Images of transgenic mice having a null mutation of the rhodopsin gene revealed the anatomical consequences of retinal degeneration: thinning of the outer retina, including the outer plexiform layer (OPL), outer nuclear layer (ONL), and inner and outer segments (IS/OS). We monitored the progression of retinal degeneration in rd1 mice (C3H/HeJ) by periodically imaging the same mice from the time the pups opened their eyes on P13 to P34. SD-OCT images showed that the outer retina (OPL, ONL, IS/OS) had already thinned by 73% (100 to 27 mu m) at eye opening. The retina continued to degenerate, and by P20 the outer retina was not resolvable. The thickness of entire retina decreased from 228 mu m (control) to 152 mu m on P13 and to 98 mu m by P34, a 57% reduction with the complete loss in the outer retina. In summary, we show that SD-OCT can monitor the progression of retinal degeneration in transgenic mice.X114367sciescopu

Hamiltonian lattice QCD at finite density: equation of state in the strong coupling limit

The equation of state of Hamiltonian lattice QCD at finite density is examined in the strong coupling limit by constructing a solution to the equation of motion corresponding to an effective Hamiltonian describing the ground state of the many body system. This solution exactly diagonalizes the Hamiltonian to second order in field operators for all densities and is used to evaluate the vacuum energy density from which we obtain the equation of state. We find that up to and beyond the chiral symmetry restoration density the pressure of the quark Fermi sea can be negative indicating its mechanical instability. Our result is in qualitative agreement with continuum models and should be verifiable by future lattice simulations of strongly coupled QCD at finite density.Comment: 27 pages, 6 figures. Uses ReVTeX4 and BiBTeX. Revised versio

Order from disorder in lattice QCD at high density

We investigate the properties of the ground state of strong coupling lattice QCD at finite density. Our starting point is the effective Hamiltonian for color singlet objects, which looks at lowest order as an antiferromagnet, and describes meson physics with a fixed baryon number background. We concentrate on uniform baryon number backgrounds (with the same baryon number on all sites), for which the ground state was extracted in an earlier work, and calculate the dispersion relations of the excitations. Two types of Goldstone boson emerge. The first, antiferromagnetic spin waves, obey a linear dispersion relation. The others, ferromagnetic magnons, have energies that are quadratic in their momentum. These energies emerge only when fluctuations around the large-N_c ground state are taken into account, along the lines of ``order from disorder'' in frustrated magnetic systems. Unlike other spectrum calculations in order from disorder, we employ the Euclidean path integral. For comparison, we also present a Hamiltonian calculation using a generalized Holstein-Primakoff transformation. The latter can only be constructed for a subset of the cases we consider.Comment: 24 pages, 6 figures, 1 tabl

Exchange Current Corrections to Neutrino--Nucleus Scattering

Relativistic exchange current corrections to neutrino--nucleus cross sections are presented assuming non--vanishing strange quark form factors for the constituent nucleons. For charged current processes the exchange current corrections can lower the impulse approximation results by 10\% while these corrections are found to be sensitive to both the nuclear density and the strange quark axial form factor of the nucleon for neutral current processes. Implications on the LSND experiment to determine this form factor are discussed.Comment: 11 pages, 2 figures, revtex 3.0, full postscript version of the file and figures available at http://www.nikhefk.nikhef.nl/projects/Theory/preprints/preprints.html To appear in Phys. Rev. Lett

The nature of the Lambda(1405)

We present here some results supporting the nature of the $\Lambda(1405)$ resonance as dynamically generated from the meson baryon interaction in coupled channels and resulting from the superposition of two close-by poles. We find support for this picture in the $K^- p \to \pi^0 \pi^0 \Sigma^0$ reaction, which shows a different shape than the one obtained from the $\pi ^- p \to K^0 \pi \Sigma$ reaction. We also call the attention to the $K^- p \to \gamma \pi \Sigma$ with $\pi \Sigma$ in the $\Lambda(1405)$ region, which shows a narrow peak in the calculations around 1420 MeV. We also report on recent calculations of the radiative decay of the two $\Lambda(1405)$ states and on reactions to obtain information on these decay modes. Finally, we present results for the $pp\to p K^+\Lambda(1405)$ reaction recently measured at ANKE/COSY and compare them with theoretical results.Comment: Talk given at the NSTAR2007 Workshop, Bonn September 200

The Decuplet Revisited in χ\chiPT

The paper deals with two issues. First, we explore the quantitiative importance of higher multiplets for properties of the $\Delta$ decuplet in chiral perturbation theory. In particular, it is found that the lowest order one--loop contributions from the Roper octet to the decuplet masses and magnetic moments are substantial. The relevance of these results to the chiral expansion in general is discussed. The exact values of the magnetic moments depend upon delicate cancellations involving ill--determined coupling constants. Second, we present new relations between the magnetic moments of the $\Delta$ decuplet that are independent of all couplings. They are exact at the order of the chiral expansion used in this paper.Comment: 7 pages of double column revtex, no figure

Inclusive Neutrino Scattering in C-12: Implications for nu_mu to nu_e Oscillations

We study inclusive nu_e and nu_mu cross sections in C-12 in a theory that takes into account significant nuclear renormalization of strengths. Our calculation is in excellent agreement with the measured inclusive muon capture rate and the flux-averaged nu_e cross section, but overestimates the flux-averaged nu_mu inclusive cross section. These reactions are of crucial relevance to the issue of possible nu_mu to nu_e oscillations.We also calculate the flux-averaged cross sections in C-13 and Al-27, which are found to be consistent with the available experimental result.Comment: 11 pages, Latex. Submitted to Phys. Rev.