The faintest galaxies

We investigate the nature of Ultra Faint dwarf spheroidal galaxies (UF dSphs) in a general cosmological context, simultaneously accounting for various "classical" dSphs and Milky Way (MW) properties, including their Metallicity Distribution Function (MDF). The model successfully reproduces both the observed [Fe/H]-Luminosity relation and the mean MDF of UFs. According to our results UFs are the living fossils of H2-cooling minihaloes formed at z>8.5, i.e. before the end of reionization. They are the oldest and the most dark matter-dominated (M/L > 100) dSphs in the MW system, with a total mass of M = 10^(7-8) Msun. The model allows to interpret the different shape of UFs and classical dSphs MDF, along with the frequency of extremely metal-poor stars in these objects. We discuss the "missing satellites problem" by comparing the UF star formation efficiencies with those derived for minihaloes in the Via Lactea simulation.Comment: To appear in the conference proceeding: "First Stars and Galaxies: Challenges in the Next Decade" . Publisher: American Institute of Physics. Editors: V. Bromm, D. Whalen, N. Yoshid

Ultrastructure of cytoplasmic fragments in human cleavage stage embryos

Purpose: The goal of this study was to evaluate the ultrastructure of cytoplasmic fragments along with the effect of cytoplasmic fragment and perivitelline space coarse granulation removal (cosmetic microsurgery) from embryos before embryo transfer on ART outcomes. Methods: One hundred and fifty intracytoplasmic sperm injection cycles with male factor infertility were included in this prospective study. Patients were divided into three groups of case (n = 50), sham (n = 50), and control (n = 50). Embryos with 10–50 % fragmentation were included in this study. Cosmetic microsurgery and zona assisted hatching were only performed in case and sham groups respectively. Extracted fragments were evaluated ultrastructurally by transmission electron microscopy (TEM). Rates of clinical pregnancy, live birth, miscarriage, multiple pregnancies, and congenital anomaly in the three groups were also compared. Results: Micrographs from TEM showed that mitochondria were the most abundant structures found in the fragments along with mitochondria-vesicle complexes, Golgi apparatus, primary lysosomes, and vacuoles. There were no significant differences in demographic characteristics, laboratory and clinical data, or embryo morphological features between the groups. The rate of clinical pregnancy in control, sham, and case groups had no significant differences (24, 18, and 18 %, respectively). The rates of live birth, miscarriage, multiple pregnancy, and congenital anomaly were also similar between the different groups. Conclusions: Our data demonstrated that cosmetic microsurgery on preimplantation embryos had no beneficial effect on ART outcomes in unselected groups of patients. As mitochondria are the most abundant organelles found in cytoplasmic fragments, fragment removal should be performed with more caution in embryos with moderate fragmentation

Signals of CP Violation Beyond the MSSM in Higgs and Flavor Physics

We study an extension of the Higgs sector of the Minimal Supersymmetric Standard Model (MSSM), considering the effects of new degrees of freedom at the TeV scale, and allowing for sources of CP violation beyond the MSSM (BMSSM). We analyze the impact of the BMSSM sources of CP violation on the Higgs collider phenomenology and on low energy flavor and CP violating observables. We identify distinct Higgs collider signatures that cannot be realized, either in the case without CP violating phases or in the CP violating MSSM, and investigate the prospects to probe them at the Tevatron and the LHC. The most striking benchmark scenario has three neutral Higgs bosons that all decay dominantly into W boson pairs and that are well within the reach of the 7 TeV LHC run. On the other hand, we also present scenarios with three Higgs bosons that have masses M_Hi > 150 GeV and decay dominantly into b bbar. Such scenarios are much more challenging to probe and can even lie completely outside the reach of the 7 TeV LHC run. We explore complementary scenarios with standard MSSM Higgs signals that allow to accommodate a sizable B_s mixing phase as indicated by D0, as well as the excess in B_s --> mu+ mu- candidates recently reported by CDF. We find that, in contrast to the MSSM, a minimal flavor violating soft sector is sufficient to generate significant corrections to CP violating observables in meson mixing, compatible with EDM constraints. In particular, a sizable B_s mixing phase, S_psiphi < 0.4, can be achieved for specific regions of parameter space. Such a large B_s mixing phase would unambiguously imply a sizable suppression of S_psiKs with respect to the SM prediction and a BR(B_s --> mu+ mu-) close to the 95% C.L. upper bound reported by CDF.Comment: 58 pages, 15 figures, 2 tables, v2 matches published versio

Stochastic backgrounds of gravitational waves from extragalactic sources

Astrophysical sources emit gravitational waves in a large variety of processes occurred since the beginning of star and galaxy formation. These waves permeate our high redshift Universe, and form a background which is the result of the superposition of different components, each associated to a specific astrophysical process. Each component has different spectral properties and features that it is important to investigate in view of a possible, future detection. In this contribution, we will review recent theoretical predictions for backgrounds produced by extragalactic sources and discuss their detectability with current and future gravitational wave observatories.Comment: 10 pages, 9 figures, proceedings of the GWDAW 10 Conference, submitted to Class. & Quantum Gra

Product Lines for Service Oriented Applications - PL for SOA

Comment: In Proceedings WWV 2011, arXiv:1108.208

Perturbative approach to the structure of rapidly rotating neutron stars

We construct models of rotating stars using the perturbative approach introduced by J. Hartle in 1967, and a set of equations of state proposed to model hadronic interactions in the inner core of neutron stars. We integrate the equations of stellar structure to third order in the angular velocity and show, comparing our results to those obtained with fully non linear codes, to what extent third order corrections are needed to accurately reproduce the moment of inertia of a star which rotates at rates comparable to that of the fastest isolated pulsars.Comment: 17 pages, 5 figures, minor changes to match version accepted by Phys. Rev.

From time-series to complex networks: Application to the cerebrovascular flow patterns in atrial fibrillation

A network-based approach is presented to investigate the cerebrovascular flow patterns during atrial fibrillation (AF) with respect to normal sinus rhythm (NSR). AF, the most common cardiac arrhythmia with faster and irregular beating, has been recently and independently associated with the increased risk of dementia. However, the underlying hemodynamic mechanisms relating the two pathologies remain mainly undetermined so far; thus the contribution of modeling and refined statistical tools is valuable. Pressure and flow rate temporal series in NSR and AF are here evaluated along representative cerebral sites (from carotid arteries to capillary brain circulation), exploiting reliable artificially built signals recently obtained from an in silico approach. The complex network analysis evidences, in a synthetic and original way, a dramatic signal variation towards the distal/capillary cerebral regions during AF, which has no counterpart in NSR conditions. At the large artery level, networks obtained from both AF and NSR hemodynamic signals exhibit elongated and chained features, which are typical of pseudo-periodic series. These aspects are almost completely lost towards the microcirculation during AF, where the networks are topologically more circular and present random-like characteristics. As a consequence, all the physiological phenomena at microcerebral level ruled by periodicity - such as regular perfusion, mean pressure per beat, and average nutrient supply at cellular level - can be strongly compromised, since the AF hemodynamic signals assume irregular behaviour and random-like features. Through a powerful approach which is complementary to the classical statistical tools, the present findings further strengthen the potential link between AF hemodynamic and cognitive decline.Comment: 12 pages, 10 figure