17,781 research outputs found
Space station stabilization and control study Final engineering report
Simulation of stabilization and control for spinning, manned space station to provide artificial gravity station environmen
Temperature-dependent errors in nuclear lattice simulations
We study the temperature dependence of discretization errors in nuclear
lattice simulations. We find that for systems with strong attractive
interactions the predominant error arises from the breaking of Galilean
invariance. We propose a local "well-tempered" lattice action which eliminates
much of this error. The well-tempered action can be readily implemented in
lattice simulations for nuclear systems as well as cold atomic Fermi systems.Comment: 33 pages, 17 figure
Mn L edge resonant x-ray scattering in manganites: Influence of the magnetic state
We present an analysis of the dependence of the resonant orbital order and
magnetic scattering spectra on the spin configuration. We consider an arbitrary
spin direction with respect to the local crystal field axis, thus lowering
significantly the local symmetry. To evaluate the atomic scattering in this
case, we generalized the Hannon-Trammel formula and implemented it inside the
framework of atomic multiplet calculations in a crystal field. For an
illustration, we calculate the magnetic and orbital scattering in the CE phase
of \lsmo in the cases when the spins are aligned with the crystal lattice
vector (or equivalently ) and when they are rotated in the
-plane by 45 with respect to this axis. Magnetic spectra differ
for the two cases. For the orbital scattering, we show that for the former
configuration there is a non negligible ()
scattering component, which vanishes in the 45 case, while the () components are similar in the two cases. From the
consideration of two 90 spin canted structures, we conclude there is a
significant dependence of the orbital scattering spectra on the spin
arrangement. Recent experiments detected a sudden decrease of the orbital
scattering intensity upon increasing the temperature above the N\' eel
temperature in \lsmo. We discuss this behavior considering the effect of
different types of misorientations of the spins on the orbital scattering
spectrum.Comment: 8 figures. In the revised version, we added a note, a reference, and
a few minor changes in Figure 1 and the text. Accepted in Physical Review
Extremely low long‐term erosion rates around the Gamburtsev Mountains in interior East Antarctica
The high elevation and rugged relief (>3 km) of the Gamburtsev Subglacial Mountains (GSM) have long been considered enigmatic. Orogenesis normally occurs near plate boundaries, not cratonic interiors, and large‐scale tectonic activity last occurred in East Antarctica during the Pan‐African (480–600 Ma). We sampled detrital apatite from Eocene sands in Prydz Bay at the terminus of the Lambert Graben, which drained a large pre‐glacial basin including the northern Gamburtsev Mountains. Apatite fission‐track and (U‐Th)/He cooling ages constrain bedrock erosion rates throughout the catchment. We double‐dated apatites to resolve individual cooling histories. Erosion was very slow, averaging 0.01–0.02 km/Myr for >250 Myr, supporting the preservation of high elevation in interior East Antarctica since at least the cessation of Permian rifting. Long‐term topographic preservation lends credence to postulated high‐elevation mountain ice caps in East Antarctica since at least the Cretaceous and to the idea that cold‐based glaciation can preserve tectonically inactive topography
Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort
Background:
Protease inhibitors (PI) including boceprevir, telaprevir and simeprevir have revolutionised HCV genotype 1 treatment since their introduction. A number of pre-treatment resistance associated amino acid variants (RAVs) and polymorphisms have been associated with reduced response to treatment.
Objectives:
We measured the prevalence of RAVs/polymorphisms in a PI treatment-naïve HCV genotype 1 Scottish cohort using Sanger sequencing.
Study design:
Chronically infected, treatment-naïve, HCV genotype 1 patients (n = 146) attending NHS Greater Glasgow and Clyde clinics were investigated for RAVs/polymorphisms to the PIs boceprevir, telaprevir and simeprevir. The NS3/4A region was amplified by nested polymerase chain reaction. The 1.4 kb amplified product was sequenced using an ABI 3710XL DNA sequencer. Sequence analysis was performed using web-based ReCall (beta 2.10). Amino acid positions 36, 41, 43, 54, 55, 80, 109, 122, 155, 156, 168 and 170 were analysed for RAVs/polymorphisms.
Results:
Overall, 23.29% (34/146) of patients had an RAV or polymorphism detected. Overall, 13.69% (20/146) of patients had HCV virus that contained the Q8 K polymorphism. Other RAVs detected were: V36 M 0.70% (1/146), V36L 0.70% (1/146), T54S 6.85% (10/146), V55A 3.42% (5/146) and V/I170A 0.68% (1/146). Four patients had dual combinations of mutations (T54S + V36L; T54S + V55A and 2 patients with T54S + Q80K).
Conclusions:
Q80K was the most prevalent baseline polymorphism detected in the Scottish cohort. Simeprevir treatment is not recommended in patients infected with the Q80K genotype 1a variant. This highlights the need for baseline sequencing prior to administration of this drug in this population
The 2004 Sumatra tsunami as recorded on the Atlantic coast of South America
The 2004 Sumatra tsunami propagated throughout the World Ocean and was clearly recorded by tide gauges on the Atlantic coast of South America. A total of 17 tsunami records were found and subsequently examined for this region. Tsunami wave heights and arrival times are generally consistent with numerical modeling results. Maximum wave heights of more than 1.2 m were observed on the coasts of Uruguay and southeastern Brazil. Marked differences in tsunami height from pairs of closely located tide gauge sites on the coast of Argentina illustrate the importance that local topographic resonance effects can have on the observed wave response. Findings reveal that, outside the Indian Ocean, the highest waves were recorded in the South Atlantic and not in the Pacific as has been previously suggested
Rapid Evidence Review of Community Engagement and Resources in the UK during the COVID-19 Pandemic: How Can Community Assets Redress Health Inequities?
Community engagement, such as participating in arts, nature or leisurely activities, is positively associated with psychological and physiological wellbeing. Community-based engagement during the COVID-19 pandemic facilitated informal and local mutual aid between individuals. This rapid evidence review assesses the emergence of community-based arts, nature, music, theatre and other types of cultural engagement amongst UK communities in response to the COVID-19 pandemic. Here, we focus on all community engagement with a sub-focus on provisions accessed by and targeted towards vulnerable groups. Two hundred and fifty-six resources were included that had been created between February 2020 and January 2021. Resources were identified through Google Scholar, PubMed, Web of Science, MedRXic, PsycharXiv and searches for grey literature and items in the public domain. The majority reported services that had been adapted to become online, telephone-based or delivered at a distance from doorsteps. Several quality assessment frameworks were used to evaluate the quality of data. Whilst a number of peer-reviewed, grey literature and public domain articles were identified, less than half of the identified literature met quality thresholds. The pace of the response to the pandemic may have meant that robust evaluation procedures were not always in place
ROSAT HRI observations of Centaurus A
We present results from a sensitive high-resolution X-ray observation of the
nearby active galaxy Centaurus A (NGC 5128) with the ROSAT HRI. The 65~ksec
X-ray image clearly distinguishes different components of the X-ray emission
from Cen A: the nucleus and the jet, the diffuse galaxy halo, and a number of
individual sources associated with the galaxy. The luminosity of the nucleus
increased by a factor of two compared to an earlier ROSAT observation in 1990.
The high spatial resolution of the ROSAT HRI shows that most of the knots in
the jet are extended both along and perpendicular to the jet axis. We report
the detection of a new X-ray feature, at the opposite side of the X-ray jet
which is probably due to compression of hot interstellar gas by the expanding
southwestern inner radio lobe.Comment: To be published in Astrophys. Journal Letters. 4 pages, 3 plate
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