60 research outputs found
Muon `Depth -- Intensity' Relation Measured by LVD Underground Experiment and Cosmic-Ray Muon Spectrum at Sea Level
We present the analysis of the muon events with all muon multiplicities
collected during 21804 hours of operation of the first LVD tower. The measured
angular distribution of muon intensity has been converted to the `depth --
vertical intensity' relation in the depth range from 3 to 12 km w.e.. The
analysis of this relation allowed to derive the power index, , of the
primary all-nucleon spectrum: . The `depth -- vertical
intensity' relation has been converted to standard rock and the comparison with
the data of other experiments has been done. We present also the derived
vertical muon spectrum at sea level.Comment: 7 pages, 3 figures, to be published on Phys. Rev.
Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ Π²ΡΠ·ΠΊΠΎΡΠΏΡΡΠ³ΠΈΡ ΡΠ²ΠΎΠΉΡΡΠ² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ ΠΈΠ·Π΄Π΅Π»ΠΈΠΉ Π³ΠΈΠ°Π»ΡΡΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π΄Π»Ρ Π²Π½ΡΡΡΠΈΡΡΡΡΠ°Π²Π½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ
Osteoarthritis (OA) is the most common joint disease that affects more than 80% of people over 55 years and in its final stages leads to disability. One of the safe non-surgical methods of OA treatment is intra-articular injections of hyaluronic acid (HA).Objective: to compare the viscoelastic rheological properties of HA medical products with different concentrations of sodium hyaluronate (SH) available in the Russian Federation.Material and methods. The study was carried out using a modular rheometer MCR 302 (Anton Paar, Austria). All measurements were carried out at a temperature of 25.0Β±0.1 Β°C using the measuring system "cone-plane" (angle β 2 Λ , cone diameter β 40 mm, gap height β 0.169 mm). The determination of the elastic moduli (Gβ) and viscosity (Gβ) was carried out depending on the frequency in the linear region of the shear stress, and the dynamic viscosity was determined at a shear rate of 1 sec-1.Results. The evaluation of the rheological properties of the studied samples revealed a positive relationship with the concentration of SH and no relationship with the molecular weight of SH. The highest viscoelastic properties were possessed by medical products in the 1% SH group: Armaviscon and Ripart; in the group with SH concentration of 1.5β1.6%, all the studied samples, except for Hyalubrix, showed similar higher results compared to the previous group; in the group with SH concentration of 2β3%, Armaviscon Platinum had the highest results and Flexotron Ultra and Armaviscon Forte β somewhat lower results.Conclusion. The study of the rheological viscoelastic properties of HA medical products is the most accessible method, on the basis of which it is possible to predict the clinical effect.ΠΡΡΠ΅ΠΎΠ°ΡΡΡΠΈΡ (ΠΠ) β Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ ΡΡΡΡΠ°Π²ΠΎΠ², ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ°Π΅Ρ Π±ΠΎΠ»Π΅Π΅ 80% Π»ΠΈΡ ΡΡΠ°ΡΡΠ΅ 55 Π»Π΅Ρ ΠΈ Π½Π° ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΡΡ
ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΈΠ½Π²Π°Π»ΠΈΠ΄Π½ΠΎΡΡΠΈ. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΡΡ
Π½Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π½ΡΡΡΠΈΡΡΡΡΠ°Π²Π½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΈΠ·Π΄Π΅Π»ΠΈΠΉ Π³ΠΈΠ°Π»ΡΡΠΎΠ½ΠΎΠ²ΠΎΠΈ ΠΊΠΈΡΠ»ΠΎΡΡ (ΠΠ»Π).Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ Π²ΡΠ·ΠΊΠΎΡΠΏΡΡΠ³ΠΈΡ
ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΈΠ·Π΄Π΅Π»ΠΈΠΉ ΠΠ»Π Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ Π³ΠΈΠ°Π»ΡΡΠΎΠ½Π°ΡΠ° Π½Π°ΡΡΠΈΡ (ΠΠ), Π΄ΠΎΡΡΡΠΏΠ½ΡΡ
Π΄Π»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠΎΠ΄ΡΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΎΠΌΠ΅ΡΡΠ° MCR 302 (Anton Paar, ΠΠ²ΡΡΡΠΈΡ). ΠΡΠ΅ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈΡΡ ΠΏΡΠΈ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ΅ 25,0Β±0,1 Β°Π‘ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠ·ΠΌΠ΅ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Β«ΠΊΠΎΠ½ΡΡ-ΠΏΠ»ΠΎΡΠΊΠΎΡΡΡΒ» (ΡΠ³ΠΎΠ» β 2Β°, Π΄ΠΈΠ°ΠΌΠ΅ΡΡ ΠΊΠΎΠ½ΡΡΠ° β 40 ΠΌΠΌ, Π²ΡΡΠΎΡΠ° Π·Π°Π·ΠΎΡΠ° β 0,169 ΠΌΠΌ). ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΡΠΏΡΡΠ³ΠΎΡΡΠΈ (Gβ) ΠΈ Π²ΡΠ·ΠΊΠΎΡΡΠΈ (Gβ) ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠ°ΡΡΠΎΡΡ Π² Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ ΡΠ΄Π²ΠΈΠ³Π°, Π° Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΡΠ·ΠΊΠΎΡΡΠΈ β ΠΏΡΠΈ ΡΠΊΠΎΡΠΎΡΡΠΈ ΡΠ΄Π²ΠΈΠ³Π° 1 Ρ-1.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΡΠ΅Π½ΠΊΠ° ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² Π²ΡΡΠ²ΠΈΠ»Π° ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ²ΡΠ·Ρ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΠ ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΠΎΠΉ ΠΠ. Π‘Π°ΠΌΡΠΌΠΈ Π²ΡΡΠΎΠΊΠΈΠΌΠΈ Π²ΡΠ·ΠΊΠΎΡΠΏΡΡΠ³ΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΠΎΠ±Π»Π°Π΄Π°Π»ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠ΅ ΠΈΠ·Π΄Π΅Π»ΠΈΡ Π² Π³ΡΡΠΏΠΏΠ΅ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΠ 1%: ΠΡΠΌΠ°Π²ΠΈΡΠΊΠΎΠ½ ΠΈ Π ΠΈΠΏΠ°ΡΡ; Π² Π³ΡΡΠΏΠΏΠ΅ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΠ 1,5β1,6% Π²ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠ΅ ΠΎΠ±ΡΠ°Π·ΡΡ, ΠΊΡΠΎΠΌΠ΅ Π₯ΠΈΠ°Π»ΡΠ±ΡΠΈΠΊΡΠ°, ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΡΡ
ΠΎΠΆΠΈΠ΅, Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΡΠ΅Π΄ΡΠ΄ΡΡΠ΅ΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ; Π² Π³ΡΡΠΏΠΏΠ΅ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΠ 2β3% Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΈΠΌΠ΅Π» ΠΡΠΌΠ°Π²ΠΈΡΠΊΠΎΠ½ ΠΠ»Π°ΡΠΈΠ½ΡΠΌ ΠΈ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΎ ΠΌΠ΅Π½ΡΡΠΈΠ΅ β Π€Π»Π΅ΠΊΡΠΎΡΡΠΎΠ½ Π£Π»ΡΡΡΠ° ΠΈ ΠΡΠΌΠ°Π²ΠΈΡΠΊΠΎΠ½ Π€ΠΎΡΡΠ΅.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΡΠ·ΠΊΠΎΡΠΏΡΡΠ³ΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΈΠ·Π΄Π΅Π»ΠΈΠΉ ΠΠ»Π ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π΄ΠΎΡΡΡΠΏΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ, Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ
ΠΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ°: ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ
Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and a personalized approach to therapy. At the same time, despite a wide range of therapeutic options, many patients with asthma cannot achieve control over the disease.Methodology. The target audience of these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, and functional diagnostics doctors. Each thesis-recommendation about diagnostic and therapeutic procedures has been scored according to the scales of classes of recommendations from 1 to 5 and A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to the theses, algorithms for the diagnosis and treatment of bronchial asthma, and reference materials.Conclusion. The presented clinical guidelines cover current information about the etiology and pathogenesis, classification, clinical manifestations, diagnosis, treatment, and prevention of bronchial asthma. These guidelines were approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021.Β ΠΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½Π°Ρ Π°ΡΡΠΌΠ° (ΠΠ) ΡΠ²Π»ΡΠ΅ΡΡΡ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΡΡΠ΅Π±ΡΠ΅ΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅Π½ΠΎΡΠΈΠΏΠΎΠ² ΠΈ ΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΊ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΠΈΡΠΎΠΊΠΈΠΉ Π²ΡΠ±ΠΎΡ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ, Ρ ΠΌΠ½ΠΎΠ³ΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π½Π΅ ΡΠ΄Π°Π΅ΡΡΡ Π΄ΠΎΡΡΠΈΡΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π½Π°Π΄ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ.ΠΠ΅ΡΠΎΠ΄Ρ. Π¦Π΅Π»Π΅Π²ΠΎΠΉ Π°ΡΠ΄ΠΈΡΠΎΡΠΈΠ΅ΠΉ Π΄Π°Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΡΠ²Π»ΡΡΡΡΡ Π²ΡΠ°ΡΠΈ ΠΎΠ±ΡΠ΅ΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ, ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΡ, ΠΏΠ΅Π΄ΠΈΠ°ΡΡΡ, Π°Π»Π»Π΅ΡΠ³ΠΎΠ»ΠΎΠ³ΠΈ-ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈ, ΠΏΡΠ»ΡΠΌΠΎΠ½ΠΎΠ»ΠΎΠ³ΠΈ ΠΈ Π²ΡΠ°ΡΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ. ΠΠ°ΠΆΠ΄ΡΠΉ ΡΠ΅Π·ΠΈΡ-ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡ ΠΏΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π΅ΡΠ΅Π±Π½ΡΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΠΎ ΡΠΊΠ°Π»Π°ΠΌ ΡΡΠΎΠ²Π½Π΅ΠΉ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΡΡΠΈ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ² ΠΎΡ 1 Π΄ΠΎ 5 ΠΈ ΡΠΊΠ°Π»Π΅ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠ±Π΅Π΄ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΏΠΎ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΡΠΌ Π, Π, Π‘. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ ΡΠ°ΠΊΠΆΠ΅ ΠΊΠΎΠΌΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΈ ΡΠ°Π·ΡΡΡΠ½Π΅Π½ΠΈΡ ΠΊ ΡΠΊΠ°Π·Π°Π½Π½ΡΠΌ ΡΠ΅Π·ΠΈΡΠ°ΠΌ-ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌ, Π°Π»Π³ΠΎΡΠΈΡΠΌΡ ΠΏΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠ, ΡΠΏΡΠ°Π²ΠΎΡΠ½ΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ ΠΎΡΠ²Π΅ΡΠ°ΡΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎΠ± ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅, ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΡ
, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅, Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΈ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΠ. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΎΠ΄ΠΎΠ±ΡΠ΅Π½Ρ ΠΠ°ΡΡΠ½ΠΎ-ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΌ Π‘ΠΎΠ²Π΅ΡΠΎΠΌ ΠΠΈΠ½ΠΈΡΡΠ΅ΡΡΡΠ²Π° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ (2021).
The inhibition of human platelet aggregation by a low-molecular weight chitosan
Chitosan derivatives were obtained by chemical (MW of 6 kDa, DD 99% - Ch6/99; MW13 kDa, DD 98% - Ch13/98) and enzymatic (MW of 5 kDa, DD 85% - Ch5/85; MW of 10 kDa, DD 85% - Ch10/85) depolymeri-sation of chitosan with a MW of 334 and 1000 kDa. Chitosan derivatives (almost identical MW pairs and different DD) possessed insignificant an-ticoagulant activity, did not promote human platelet aggregation and re-duced ADP or collagen-induced platelet aggregation. The studied sam-ples at a concentration of 2 mg/ml reduced the aggregation of platelets more than twice induced in 2x10-6M and 1x10-5M concentrations; at weak activation in 2x10-6M, the Ch10/85 sample was the most effective. The Ch6/99 and Ch13/98 samples were 20 times more effective at the inhibi-tion of collagen-induced platelet aggregation than the Ch10/85 sample. The latter can be explained by the greater value of positive charge (DD) and polydispersity (Mw/Mn) of chitosan samples obtained by chemical de-polymerisatio
MOBILE H EALTH TECHNOLOGY: ORGANIZATIONAL, MEDICAL AND PHARMACOEPIDEMIOLOGICAL APPROACHES FOR CSD PREVENTION IN PRE-PRIMARY CARE
Objective: to evaluate the innovative organizational, medical and pharmacoepidemiological approaches for the prevention of circulatory system diseases in pre-primary care using mobile health technologies.Materials and methods: 3,694 people went through preventive consultation (questionnaires, anthropometry, body fat and blood pressure evaluation, electrocardiography, glucose and blood cholesterol) at equipped medical sites in shopping centers and rural health posts.Results. Among the surveyed, there were both healthy people and patients cardiovascular diseases and diabetes mellitus. Behavioral (insufficient consumption of fruits and vegetables, adding more salt without trying food, physical inactivity, smoking and alcohol abuse) and nutritional (obesity, hypertension, hypercholesterolemia and glycaemia) risk factors of chronic noncommunicable diseases were detected that contribute to high mortality from circulatory system diseases in the Tver region. This is associated with low adherence to drug therapy and its lack of efficacy in patients with hypertension, ischemic heart disease and cerebrovascular diseases.Conclusion: to assess the effectiveness of CSD prevention in pre-primary care, it is possible to use mobile medical sites in shopping centers and rural health posts
Thromboresistant silicon plates modified with chitosan and heparin by the layer-by-layer assembly method
Fifteen samples of silicone plates (PlateSi, area=12 cm2), with surfaces modified layer-by-layer with chitosan and unfractionated heparin, were obtained. The sample surfaces were pre-treated by cold oxygen plasma in a planar-type plasma chemical reactor with 50 W power before coating with layered polysaccharides. Pre-treatment was carried out in two alternative operation modes of the reactor, namely in the plasma etching mode and in the reactive-ion etching mode. Thromboresistance was assessed in vitro in contact with human blood. The thromboresistant silicon plates, modified layer-by-layer (3, 5, 7, and 9 bilayers) with chitosan, with molecular weights of 65 kDa, increased with the increase in the number of layers, up to 5. An increase in the duration of thromboresistance was observed in layer-by-layer modification of the surface of the plates with chitosan with a molecular weight of 200 kDa or with quaternized chitosan with a molecular weight of 200 kDa. Some samples of highly thromboresistant, modified PlateSi contributed to the adhesion of platelets and the haemolysis of red blood cells to a lesser extent than untreated silicon plates. The three most promising samples of modified PlateSi were selected
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