A lithospheric cross-section through the Swiss Alps—II. Constraints on the mechanical structure of a continent-continent collision zone

The calculation of strength profiles along the European Geotraverse (EGT) through the Swiss Alps yields constraints on the large-scale vertical and lateral mechanical structure through the Alpine continent-continent collision zone. Strength profiles are evaluated for different assumptions on petrological stratification and strain rate and are based on temperature-depth profiles derived from transient thermo-kinematic modelling of the Neoalpine orogeny. The main contribution to the total strength results from the mantle lithosphere, which is strongly controlled by temperature. In contrast, the crustal contribution is mainly determined by variations in petrological stratification. A direct correlation between surface heat flow and the total strength of the crust, the mantle lithosphere and the entire lithosphere (crust and mantle lithosphere) is not observed. Our results demonstrate that in tectonically active areas a transient thermal model, along with detailed knowledge of the deep structure and petrology, is necessary to evaluate lithospheric strength envelopes. Inside the collision zone, strain rate has a strong control on the bottom of the mechanically strong crust, whereas outside the collision zone the effect is less significant. The cut-off depth of seismicity along the profile, which correlates largely with the bottom of the mechanically strong crust, deviates from the 300-400°C isotherm. The inferred effective elastic thickness for the Molasse Basin north of the Alps is in agreement with flexural modelling results, whereas for the Southern Alps the predictions deviat

A lithospheric cross-section through the Swiss Alps—I. Thermokinematic modelling of the Neoalpine orogeny

In this paper we develop a forward 2-D thermokinematic model to investigate the Neoalpine 35-0 Ma phase of orogeny along the European Geotraverse (EGT) through the Swiss Alps on a crustal and lithospheric scale. Using a divergence-free kinematic model (div v=0), we define mass displacements, which subsequently serve as input to a transient thermal model. the thermal model uses critically assessed material prorameters and accounts for the depth dependence of the thermal properties in processes such as crustal thickening and mantle-lithospheric subduction. Based on the presentday density pattern of the deep seismic image and estimated exhumation and shortening rates, we derive, in a first modelling step, a mass-displacement field describing the Neoalpine orogeny as a uniform process in time. In a second—thermal—modelling step, this kinematic scenario is further refined by modelling the non-uniform cooling histories of the southern Lepontine in the Penninic domain. For that purpose we adopt lithospheric shortening rates—and consequently exhumation rates—to agree with total Neoalpine shortening, while keeping the geometry of the kinematic model fixed. the resultant thermokinematic model reflects the main characteristics of Neoalpine tectonics, and shows a good overall agreement with combined geological and geophysical data. the asymmetric feature of the present-day tectonic structure along the profile is strongly reflected in the thermal structure of the lithosphere. This demonstrates the need for a kinematic model to investigate the deep-temperature field in active tectonic provinces. For further refinement of the model, the amounts of shortening have to be more precisely estimated, and a higher spatial density in geochronological and metamorphic data is required. Furthermore, surface heat-flow values are, up to now, too uncertain to constrain the predicted surface heat flow. In summary, our results show that we need, in particular, data constraining the horizontal component of the tectonic and thermal evolution. the results of the Neoalpine orogeny modelling demonstrate that the presented thermokinematic procedure yields a good first-order approximation to investigate crustal-scale and lithospheric processes. We conclude. therefore, that the approach presented provides the potential for application not only to continent-continent collision zones, but also to any active tectonic provinc

Magnetostimulated Chandges of Microhardness in Potassium Acid Phthalate Crystals

A decrease in microhardness along the (010) cleavage in potassium acid phthalate single crystals by 15--18% after the application of a permanent magnetic field was revealed for the first time. It is shown that the effect revealed is of the volume character. The role of interlayer water in the processes stimulated by a magnetic field is studied., Interlayer water plays does not cause the observed changes it only plays the part of an indicator of these changes in potassium acid phthalate crystals in a magnetic field. It is established that microhardness in the (100) plane of the crystal in an applied a magnetic field first increases by 12--15% and then remains constant in time within the accuracy of the experiment. The possibility of varying the crystal structure of potassium acid phthalate crystals by applying magnetic fields inducing rearrangement in the system of hydrogen bonds or in the defect structure is discussed.Comment: 6 pages, 7 figure

Upper Crustal Structure from the Santa Monica Mountains to the Sierra Nevada, Southern California: Tomographic Results from the Los Angeles Regional Seismic Experiment, Phase II (LARSE II)

In 1999, the U.S. Geological Survey and the Southern California Earthquake Center (SCEC) collected refraction and low-fold reflection data along a 150-km-long corridor extending from the Santa Monica Mountains northward to the Sierra Nevada. This profile was part of the second phase of the Los Angeles Region Seismic Experiment (LARSE II). Chief imaging targets included sedimentary basins beneath the San Fernando and Santa Clarita Valleys and the deep structure of major faults along the transect, including causative faults for the 1971 M 6.7 San Fernando and 1994 M 6.7 Northridge earthquakes, the San Gabriel Fault, and the San Andreas Fault. Tomographic modeling of first arrivals using the methods of Hole (1992) and Lutter et al. (1999) produces velocity models that are similar to each other and are well resolved to depths of 5-7.5 km. These models, together with oil-test well data and independent forward modeling of LARSE II refraction data, suggest that regions of relatively low velocity and high velocity gradient in the San Fernando Valley and the northern Santa Clarita Valley (north of the San Gabriel Fault) correspond to Cenozoic sedimentary basin fill and reach maximum depths along the profile of ∼4.3 km and >3 km, respectively. The Antelope Valley, within the western Mojave Desert, is also underlain by low-velocity, high-gradient sedimentary fill to an interpreted maximum depth of ∼2.4 km. Below depths of ∼2 km, velocities of basement rocks in the Santa Monica Mountains and the central Transverse Ranges vary between 5.5 and 6.0 km/sec, but in the Mojave Desert, basement rocks vary in velocity between 5.25 and 6.25 km/sec. The San Andreas Fault separates differing velocity structures of the central Transverse Ranges and Mojave Desert. A weak low-velocity zone is centered approximately on the north-dipping aftershock zone of the 1971 San Fernando earthquake and possibly along the deep projection of the San Gabriel Fault. Modeling of gravity data, using densities inferred from the velocity model, indicates that different velocity-density relationships hold for both sedimentary and basement rocks as one crosses the San Andreas Fault. The LARSE II velocity model can now be used to improve the SCEC Community Velocity Model, which is used to calculate seismic amplitudes for large scenario earthquakes

A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration

Background: Liver Regeneration is clinically of major importance in the setting of liver injury, resection or transplantation. We have demonstrated that the NF-$\kappa$B inhibitory protein A20 significantly improves recovery of liver function and mass following extended liver resection (LR) in mice. In this study, we explored the Systems Biology modulated by A20 following extended LR in mice. Methodology and Principal Findings: We performed transcriptional profiling using Affymetrix-Mouse 430.2 arrays on liver mRNA retrieved from recombinant adenovirus A20 (rAd.A20) and rAd.$\beta$galactosidase treated livers, before and 24 hours after 78% LR. A20 overexpression impacted 1595 genes that were enriched for biological processes related to inflammatory and immune responses, cellular proliferation, energy production, oxidoreductase activity, and lipid and fatty acid metabolism. These pathways were modulated by A20 in a manner that favored decreased inflammation, heightened proliferation, and optimized metabolic control and energy production. Promoter analysis identified several transcriptional factors that implemented the effects of A20, including NF-$\kappa$B, CEBPA, OCT-1, OCT-4 and EGR1. Interactive scale-free network analysis captured the key genes that delivered the specific functions of A20. Most of these genes were affected at basal level and after resection. We validated a number of A20's target genes by real-time PCR, including p21, the mitochondrial solute carriers SLC25a10 and SLC25a13, and the fatty acid metabolism regulator, peroxisome proliferator activated receptor alpha. This resulted in greater energy production in A20-expressing livers following LR, as demonstrated by increased enzymatic activity of cytochrome c oxidase, or mitochondrial complex IV. Conclusion: This Systems Biology-based analysis unravels novel mechanisms supporting the pro-regenerative function of A20 in the liver, by optimizing energy production through improved lipid/fatty acid metabolism, and down-regulated inflammation. These findings support pursuit of A20-based therapies to improve patients' outcomes in the context of extreme liver injury and extensive LR for tumor treatment or donation

Human cytomegalovirus immediate-early 1 protein rewires upstream STAT3 to downstream STAT1 signaling switching an IL6-type to an IFNγ-like response

MN and CP were supported by the Wellcome Trust (www.wellcome.ac.uk) Institutional Strategic Support Fund and CP was supported by the Deutsche Forschungsgemeinschaft (PA 815/2-1; www.dfg.de).The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced to express IE1 exhibit global repression of IL6- and oncostatin M-responsive STAT3 target genes. This repression is followed by STAT1 phosphorylation and activation of STAT1 target genes normally induced by IFNγ. The observed repression and subsequent activation are both mediated through the same region (amino acids 410 to 445) in the C-terminal domain of IE1, and this region serves as a binding site for STAT3. Depletion of STAT3 phenocopies the STAT1-dependent IFNγ-like response to IE1. In contrast, depletion of the IL6 receptor (IL6ST) or the STAT kinase JAK1 prevents this response. Accordingly, treatment with IL6 leads to prolonged STAT1 instead of STAT3 activation in wild-type IE1 expressing cells, but not in cells expressing a mutant protein (IE1dl410-420) deficient for STAT3 binding. A very similar STAT1-directed response to IL6 is also present in cells infected with a wild-type or revertant hCMV, but not an IE1dl410-420 mutant virus, and this response results in restricted viral replication. We conclude that IE1 is sufficient and necessary to rewire upstream IL6-type to downstream IFNγ-like signaling, two pathways linked to opposing actions, resulting in repressed STAT3- and activated STAT1-responsive genes. These findings relate transcriptional repressor and activator functions of IE1 and suggest unexpected outcomes relevant to viral pathogenesis in response to cytokines or growth factors that signal through the IL6ST-JAK1-STAT3 axis in hCMV-infected cells. Our results also reveal that IE1, a protein considered to be a key activator of the hCMV productive cycle, has an unanticipated role in tempering viral replication.Publisher PDFPeer reviewe

Géodynamique andine : résumés étendus = Andean geodynamics : extended abstracts

Les nouvelles données géologiques et géophysiques indiquent que l'arc et l'arrière-arc du sud de la Bolivie résultent de deux mécanismes d'épaississement. Le premier (27-5 Ma) est du chevauchement par cisaillement simple crustal, avec épaississement de la croûte inférieure par cisaillement pur. Cette phase rend compte du raccourcissement entre l'Altiplano et la zone interandine, ainsi que de l'épaississement et du soulèvement dans l'Altiplano et la Cordillère occidentale. La deuxième phase (0-5 Ma) est de type subduction continentale et entraîne un raccourcissement dans la zone sub-andine, avec épaississement et soulèvement dans la Cordillère orientale. Ce concept est étudié par un modèle de coupes équilibrées. (Résumé d'auteur

A lithospheric cross section through the Swiss Alps - II. Constraints on the mechanical structure of a continent-continent collision zone

ISSN:1365-246XISSN:0956-540