2,021 research outputs found
Radiative capture of polarized neutrons by polarized protons
A model-independent irreducible tensor approach to p(n,gamma)d is presented
and an explicit form for the spin-structure of the matrix for the reaction is
obtained in terms of the Pauli spin-matrices for the neutron and the proton.
Expressing the multipole amplitudes in terms of the triplet --> triplet and
singlet --> triplet transitions, we point out how the initial singlet and
triplet contributions to the differential cross section can be determined
empirically.Comment: Revised version; typeset using RevTeX4; 6 pages, no figure
The Wolf-Rayet binaries of the nitrogen sequence in the Large Magellanic Cloud: spectroscopy, orbital analysis, formation, and evolution
Massive Wolf-Rayet (WR) stars dominate the radiative and mechanical energy
budget of galaxies and probe a critical phase in the evolution of massive stars
prior to core-collapse. It is not known whether core He-burning WR stars
(classical WR, cWR) form predominantly through wind-stripping (w-WR) or binary
stripping (b-WR). With spectroscopy of WR binaries so-far largely avoided due
to its complexity, our study focuses on the 44 WR binaries / binary candidates
of the Large Magellanic Cloud (LMC, metallicity Z~0.5 Zsun), identified on the
basis of radial velocity variations, composite spectra, or high X-ray
luminosities. Relying on a diverse spectroscopic database, we aim to derive the
physical and orbital parameters of our targets, confronting evolution models of
evolved massive stars at sub-solar metallicity, and constraining the impact of
binary interaction in forming them. Spectroscopy is performed using the Potsdam
Wolf-Rayet (PoWR) code and cross-correlation techniques. Disentanglement is
performed using the code Spectangular or the shift-and-add algorithm.
Evolutionary status is interpreted using the Binary Population and Spectral
Synthesis (BPASS) code, exploring binary interaction and chemically-homogeneous
evolution.
No obvious dichotomy in the locations of apparently-single and binary WN
stars on the Hertzsprung-Russell diagram is apparent. According to commonly
used stellar evolution models (BPASS, Geneva), most apparently-single WN stars
could not have formed as single stars, implying that they were stripped by an
undetected companion. Otherwise, it must follow that pre-WR mass-loss/mixing
(e.g., during the red supergiant phase) are strongly underestimated in standard
stellar evolution models.Comment: accepted to A&A on 10.05.2019; 69 pages (25 main paper + 44
appendix); Corrigendum: Shenar et al. 2020, A&A, 641, 2: An unfortunate typo
in the implementation of the "transformed radius" caused errors of up to
~0.5dex in the derived mass-loss rates. This has now been correcte
Unfolding of eigenvalue surfaces near a diabolic point due to a complex perturbation
The paper presents a new theory of unfolding of eigenvalue surfaces of real
symmetric and Hermitian matrices due to an arbitrary complex perturbation near
a diabolic point. General asymptotic formulae describing deformations of a
conical surface for different kinds of perturbing matrices are derived. As a
physical application, singularities of the surfaces of refractive indices in
crystal optics are studied.Comment: 23 pages, 7 figure
On Albanese torsors and the elementary obstruction
We show that the elementary obstruction to the existence of 0-cycles of
degree 1 on an arbitrary variety X (over an arbitrary field) can be expressed
in terms of the Albanese 1-motives associated with dense open subsets of X.
Arithmetic applications are given
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Gene association study of the Urokinase Plasminogen Activator and its Receptor gene in Alzheimerâs Disease
Background: The role of the innate immune system has long been associated with Alzheimerâs disease (AD). There is now accumulating evidence that the soluble Urokinase Plasminogen Activator Receptor pathway, and its genes, PLAU and PLAUR may be important in AD, and yet there have been few genetic association studies to explore this.
Objectives: This study utilises the DNA bank of the Brains for Dementia Research cohort to investigate the genetic association of common polymorphisms across the PLAU and PLAUR genes with AD.
Methods: TaqMan genotyping assays were used with standard procedures followed by association analysis in PLINK.
Results: No association was observed between the PLAU gene and AD, however two SNPs located in the PLAUR gene were indicative of a trend towards association but did not surpass multiple testing significance thresholds.
Conclusions: Further genotyping studies and exploration of the consequences of these SNPs on gene expression and alternative splicing are warranted to fully uncover the role this system may have in AD
Computational approaches to understanding protein aggregation in neurodegeneration
The generation of toxic non-native protein conformers has emerged as a unifying thread among disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Atomic-level detail regarding dynamical changes that facilitate protein aggregation, as well as the structural features of large-scale ordered aggregates and soluble non-native oligomers, would contribute significantly to current understanding of these complex phenomena and offer potential strategies for inhibiting formation of cytotoxic species. However, experimental limitations often preclude the acquisition of high-resolution structural and mechanistic information for aggregating systems. Computational methods, particularly those combine both all-atom and coarse-grained simulations to cover a wide range of time and length scales, have thus emerged as crucial tools for investigating protein aggregation. Here we review the current state of computational methodology for the study of protein self-assembly, with a focus on the application of these methods toward understanding of protein aggregates in human neurodegenerative disorders
Effect of strain on surface diffusion in semiconductor heteroepitaxy
We present a first-principles analysis of the strain renormalization of the
cation diffusivity on the GaAs(001) surface. For the example of
In/GaAs(001)-c(4x4) it is shown that the binding of In is increased when the
substrate lattice is expanded. The diffusion barrier \Delta E(e) has a
non-monotonic strain dependence with a maximum at compressive strain values (e
0) studied.
We discuss the consequences of spatial variations of both the binding energy
and the diffusion barrier of an adatom caused by the strain field around a
heteroepitaxial island. For a simplified geometry, we evaluate the speed of
growth of two coherently strained islands on the GaAs(001) surface and identify
a growth regime where island sizes tend to equalize during growth due to the
strain dependence of surface diffusion.Comment: 10 pages, 8 figures, LaTeX2e, to appear in Phys. Rev. B (2001). Other
related publications can be found at
http://www.rz-berlin.mpg.de/th/paper.htm
Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full phenotypic picture. Defining these cells at the single-cell, transcriptomic level could reveal myeloid heterogeneity in the progression and regression of kidney disease. Methods Integrated dropletâ and plate-based single-cell RNA sequencing were used in the murine, reversible, unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single-cell level during renal injury and the resolution of fibrosis. Paired blood exchange tracked the fate of monocytes recruited to the injured kidney. Results A single-cell atlas of the kidney generated using transcriptomics revealed marked changes in the proportion and gene expression of renal cell types during injury and repair. Conventional flow cytometry markers would not have identified the 12 myeloid cell subsets. Monocytes recruited to the kidney early after injury rapidly adopt a proinflammatory, profibrotic phenotype that expresses Arg1, before transitioning to become Ccr21 macrophages that accumulate in late injury. Conversely, a novel Mmp121 macrophage subset acts during repair. Conclusions Complementary technologies identified novel myeloid subtypes, based on transcriptomics in single cells, that represent therapeutic targets to inhibit progression or promote regression of kidney disease
Protein Microarray On-Demand: A Novel Protein Microarray System
We describe a novel, simple and low-cost protein microarray strategy wherein the microarrays are generated by printing expression ready plasmid DNAs onto slides that can be converted into protein arrays on-demand. The printed expression plasmids serve dual purposes as they not only direct the synthesis of the protein of interest; they also serve to capture the newly synthesized proteins through a high affinity DNA-protein interaction. To accomplish this we have exploited the high-affinity binding (âŒ3â7Ă10 â13 M) of E. coli Tus protein to Ter, a 20 bp DNA sequence involved in the regulation of E. coli DNA replication. In our system, each protein of interest is synthesized as a Tus fusion protein and each expression construct directing the protein synthesis contains embedded Ter DNA sequence. The embedded Ter sequence functions as a capture reagent for the newly synthesized Tus fusion protein. This âall DNAâ microarray can be converted to a protein microarray on-demand without need for any additional capture reagent.
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