Non-poissonian Distribution of Point Mutations in DNA

In general, for chemical reactions occurring in systems, where fluctuations are not negligibly small, it is necessary to introduce a master equation for distribution of probability of fluctuations. It has been established that the monomolecular reactions of a type as A ↔ X are described by the master equation, which leads to a Poisson distribution with the variance equal to the average value N0. However, the consideration of the Löwdin mechanism as autocatalytic non-linear chemical reactions such as A + X ↔ 2X and the corresponding master equation lead to a non-Poissonian probability distribution of fluctuations. In the presented work, first-order autocatalysis has been applied to the Löwdin's mechanism of spontaneous mutations in DNA. Describing double proton transfers between complimentary nucleotide bases along the chain by first-order autocatalytic reactions, the corresponding master equation for protons in tautomeric states becomes non-linear, and at non-equilibrium conditions this leads to the non-Poissonian distribution of spontaneous mutations in DNA. It is also suggested that the accumulation of large fluctuations of successive cooperative concerted protons along the chain may produce higher non-linearities which could have a significant impact on some biochemical processes, occurring in DNA. © Copyright © 2020 Turaeva and Oksengendler

Description of Methods of Conservative Treatment of Osteoarthritis of the Knee Joint

Osteoarthritis (OA) is a chronic progressive degenerative joint disease characterized by degradation of articular cartilage, in which subchondral changes in the bone and the development of facet osteophytes are observed. These changes lead to degradation of the articular taiga and its other components (synovial fundus, bones).Radiological signs of the disease are observed in people over 65 years of age and in more than 80% of people over 75 years of age.Osteoarthritis of the knee joint is a common disease among the common diseases of degenerative-dystrophic joint diseases leading to orthopedics. Recently, there has been a tendency to increase gonarthrosis in the armpits of young animals working on leiocatlicism

The Use of Platelet Autoplasm in the Treatment of Osteoarthritis and Its Clinical Effectiveness

Proposed injection treatment osteoarthroses based Plasmolifting method stimulate the regeneration of tissues with the use of autoplasma containing blood platelets. Methods of treatment with the use of platelet autoplasma in the treatment of osteoarthrosis of this technology is easy to use, does not require sophisticated equipment can take the pain, improve joint mobility, to promote processes of restoration of cartilage, bone and soft tissue of the joint, to prolong the period of remission of the disease

Application of Plate Autoplasma in Treatment of Osteoarthrosis and Its Clinical Effectiveness

Proposed injection treatment osteoarthroses based Plasmolifting method stimulate the regeneration of tissues with the use of autoplasma containing blood platelets. Methods of treatment with the use of platelet autoplasma in the treatment of osteoarthrosis of this technology is easy to use, does not require sophisticated equipment can take the pain, improve joint mobility, to promote processes of restoration of cartilage, bone and soft tissue of the joint, to prolong the period of remission of the disease

Synergetics in multiple exciton generation effect in quantum dots

We present detailed analysis of the non-Poissonian population of excitons produced by MEG effect in quantum dots on the base of statistic theory of MEG and synergetic approach for chemical reactions. From the analysis we can conclude that a non-Poissonian distribution of exciton population is evidence of non-linear and non-equilibrium character of the process of multiple generation of excitons in quantum dots at a single photon absorptio

On the Concept of “Complexity” in Radiation Physics

Abstract: The concept of “complexity” is considered in relation to radiation processes in condensed matter. It is shown that a combination of such properties as nanoscale, fractality, low dimension, chirality, and hierarchy in combination with high nonequilibrium create conditions for the manifestation of unusual “emergent” radiation effects (radiation synergetics, great dose reduction of threshold radiation effects, etc.). Examples of radiation effects in living and inanimate systems, interpreted within the framework of the concept of “complexity”, are presented. An overview of both previously obtained and new results is presented. © 2022, Pleiades Publishing, Ltd.Russian Foundation for Basic Research, РФФИ: 21-12-00392This work was supported by the Russian Foundation for Basic Research, project no. 21-12-00392

The Features of Auger Destruction in Quasi-One-Dimensional Objects of Inorganic and Organic Nature

Within the framework of the concept of complexity, a three-stage model of Auger destruction of inorganic and organic polymers, including the RNA of SARS-CoV-2 virus, was constructed. The possibility of selective choice of the initial K-ionization, as well as the way of realizing a giant decrease in the threshold dose of inactivation/destruction due to combined nonlinearity caused by local deformation (bending and chirality) and elemental composition around the atom - the Auger cascade pattern, has been shown. The arguments for the manifestation of this mechanism of Auger destruction as the reason for the experimentally discovered effect of suppression of serious COVID pneumonia are presented. The analogies of the manifestation of Auger destruction in objects of animate and inanimate nature are discussed. © 2021 Elsevier B.V.We are grateful to Professors Rubin A.B. Riznichenko G.Yu. Nechiporenko Yu.D. Dr. Doroshkevich A.S. (all Russia), Professors Lyubchik A. (Portugal), Matrasulov D. Dr. Maksimov S.E. (all Uzbekistan) for numerous and valuable discussions and also Prof. Ashurov Kh.B. Dr. Kurbanov M.Sh. Dr. Parpiev O. (all Uzbekistan) for the support of this direction of research, which has been developing as our own initiative