Reconstruction of the historical and cultural landscape of the late XIX century"Settlement "Kamennaya melnitsa""in the process of future designers training

Today, the problem of preservation of historical and cultural landscapes as the objects of local history, eyewitnesses to the memory of Kazan development, as the objects for thedevelopment of domestic tourism in Tatarstan, is especially urgent. One of such objects is the lost cultural and historical landscape of the studied object “Settlement“ Kamennaya Melnitsa””, located at Vysokogorsk district of the Republic of Tatarstan. At the turn of the XVIII-XIX centuries, there was the flour production, belonging to the family of merchants - the Suslovs. In the course of the work, geological, hydrological, ecological and historical features of the Blue Lakes area and the history of flour milling industry, using water mills, were studied. The article presents the main provisions, which allow to implement the project of reconstruction the historical and cultural landscape of the “Settlement “Kamennaya Melnitsa””, located within the specially protected natural area of the "Blue Lakes" reserve, into the study programs of the additional education institutions of the small homeland history. This is done with the aim to preserve historical connection of generations, as well as to promote the process of reviviscence of cultural and historical objects. Detailed characteristics and description of the objects of historical and cultural landscape is given in the work. The practical experience is shown in a logical sequence from the initial studies of the surviving remnants of historical objects to the project of its renovation and 3-D visualization.Keywords: historical and cultural landscape, cultural and historical heritage, renovation, reconstruction, 3-D visualization

Reaction of acetylacetone with diethylphosphorous acid

The reaction of equimolar amounts of acetylacetone and diethylphosphorous acid at room temperature in the presence of sodium alcoholate gives the diethyl ester of 1-methyl-1-hydroxy-3-ketobutylphosphonic acid. When heated or when treated with water-removing agents the latter cleaves water with the formation of the diethyl ester of 1-methyl-3-keto-1-buten-1-yl-phosphonicacid. The reaction of two moles of diethyl-phosphorous acid with one mole of acetylacetone under the same conditions gave 2-oxo-2-ethoxy-3,5-dimethyl-3-hydroxy-5-diethoxyphosphono-1-oxa-2-phospholane. © 1972 Consultants Bureau

Reaction of monothiobenzil with trimethyl phosphite and dimethyl phenylphosphonite

1. The reaction of monothiobenzil with trimethyl phosphite and dimethyl phenylphosphonite gave the 2,2,2-trimethoxy-4,5-diphenyl- and 2,2-dimethoxy-2,4,5-triphenyl-1,3,2-oxathiaphospholenes, which are the first members of the monocyclic 1,3,2-oxathiaphospholenes. 2. The hydrolysis of the obtained phosphoranes results in the cleavage of both the P-O and the P-S bond, with a predominant cleavage of the latter. © 1976 Plenum Publishing Corporation

Processing of mature copper tailings from concentration plant using a composite reagent

The research presents the results of laboratory studies on the flotation processing of mature copper tailings using KF2 composite reagent. KF2 flotation agent is a mixture of sodium butyl xanthate, thionocarbamate, and composite aerofloat at a ratio of 1:1:3. In the base regime, a rough copper concentrate obtained had a copper content of 10,9 % with a recovery of 74,91 %. The use of KF2 composite flotation reagent increases the extraction of copper into rough copper concentrate by 5,31 %. This made it possible to obtain a rough copper concentrate with a copper content of 13,0 % and a recovery of 80,22 %. Consumption of KF2 flotation reagent is halved compared to the basic sodium butyl xanthate collector

Processing of mature copper tailings from concentration plant using a composite reagent

The research presents the results of laboratory studies on the flotation processing of mature copper tailings using KF2 composite reagent. KF2 flotation agent is a mixture of sodium butyl xanthate, thionocarbamate, and composite aerofloat at a ratio of 1:1:3. In the base regime, a rough copper concentrate obtained had a copper content of 10,9 % with a recovery of 74,91 %. The use of KF2 composite flotation reagent increases the extraction of copper into rough copper concentrate by 5,31 %. This made it possible to obtain a rough copper concentrate with a copper content of 13,0 % and a recovery of 80,22 %. Consumption of KF2 flotation reagent is halved compared to the basic sodium butyl xanthate collector

Weighted Sobolev spaces of radially symmetric functions

We prove dilation invariant inequalities involving radial functions, poliharmonic operators and weights that are powers of the distance from the origin. Then we discuss the existence of extremals and in some cases we compute the best constants.Comment: 38 page

Structure and properties of reaction products of benzylidenebenzoylacetone with trimethyl phosphite and dimethylphosphorous acid

1. Trimethyl phosphite reacts with benzylidenebenzoylacetone to give the 1:1 adduct, which contains a pentacoordinated phosphorus atom. 2. In solution the obtained 1,2-oxaphospholene represents a mixture of two isomers, while in the solid state it has the structure of 2,2,2-trimethoxy-3,5-diphenyl-4-acetyl-1,2-oxa-4-phospholene. 3. The spectral and some of the chemical properties of the obtained phosphorane were studied. 4. Dimethylphosphorous acid adds to benzylidenebenzoylacetone to give the dimethyl ester of 1-phenyl-2-acetyl-2-benzoylethylphosphonic acid. Its keto-enol tautomerism was studied employing UV spectroscopy. © 1975 Plenum Publishing Corporation

The question of differential diagnosis of anemia in diabetes mellitus

BACKGROUND: High prevalence of anemia in diabetes mellitus (DM) determines the relevance of studying its pathogenetic aspects, the role of anemia in DM complications development and the issue of differential diagnosis between iron deficiency anemia (IDA) and anemia of chronic disease (ACD)).AIM: To establish the diagnostic value of classical parameters for diagnosing anemia in DM and propose an optimized algorithm for the differential diagnosis of ACD and IDA in DM type 1 and 2 using new markers.MATERIALS AND METHODS: The observational, single-centre, comparative, controlled, single-stage study. Patients underwent assessment of glycated hemoglobin, creatinine, microalbuminuria; indicators of iron metabolism — hematocrit, the number of erythrocytes, reticulocytes, hemoglobin, serum iron, transferrin, ferritin, the level of soluble transferrin receptors (sTfR), sTfR/logFerpitin index, and inflammation markers — erythrocyte sedimentation rate (ESR), leukocyte count, high sensitive CRP and TNF-α. ROC-analysis was used to assess the differential diagnosis markers informative content.RESULTS: We examined 135 patients: 51 with DM 1 and 84 with DM 2. The patients were stratified into groups based on anemia type: 1) ACD 2) IDA 3) latent iron deficiency 4) without ferrokinetics disorders. According to the ROC-analysis in DM patients, the following parameters had high information content in ACD. ESR — sensitivity 92%, specificity 85%, diagnostic threshold 26.5 mm/h (area under the curve (AUC) 0.943; p<0.0001); leukocyte count — sensitivity 69%, specificity 64%, diagnostic threshold 7.50x109/l (AUC 0.727; p=0.007), microalbuminuria — sensitivity 71%, specificity 72%, diagnostic threshold 29.5 mg/l (AUC 0.744; p=0.003). In DM sTfR and the sTfR /logFerritin index had high information content in IDA at diagnostic thresholds different from those for general population. The sensitivity of sTfR 71%, the specificity 71%, diagnostic threshold 1.42 ng/mL (2.9 ng/mL for general population) (AUC 0.765; p=0.024). The sensitivity of sTfR/logFerritin index 100%, the specificity 97%, diagnostic threshold 1.48 (2.0 for general population) (AUC 0.983; p=0.024).CONCLUSION: In differential diagnosis of IDA and ACD in DM, ESR, leukocyte count, microalbuminuria, sTfR and sTfR/logFerritin index have a high diagnostic value. This allows proposing them as additional markers for differential diagnosis of anemia in DM

МЕТОДЫ РАСЧЕТА QALY КАК ИНТЕГРАЛЬНОГО ПОКАЗАТЕЛЯ ЭФФЕКТИВНОСТИ В ПРОЦЕССЕ КОМПЛЕКСНОЙ ОЦЕНКИ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ

This report addresses the ways of calculating QALY (Quality-adjusted life-year). OutsideRussia, a standardized methodology to calculate QALY is in use; such an approach makes it possible to apply this universal criterion of effectiveness to the evaluation of new health technologies. Its versatility enables better decision-making on financing the medical treatment within a limited budget. With this algorithm, the financial resources are allocated in such a way as to maximize the levels of QALY. InRussiato date, the use of QALY as a measure of drug effectiveness is not yet possible because of the lack of standardized calculating methods, as well as the absence of uniform tariffs for assessing the medical status of the patient in terms of health utility. Here, we present a number of methods for estimating the health utility, which are used to calculate the QALY, and describe advantages and disadvantages of these methods. В статье описаны основные подходы к вычислению QALY. В зарубежных странах разработана и используется стандартизованная методика расчета QALY, позволяющая применять данный показатель как универсальный критерий эффективности при проведении оценки технологий здравоохранения. Его универсальность позволяет принимать решения о финансировании медицинских технологий для лечения различных заболеваний в рамках ограниченного бюджета. При этом финансовые ресурсы распределяются таким образом, чтобы максимизировать прирост QALY. В России на сегодняшний день использование QALY как критерия эффективности при проведении комплексной оценки лекарственных препаратов не представляется возможным ввиду отсутствия стандартизованной методики расчета, а также отсутствия единых тарифов для перевода профилей состояний здоровья в полезность. Приведены основные методы расчета полезностей состояний здоровья, необходимых для вычисления QALY, описаны основные достоинства и недостатки существующих методов.