Liquid Scintillator Time Projection Chamber Concept

Results are presented from a small-scale experiment to investigate the use of room temperature organic liquid scintillators as the active medium for a time projection chamber (TPC). The optical properties of liquid scintillators have long been known, but their ability to transport charge has remained, until now, largely untested. The idea of using room temperature liquids as an active medium for an ionisation chamber was first presented in \cite{EnglerTMS}. Since then the range of liquid scintillators available has been greatly developed. We present successful transport of ionization charges in a selection of both, pure organic liquid solvents and liquid scintillator cocktails over 20$\,$mm using a variety of electric drift field strengths. The target of this research is to offer a cost effective alternative to liquid noble gas detectors in neutrino physics.Comment: 6 pages, 5 figures, submitted to Proceedings 12th Pisa Meeting on Advanced Detectors, La Biodola, Isola d'Elba, Ital

The origin recognition complex protein family

The proteins of the origin recognition complex are found throughout all eukaryotes and have roles beyond that of DNA replication

Long-term straw management and N fertilizer rate effects on soil organic C and N, and some chemical properties in a Black Chernozem

Non-Peer Reviewe

Horizontal gene transfer contributed to the evolution of extracellular surface structures

The single-cell layered ectoderm of the fresh water polyp Hydra fulfills the function of an epidermis by protecting the animals from the surrounding medium. Its outer surface is covered by a fibrous structure termed the cuticle layer, with similarity to the extracellular surface coats of mammalian epithelia. In this paper we have identified molecular components of the cuticle. We show that its outermost layer contains glycoproteins and glycosaminoglycans and we have identified chondroitin and chondroitin-6-sulfate chains. In a search for proteins that could be involved in organising this structure we found PPOD proteins and several members of a protein family containing only SWT (sweet tooth) domains. Structural analyses indicate that PPODs consist of two tandem β-trefoil domains with similarity to carbohydrate-binding sites found in lectins. Experimental evidence confirmed that PPODs can bind sulfated glycans and are secreted into the cuticle layer from granules localized under the apical surface of the ectodermal epithelial cells. PPODs are taxon-specific proteins which appear to have entered the Hydra genome by horizontal gene transfer from bacteria. Their acquisition at the time Hydra evolved from a marine ancestor may have been critical for the transition to the freshwater environment

Extra-corporeal membrane oxygenation in the management of 2009 influenza A (H1N1) refractory respiratory failure.

Rapidly progressive acute respiratory failure attributed to 2009 H1N1 influenza A infection has been reported worldwide-3. Refractory hypoxaemia despite conventional mechanical ventilation and lung protective strategies has resulted in the use a combination of rescue therapies, such as conservative fluid management, prone positioning, inhaled nitric oxide, high frequency oscillatory ventilation and extracorporeal membrane oxygenation (ECMO)4. ECMO allows for pulmonary or cardiopulmonary support as an adjunct to respiratory and cardiac failure, minimising ventilator-associated lung injury (VALI). This permits treatment of the underlying disease process, while concurrently allowing for recovery of the acute lung injury. This case documents a previously healthy twenty-two year old Asian male patient with confirmed pandemic (H 1N1) 2009 influenza A who was successfully managed with ECMO in the setting of severe refractory hypoxaemia and progressive hypercapnia

The art of being human : a project for general philosophy of science

Throughout the medieval and modern periods, in various sacred and secular guises, the unification of all forms of knowledge under the rubric of ‘science’ has been taken as the prerogative of humanity as a species. However, as our sense of species privilege has been called increasingly into question, so too has the very salience of ‘humanity’ and ‘science’ as general categories, let alone ones that might bear some essential relationship to each other. After showing how the ascendant Stanford School in the philosophy of science has contributed to this joint demystification of ‘humanity’ and ‘science’, I proceed on a more positive note to a conceptual framework for making sense of science as the art of being human. My understanding of ‘science’ is indebted to the red thread that runs from Christian theology through the Scientific Revolution and Enlightenment to the Humboldtian revival of the university as the site for the synthesis of knowledge as the culmination of self-development. Especially salient to this idea is science‘s epistemic capacity to manage modality (i.e. to determine the conditions under which possibilities can be actualised) and its political capacity to organize humanity into projects of universal concern. However, the challenge facing such an ideal in the twentyfirst century is that the predicate ‘human’ may be projected in three quite distinct ways, governed by what I call ‘ecological’, ‘biomedical’ and ‘cybernetic’ interests. Which one of these future humanities would claim today’s humans as proper ancestors and could these futures co-habit the same world thus become two important questions that general philosophy of science will need to address in the coming years

Seasonal and daytime variation in multiple immune parameters in humans: evidence from 329,261 participants of the UK Biobank Cohort

Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. Here we investigate seasonal and daytime variability in multiple immune parameters in 329,261 participants in UK Biobank, and test for associations with a wide range of environmental and lifestyle factors, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. Seasonal patterns were evident in lymphocyte and neutrophil counts, and CRP, but not monocytes, and these were independent of lifestyle, demographic and environmental factors. All the immune parameters assessed demonstrated significant daytime variation that was independent of confounding factors. At a population level, human immune parameters vary across season and across time of day, independent of multiple confounding factors. Both season and time of day are fundamental dimensions of immune function that should be considered in all studies of immuno-prophylaxis and disease transmission

Development of Crop.LCA, an adaptable screening life cycle assessment tool for agricultural systems: a Canadian scenario assessment

There is an increasing demand for sustainable agricultural production as part of the transition towards a globally sustainable economy. To quantify impacts of agricultural systems on the environment, life cycle assessment (LCA) is ideal because of its holistic approach. Many tools have been developed to conduct LCAs in agriculture, but they are not publicly available, not open-source, and have a limited scope. Here, a new adaptable open-source tool (Crop.LCA) for carrying out LCA of cropping systems is presented and tested in an evaluation study with a scenario assessment of 4 cropping systems using an agroecosystem model (DNDC) to predict soil GHG emissions. The functional units used are hectares (ha) of land and gigajoules (GJ) of harvested energy output, and 4 impact categories were evaluated: cumulative energy demand (CED), 100-year global warming potential (GWP), eutrophication and acidification potential. DNDC was used to simulate 28 years of cropping system dynamics, and the results were used as input in Crop.LCA. Data were aggregated for each 4-year rotation and statistically analyzed. Introduction of legumes into the cropping system reduced CED by 6%, GWP by 23%, and acidification by 19% per ha. These results highlight the ability of Crop.LCA to capture cropping system characteristics in LCA, and the tool constitutes a step forward in increasing the accuracy of LCA of cropping systems as required for bio-economy system assessments. Furthermore, the tool is open-source, highly transparent and has the necessary flexibility to assess agricultural systems

Development of Crop.LCA, an adaptable screening life cycle assessment tool for agricultural systems: a Canadian scenario assessment

There is an increasing demand for sustainable agricultural production as part of the transition towards a globally sustainable economy. To quantify impacts of agricultural systems on the environment, life cycle assessment (LCA) is ideal because of its holistic approach. Many tools have been developed to conduct LCAs in agriculture, but they are not publicly available, not open-source, and have a limited scope. Here, a new adaptable open-source tool (Crop.LCA) for carrying out LCA of cropping systems is presented and tested in an evaluation study with a scenario assessment of 4 cropping systems using an agroecosystem model (DNDC) to predict soil GHG emissions. The functional units used are hectares (ha) of land and gigajoules (GJ) of harvested energy output, and 4 impact categories were evaluated: cumulative energy demand (CED), 100-year global warming potential (GWP), eutrophication and acidification potential. DNDC was used to simulate 28 years of cropping system dynamics, and the results were used as input in Crop.LCA. Data were aggregated for each 4-year rotation and statistically analyzed. Introduction of legumes into the cropping system reduced CED by 6%, GWP by 23%, and acidification by 19% per ha. These results highlight the ability of Crop.LCA to capture cropping system characteristics in LCA, and the tool constitutes a step forward in increasing the accuracy of LCA of cropping systems as required for bio-economy system assessments. Furthermore, the tool is open-source, highly transparent and has the necessary flexibility to assess agricultural systems