17 research outputs found
Clinical and hygienic assessment of bone mineral density in population of ecologically contrasting territories.
Disorder of the relationship between biotic and abiotic elements against the background of anthropogenic stress on the human body affects the course of bone remodeling. It is bone tissue in the human body that has the greatest cumulative properties with respect to many xenobiotics, lead in particular. The accumulation of lead in the bone leads to the replacement of calcium ions by ions of the abiotic element and causes further changes in the bone structure: inhibition of growth processes, decreased density, the development of osteopenia and osteoporosis. In the article, a comparative hygienic analysis of bone mineral density levels (according to T-score) in industrial (n=68) and control (n=70) areas was conducted. The T-score, calculated at the LI-LIV level obtained by the method of dual-energy X-ray absorptiometry was used and was evaluated according to the recommendations of the WHO. The formation of a homogeneous sample of persons for the study was conducted according to the place of residence, age, sex, absence of diseases and regular intake of drugs leading to a decrease in bone mass. Summarizing the results, it should be noted that the population of DniprΠΎ city has a more negative and significant decrease in the bone mineral density (according to the T-score) compared to the same values of the control areas β 2.15-4.6 times and Ukraine's β 1.39-4.21 times. According to WHO recommendations, T-score indices for residents of industrial territory indicate to the presence of osteopenia, while among residents of the control area, the norm for this indicator is noted. Consequently, there is an effect of man-made including lead, pollution of the environment on the level of bone mineral density in the industrial city this contributes to the development of osteoporotic changes in the population
ΠΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½Π° Π΄ΡΡ ΡΠΈΠ½ΠΊΡ Π² ΠΌΠ°ΠΊΡΠΎ- Ρ Π½Π°Π½ΠΎΠ°ΠΊΠ²Π°Ρ Π΅Π»Π°ΡΠ½ΡΠΉ ΡΠΎΡΠΌΡ Π½Π° Π΅ΠΌΠ±ΡΡΠΎΠ³Π΅Π½Π΅Π· ΡΡΡΡΠ² Π·Π° ΡΠΌΠΎΠ²ΠΈ ΡΠ²ΠΈΠ½ΡΠ΅Π²ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ
The article presents results of studied influence of low doses of lead and zinc (nanozinc) on embryonal development in a laΒboratory experiment on rats. Β Negative influence of lead on pregnancy of laboratory animals, manifested in violation of the physiological dynamics of the rectal temperature and decrease in body weight gain was revealed. Embryotoxic efΒfect of low doses of lead results in increased fetal mortality by 2.16 times compared to the control group of animals, deΒterioration of the morphometric indices of fetuses, violation of placentogenesis. Simultaneous injections of zinc on backΒground of lead intoxication causes a protective effect on the body of pregnant rats and embryonal development of the offspring, more pronounced for zinc citrate, received by using aquananotehnology, as compared to zinc chloride. Thus, by morphometry indices, male fetuses were more sensitive to prenatal lead exposure in comparison to female fetuses.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½ΠΈΠ·ΠΊΠΈΡ
Π΄ΠΎΠ· ΡΠ²ΠΈΠ½ΡΠ° ΠΈ ΡΠΈΠ½ΠΊΠ° (Π½Π°Π½ΠΎΡΠΈΠ½ΠΊΠ°) Π½Π° ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Π½Π° ΠΊΡΡΡΠ°Ρ
. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠ΅ Π²Π»ΠΈΒΡΠ½ΠΈΠ΅ ΡΠ²ΠΈΠ½ΡΠ° Π½Π° ΠΏΡΠΎΡΠ΅ΠΊΠ°Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡΠΎ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π² Π½Π°ΡΡΡΠ΅Π½ΠΈΠΈ ΡΠΈΠ·ΠΈΠΎΒΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ ΠΏΡΠΈΡΠΎΡΡΠ° ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°. ΠΠΌΠ±ΡΠΈΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π½ΠΈΠ·ΠΊΠΈΡ
Π΄ΠΎΠ· ΡΠ²ΠΈΠ½ΡΠ° ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π² ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠΌΠ΅ΡΡΠ½ΠΎΡΡΠΈ Π² 2,16 ΡΠ°Π·Π° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΒΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
, ΡΡ
ΡΠ΄ΡΠ΅Π½ΠΈΠΈ ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠ»ΠΎΠ΄ΠΎΠ², Π½Π°ΡΡΡΠ΅Π½ΠΈΠΈ ΠΏΠ»Π°ΡΠ΅Π½ΒΡΠΎΠ³Π΅Π½Π΅Π·Π°. ΠΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΠΈΠ½ΠΊΠ° ΠΏΡΠΈ ΡΠ²ΠΈΠ½ΡΠΎΠ²ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΊΡΡΡ ΠΈ ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΠΎΡΠΎΠΌΡΡΠ²Π°, Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ΅ Π΄Π»Ρ ΡΠΈΡΒΡΠ°ΡΠ° ΡΠΈΠ½ΠΊΠ°, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π°ΠΊΠ²Π°Π½Π°Π½ΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Ρ
Π»ΠΎΡΠΈΠ΄ΠΎΠΌ ΡΠΈΠ½ΠΊΠ°. ΠΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎ ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΠΏΠ»ΠΎΠ΄Ρ ΠΌΡΠΆΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»Π° ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½Ρ ΠΊ ΠΏΡΠ΅Π½Π°ΡΠ°Π»ΡΠ½ΠΎΠΌΡ Π²ΠΎΠ·ΒΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²ΠΈΠ½ΡΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΠ»ΠΎΠ΄Π°ΠΌΠΈ ΠΆΠ΅Π½ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»Π°.Β The article presents results of studied influence of low doses of lead and zinc (nanozinc) on embryonal development in a laΒboratory experiment on rats. Β Negative influence of lead on pregnancy of laboratory animals, manifested in violation of the physiological dynamics of the rectal temperature and decrease in body weight gain was revealed. Embryotoxic efΒfect of low doses of lead results in increased fetal mortality by 2.16 times compared to the control group of animals, deΒterioration of the morphometric indices of fetuses, violation of placentogenesis. Simultaneous injections of zinc on backΒground of lead intoxication causes a protective effect on the body of pregnant rats and embryonal development of the offspring, more pronounced for zinc citrate, received by using aquananotehnology, as compared to zinc chloride. Thus, by morphometry indices, male fetuses were more sensitive to prenatal lead exposure in comparison to female fetuses
Scientific Justification of Risk Management System of Ecologically Caused Reproductive Pathology in Population.
The article presents the results of development of system of measures β a conceptual model of risk management of environmentally induced reproductive pathology in the population, which includes a complex of interdependent staged measures: ecological and hygienic monitoring, characteristics of environmental safety, study of social component of ecological safety, hygienic diagnosis of the impact of environmental factors on the social dimension of environmental safety, hygiene forecasting, implementation of preventive measures, assessment of their quality and efficiency. It was established that an important component of measures of medical and biological preΒvention is early diagnosis and prediction of violations of trace element status, childbearing potential, reproductive disorΒders in population using predictive models and calculated criteria values of markers of exposure, as well as hygienic determinants of reproductive health. It is proved that the use ofpectin preparations and organic forms of zinc for elimination of xenobiotics is a highly effective means, which normalizes trace element status and prevents pre-nosologic changes in the generative system of a person, reduces incidence of reproductive disorders
Translocation of Trace Elements in the System "Mother-placenta-fetus" in Rats with Physiological Pregnancy and Under Conditions of Lead Exposure.
Heavy metals are the second major environmental pollutants. Especially toxic is lead, increased content of which in the body of a pregnant determines the development of pregnancy, childbirth and postpartum period complications and is potentiated by deficiency of essential trace elements - zinc and copper. Article presents the results of impact of solutions of lead acetate and citrate in experimental models. Solutions of metals were injected into the stomach through a tube once a day during 19 days of pregnancy in the dose of 0,05 mg/kg in the form of inorganic compound - lead acetate and in organic form β lead citrate. The content of trace elements - lead, cadmium, copper and zinc were determined by stripping voltamperometry. In addition, indices of placental and fetal accumulation, as well as index of transplacental migration were calculated. Effect of lead during pregnancy in all biosubstrates is increased by 1,3-1,9 times as compared with the control group. This causes imbalance of essential trace elements due to significant reduction in zinc content in all the studied biological substrates. Prolonged contact with lead during pregnancy leads to disruption of placenta, inability of the placenta to fully protect the fetus from excessive intranatal influence of xenobiotics
ΠΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½Π° Π΄ΡΡ Π½ΠΈΠ·ΡΠΊΠΎΠ΄ΠΎΠ·ΠΎΠ²ΠΈΡ ΡΡΠ²Π½ΡΠ² ΡΠ²ΠΈΠ½ΡΡ ΡΠ° ΡΠΈΠ½ΠΊΡ Π½Π° ΠΊΡΡΡΠΊΠΎΠ²Ρ ΡΠΊΠ°Π½ΠΈΠ½Ρ ΡΡΡΡΠ²
Pollution of the environment remains a pressing problem of the global level. The greatest concern is caused by heavy metals, especially lead, which to the greatest extent - up to 90β95 % accumulates in bone tissue of the human body.Aim. The establishment of the bioeffect type of low-dose lead and zinc combined action on bone tissue density by the calcium content in it in the experiment.Materials and methods. For experimental studies Wistar rats were divided into 5 groups. To determine the type of lead and zinc effect on the calcium level in femur bone tissue the content of the latter by the titration method was identified. To evaluate the relationship between low doses of zinc and lead, the combined action coefficient and change of combined action effect coefficient were determined.Results. The analysis of the results shows that the type of lead and zinc low concentrations combined action in their influence on bone tissue density by calcium content in it is characterized as an antagonistic, since the combined action coefficient value was 0.32β0.39. The effect of subacute combined action in binary systems "lead acetate β zinc chloride" and "lead acetate β zinc citrate" is weakened by 2.6 and 3.1 times, respectively.Conclusions. The type of lead and zinc low concentrations combined action provided that they affect the bone tissue density of rats by calcium content in it, which do not exceed the threshold of general toxicity, is characterized as antagonistic, since the combined action coefficient = 0.32β0.39. The effect of subacute combined action in binary systems, "lead acetate β zinc chloride" and "lead acetate β zinc citrate" is reduced by 2.6 and 3.1 times, respectively, compared with their isolated effects, indicating active inhibition of bone tissue lead accumulation by zinc compounds, which is especially characteristic of zinc citrate.ΠΠ°Π³ΡΡΠ·Π½Π΅Π½ΠΈΠ΅ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ ΠΏΠΎ-ΠΏΡΠ΅ΠΆΠ½Π΅ΠΌΡ ΠΎΡΡΠ°Π΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ Π±Π΅ΡΠΏΠΎΠΊΠΎΠΉΡΡΠ²ΠΎ Π²ΡΠ·ΡΠ²Π°ΡΡ ΡΡΠΆΠ΅Π»ΡΠ΅ ΠΌΠ΅ΡΠ°Π»Π»Ρ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΠ²ΠΈΠ½Π΅Ρ, ΠΊΠΎΡΠΎΡΡΠΉ Π² Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ β Π΄ΠΎ 90β95 %, Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°Π΅ΡΡΡ Π² ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΈΠΏΠ° Π±ΠΈΠΎΡΡΡΠ΅ΠΊΡΠ° ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½ΠΈΠ·ΠΊΠΎΠ΄ΠΎΠ·ΠΎΠ²ΡΡ
ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠ²ΠΈΠ½ΡΠ° ΠΈ ΡΠΈΠ½ΠΊΠ° Π½Π° ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² Π½Π΅ΠΉ ΠΊΠ°Π»ΡΡΠΈΡ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΊΡΡΡ Π»ΠΈΠ½ΠΈΠΈ Wistar Π½Π° 5 Π³ΡΡΠΏΠΏ. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΈΠΏΠ° Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²ΠΈΠ½ΡΠ° ΠΈ ΡΠΈΠ½ΠΊΠ° Π½Π° ΡΡΠΎΠ²Π΅Π½Ρ ΠΊΠ°Π»ΡΡΠΈΡ Π² ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π±Π΅Π΄ΡΠ΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΈΡΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠ»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΉ Π½ΠΈΠ·ΠΊΠΈΡ
Π΄ΠΎΠ· ΡΠΈΠ½ΠΊΠ° ΡΠΎ ΡΠ²ΠΈΠ½ΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ (ΠΠΊΠ΄) ΠΈ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠ° ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ (ΠΠΈΡ).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ, ΡΡΠΎ ΡΠΈΠΏ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²ΠΈΠ½ΡΠ° ΠΈ ΡΠΈΠ½ΠΊΠ° ΠΏΡΠΈ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΠΈ Π½Π° ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² Π½Π΅ΠΉ ΠΊΠ°Π»ΡΡΠΈΡ Π² Π½ΠΈΠ·ΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΠΠΊΠ΄ ΡΠΎΡΡΠ°Π²Π»ΡΠ»Π° 0,32β0,39. ΠΡΡΠ΅ΠΊΡ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π² Π±ΠΈΠ½Π°ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΠ° β Ρ
Π»ΠΎΡΠΈΠ΄ ΡΠΈΠ½ΠΊΠ°Β» ΠΈ Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΠ° β ΡΠΈΡΡΠ°Ρ ΡΠΈΠ½ΠΊΠ°Β» ΠΎΡΠ»Π°Π±Π»Π΅Π½ Π² 2,6 ΠΈ 3,1 ΡΠ°Π·Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ.ΠΡΠ²ΠΎΠ΄Ρ. Π’ΠΈΠΏ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ²ΠΈΠ½ΡΠ° ΠΈ ΡΠΈΠ½ΠΊΠ° Π² Π½ΠΈΠ·ΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
, ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΊΡΡΡ ΠΏΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² Π½Π΅ΠΉ ΠΊΠ°Π»ΡΡΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡ ΠΏΠΎΡΠΎΠ³ ΠΎΠ±ΡΠ΅ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΠΠΊΠ΄ = 0,32β0,39. ΠΡΡΠ΅ΠΊΡ ΠΏΠΎΠ΄ΠΎΡΡΡΠΎΠ³ΠΎ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π² Π±ΠΈΠ½Π°ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΠ° β Ρ
Π»ΠΎΡΠΈΠ΄ ΡΠΈΠ½ΠΊΠ°Β» ΠΈ Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΠ° β ΡΠΈΡΡΠ°Ρ ΡΠΈΠ½ΠΊΠ°Β» ΡΠΌΠ΅Π½ΡΡΠ°Π΅ΡΡΡ Π² 2,6 ΠΈ 3,1 ΡΠ°Π·Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ, ΡΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± Π°ΠΊΡΠΈΠ²Π½ΠΎΠΌ ΡΠΎΡΠΌΠΎΠΆΠ΅Π½ΠΈΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΠΌΠΈ ΡΠΈΠ½ΠΊΠ° Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ ΡΠ²ΠΈΠ½ΡΠ° ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΡΡ, ΡΡΠΎ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ Π΄Π»Ρ ΡΠΈΡΡΠ°ΡΠ° ΡΠΈΠ½ΠΊΠ°.ΠΠ°Π±ΡΡΠ΄Π½Π΅Π½Π½Ρ Π΄ΠΎΠ²ΠΊΡΠ»Π»Ρ, ΡΠΊ Ρ ΡΠ°Π½ΡΡΠ΅, Π·Π°Π»ΠΈΡΠ°ΡΡΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΡ Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ²Π½Ρ. ΠΠ°ΠΉΠ±ΡΠ»ΡΡΠ΅ Π·Π°Π½Π΅ΠΏΠΎΠΊΠΎΡΠ½Π½Ρ Π²ΠΈΠΊΠ»ΠΈΠΊΠ°ΡΡΡ Π²Π°ΠΆΠΊΡ ΠΌΠ΅ΡΠ°Π»ΠΈ, ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎ ΡΠ²ΠΈΠ½Π΅ΡΡ, ΡΠΊΠΈΠΉ Π½Π°ΠΉΠ±ΡΠ»ΡΡΠ΅ β Π΄ΠΎ 90β95 %, Π½Π°ΠΊΠΎΠΏΠΈΡΡΡΡΡΡΡ Π² ΠΊΡΡΡΠΊΠΎΠ²ΡΠΉ ΡΠΊΠ°Π½ΠΈΠ½Ρ ΠΎΡΠ³Π°Π½ΡΠ·ΠΌΡ Π»ΡΠ΄ΠΈΠ½ΠΈ.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ β Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½Ρ ΡΠΈΠΏΡ Π±ΡΠΎΠ΅ΡΠ΅ΠΊΡΡ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ Π½ΠΈΠ·ΡΠΊΠΎΠ΄ΠΎΠ·ΠΎΠ²ΠΈΡ
ΡΡΠ²Π½ΡΠ² ΡΠ²ΠΈΠ½ΡΡ ΡΠ° ΡΠΈΠ½ΠΊΡ Π½Π° ΡΡΠ»ΡΠ½ΡΡΡΡ ΠΊΡΡΡΠΊΠΎΠ²ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Π·Π° Π²ΠΌΡΡΡΠΎΠΌ Ρ Π½ΡΠΉ ΠΊΠ°Π»ΡΡΡΡ Π² Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ»Ρ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΡΠΎΠ·ΠΏΠΎΠ΄ΡΠ»ΠΈΠ»ΠΈ ΡΡΡΡΠ² Π»ΡΠ½ΡΡ Wistar Π½Π° 5 Π³ΡΡΠΏ. ΠΠ»Ρ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ ΡΠΈΠΏΡ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΠ²ΠΈΠ½ΡΡ ΡΠ° ΡΠΈΠ½ΠΊΡ Π½Π° ΡΡΠ²Π΅Π½Ρ ΠΊΠ°Π»ΡΡΡΡ Π² ΠΊΡΡΡΠΊΠΎΠ²ΡΠΉ ΡΠΊΠ°Π½ΠΈΠ½Ρ ΡΡΠ΅Π³Π½ΠΎΠ²ΠΎΡ ΠΊΡΡΡΠΊΠΈ Π²ΠΈΠ·Π½Π°ΡΠΈΠ»ΠΈ ΠΊΡΠ»ΡΠΊΡΡΡΡ ΠΎΡΡΠ°Π½Π½ΡΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΈΡΡΡΠ²Π°Π½Π½Ρ. ΠΠ»Ρ ΠΎΡΡΠ½ΡΠ²Π°Π½Π½Ρ Π²ΡΠ΄Π½ΠΎΡΠΈΠ½ Π½ΠΈΠ·ΡΠΊΠΈΡ
Π΄ΠΎΠ· ΡΠΈΠ½ΠΊΡ Π·Ρ ΡΠ²ΠΈΠ½ΡΠ΅ΠΌ Π²ΠΈΠ·Π½Π°ΡΠΈΠ»ΠΈ ΠΊΠΎΠ΅ΡΡΡΡΡΠ½Ρ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ (ΠΠΊΠ΄) Ρ ΠΊΠΎΠ΅ΡΡΡΡΡΠ½Ρ Π·ΠΌΡΠ½ΠΈ Π΅ΡΠ΅ΠΊΡΡ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ (ΠΠ·Π΅).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. ΠΠ½Π°Π»ΡΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΠ² ΡΠ²ΡΠ΄ΡΠΈΡΡ, ΡΠΎ ΡΠΈΠΏ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ ΡΠ²ΠΈΠ½ΡΡ ΡΠ° ΡΠΈΠ½ΠΊΡ Π·Π° ΡΠΌΠΎΠ²ΠΈ ΡΡ
Π½ΡΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ Π½Π° ΡΡΠ»ΡΠ½ΡΡΡΡ ΠΊΡΡΡΠΊΠΎΠ²ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Π·Π° Π²ΠΌΡΡΡΠΎΠΌ Ρ Π½ΡΠΉ ΠΊΠ°Π»ΡΡΡΡ Π² Π½ΠΈΠ·ΡΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡΡ ΡΠΊ Π°Π½ΡΠ°Π³ΠΎΠ½ΡΡΡΠΈΡΠ½ΠΈΠΉ, ΠΎΡΠΊΡΠ»ΡΠΊΠΈ Π²Π΅Π»ΠΈΡΠΈΠ½Π° ΠΠΊΠ΄ ΡΡΠ°Π½ΠΎΠ²ΠΈΠ»Π° 0,32β0,39. ΠΡΠ΅ΠΊΡ ΠΏΡΠ΄Π³ΠΎΡΡΡΠΎΡ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ Π² Π±ΡΠ½Π°ΡΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΡ β Ρ
Π»ΠΎΡΠΈΠ΄ ΡΠΈΠ½ΠΊΡΒ» ΡΠ° Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΡ β ΡΠΈΡΡΠ°Ρ ΡΠΈΠ½ΠΊΡΒ» ΠΎΡΠ»Π°Π±Π»Π΅Π½ΠΈΠΉ Ρ 2,6 Ρ 3,1 ΡΠ°Π·Π° Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π’ΠΈΠΏ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ ΡΠ²ΠΈΠ½ΡΡ ΡΠ° ΡΠΈΠ½ΠΊΡ Π² Π½ΠΈΠ·ΡΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡΡ
, Π·Π° ΡΠΌΠΎΠ²ΠΈ ΡΡ
Π½ΡΠΎΠ³ΠΎ Π²ΠΏΠ»ΠΈΠ²Ρ Π½Π° ΡΡΠ»ΡΠ½ΡΡΡΡ ΠΊΡΡΡΠΊΠΎΠ²ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ ΡΡΡΡΠ² Π·Π° Π²ΠΌΡΡΡΠΎΠΌ Ρ Π½ΡΠΉ ΠΊΠ°Π»ΡΡΡΡ, ΠΊΠΎΡΡΡ Π½Π΅ ΠΏΠ΅ΡΠ΅Π²ΠΈΡΡΡΡΡ ΠΏΠΎΡΡΠ³ Π·Π°Π³Π°Π»ΡΠ½ΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡ Π΄ΡΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡΡ ΡΠΊ Π°Π½ΡΠ°Π³ΠΎΠ½ΡΡΡΠΈΡΠ½ΠΈΠΉ, ΠΎΡΠΊΡΠ»ΡΠΊΠΈ ΠΠΊΠ΄ = 0,32β0,39. ΠΡΠ΅ΠΊΡ ΠΏΡΠ΄Π³ΠΎΡΡΡΠΎΡ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ Π² Π±ΡΠ½Π°ΡΠ½ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΡ β Ρ
Π»ΠΎΡΠΈΠ΄ ΡΠΈΠ½ΠΊΡΒ» ΡΠ° Β«Π°ΡΠ΅ΡΠ°Ρ ΡΠ²ΠΈΠ½ΡΡ β ΡΠΈΡΡΠ°Ρ ΡΠΈΠ½ΠΊΡΒ» Π·ΠΌΠ΅Π½ΡΡΡΡΡΡΡ Ρ 2,6 Ρ 3,1 ΡΠ°Π·Π° Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΎ, ΠΏΠΎΡΡΠ²Π½ΡΠ½ΠΎ Π· ΡΠ·ΠΎΠ»ΡΠΎΠ²Π°Π½ΠΈΠΌ ΡΡ
Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ, ΡΠΎ ΡΠ²ΡΠ΄ΡΠΈΡΡ ΠΏΡΠΎ Π°ΠΊΡΠΈΠ²Π½Π΅ Π³Π°Π»ΡΠΌΡΠ²Π°Π½Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠ°ΠΌΠΈ ΡΠΈΠ½ΠΊΡ Π½Π°ΠΊΠΎΠΏΠΈΡΠ΅Π½Π½Ρ ΡΠ²ΠΈΠ½ΡΡ ΠΊΡΡΡΠΊΠΎΠ²ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΎΡ ΡΠ° Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΈΠΌ Π΄Π»Ρ ΡΠΈΡΡΠ°ΡΡ ΡΠΈΠ½ΠΊΡ
Combined effect of low dose levels of lead and zinc on bone tissue of rats
Pollution of the environment remains a pressing problem of the global level. The greatest concern is caused by heavy metals, especially lead, which to the greatest extent - up to 90β95 % accumulates in bone tissue of the human body.
Aim. The establishment of the bioeffect type of low-dose lead and zinc combined action on bone tissue density by the calcium content in it in the experiment.
Materials and methods. For experimental studies Wistar rats were divided into 5 groups. To determine the type of lead and zinc effect on the calcium level in femur bone tissue the content of the latter by the titration method was identified. To evaluate the relationship between low doses of zinc and lead, the combined action coefficient and change of combined action effect coefficient were determined.
Results. The analysis of the results shows that the type of lead and zinc low concentrations combined action in their influence on bone tissue density by calcium content in it is characterized as an antagonistic, since the combined action coefficient value was 0.32β0.39. The effect of subacute combined action in binary systems "lead acetate β zinc chloride" and "lead acetate β zinc citrate" is weakened by 2.6 and 3.1 times, respectively.
Conclusions. The type of lead and zinc low concentrations combined action provided that they affect the bone tissue density of rats by calcium content in it, which do not exceed the threshold of general toxicity, is characterized as antagonistic, since the combined action coefficient = 0.32β0.39. The effect of subacute combined action in binary systems, "lead acetate β zinc chloride" and "lead acetate β zinc citrate" is reduced by 2.6 and 3.1 times, respectively, compared with their isolated effects, indicating active inhibition of bone tissue lead accumulation by zinc compounds, which is especially characteristic of zinc citrate
LEP Ceremony
The article is devoted to modern aspects of technogenic pollution of atmospheric air of industrial city in connection with the activity of the largest metallurgical enterprise in Ukraine - Dneprovsky metallurgical combine. The peculiarity of this scientific research is the use of a comprehensive and systemic ecological and hygienic approach: by-ingredient and summary hygienic assessment of technogenic pollution of the atmospheric air layer in the city, its spatial and temporal characteristics in the dynamics of a 30-yearsβ period with an emphasis on the last five years, considering quantitative relationship with the volumes of gross industrial atmospheric emissions and their distribution on the territory of the city was performed, as well as mathematical calculations and hygienic assessment of risk to the health of the city population were made
Comparative Evaluation of Bioprotective Action of Zinc in Organic and Inorganic Form on Osteotropism of Lead in Experimental Conditions.
Chemical aggression of technogenic pollution of the environment, according to experts, is the leading risk factor for population health. A systematic entry of contaminants in the related life-supporting environments β air, water, plant and animal food products by direct and indirect migration chains creates both integrated and combined effect on the body. It should be noted that a chemical factor, on the one hand, is the least studied in this respect, on the other hand it represents the most significant and rapidly growing environmental threat to human health. In the human body bone tissue has the highest cumulative properties against many xenobiotics, in particular to heavy metals, among which lead is the leader in relationship to the bone tissue. In this regard, the goal is to study peculiarities of different forms of zinc on calcium content in bone tissue in lead intoxication. As a result of researches it is established that low dosed effect of lead during subacute experience causes a significant decrease of calcium content in the bone tissue by 28% in comparison with those of control group of animals, this reduces its density and becomes a risk factor for the development of osteopenic and osteoporotic state of the organism. Combined effect of lead and organic and inorganic forms of zinc zeliably increases calcium content by 16.43% and 22,04% respectively, as compared with lead group, suggesting protective properties of zinc in lead intoxication due to the effect of bioantagonism. In the isolated introduction of organic and inorganic forms of zinc, calcium content in the bone tissue increases by 1.4 and 2.04 times respectively, as compared with the control group. The obtained results confirm osteoprotective action of zinc, particularly of organic forms in lead intoxication and give reason to believe that in the system "lead β zinc" effect of biological antagonism is formed
Reproductive Health of Men of Industrial Areas: Risk Factors, Donosological Diagnostics, Prevention.
Deterioration of the environment in the XX-XXI century under the influence of chemical, physical, radiological and other factors is not only and not just an ecological catastrophe of modern times, but a direct threat to the health and life of human society as a whole. Among the most important factors influencing people's health occupy chemical the leading place, because since 1957 more than 50 million chemical substances were synthesized, but only 15% of them have a toxicological evaluation, and 30% of the diseases in Europe are associated with chemical factor (ECHA-EXA). Chemical "pressing" determines a significant reduction in the reproduction of the population of Europe, and for Ukraine itmeans a large-scale depopulation, among possible reasons of which a significant role belongs to the deterioration of the reproductive capacity of population, men in particular, and this work is devoted to this problem. On the basis of profound analysis of literature data, complex ecologic-hygienic researches we identified markers of exposure, prognosticaly significant markers of impact for the early diagnostics of disorders of male generative system in conditions of low-dose impact of xenobiotics. We achieved convincing evidence of ecologically determined character of unogenital diseases and fertility decrease, we developed scientifically-justified principles of management of risk of development of ecologically-determined reproductive pathology in men