6,720 research outputs found
Prototype tests for the ALICE TRD
A Transition Radiation Detector (TRD) has been designed to improve the
electron identification and trigger capability of the ALICE experiment at the
Large Hadron Collider (LHC) at CERN. We present results from tests of a
prototype of the TRD concerning pion rejection for different methods of
analysis over a momentum range from 0.7 to 2 GeV/c. We investigate the
performance of different radiator types, composed of foils, fibres and foams.Comment: Presented at the IEEE Nuclear Science Symposium and Medical Imaging
Conference, Lyon, October 15-20, 2000 (accepted for publication in IEEE TNS),
Latex (IEEEtran.cls), 7 pages, 11 eps figure
Two-pion correlations in Au+Au collisions at 10.8 GeV/c per nucleon
Two-particle correlation functions for positive and negative pions have been
measured in Au+Au collisions at 10.8~GeV/c per nucleon. The data were analyzed
using one- and three-dimensional correlation functions. From the results of the
three-dimensional fit the phase space density of pions was calculated. It is
consistent with local thermal equilibrium.Comment: 5 pages RevTeX (including 3 Figures
Extending the viability of human precision-cut intestinal slice model for drug metabolism studies
Human Precision-cut intestinal slices (hPCIS) are used to study intestinal physiology, pathophysiology, drug efficacy, toxicology, kinetics, and metabolism. However, the use of this ex vivo model is restricted to approximately a 24 h timeframe because of declining viability of the hPCIS during traditional culture. We hypothesized that we could extend the hPCIS viability by using organoid medium. Therefore, we cultured hPCIS for up to 72 h in organoid media [expansion medium (Emed) and differentiation medium (Dmed)]. After incubation, we assessed culture-induced changes on viability markers, specific cell type markers and we assessed the metabolic activity of enterocytes by measuring midazolam metabolite formation. We show that the adenosine triphosphate (ATP)/protein ratio of Emed-cultured hPCIS and morphology of both Emed- and Dmed-cultured hPCIS was improved compared to WME-cultured hPCIS. Emed-cultured hPCIS showed an increased expression of proliferation and stem cell markers, whereas Dmed-cultured hPCIS showed an increased expression of proliferation and enterocyte markers, along with increased midazolam metabolism. Using the Emed, the viability of hPCIS could be extended for up to 72 h, and proliferating stem cells remained preserved. Using Dmed, hPCS also remained viable for up to 72 h, and specifically rescued the metabolizing enterocytes during culture. In conclusion, by using two different organoid culture media, we could extend the hPCIS viability for up to 72 h of incubation and specifically steer stem cells or enterocytes towards their original function, metabolism, and proliferation, potentially allowing pharmacokinetic and toxicology studies beyond the 24 h timeframe
Proton and Pion Production in Au+Au Collisions at 10.8A GeV/c
We present proton and pion tranverse momentum spectra and rapidity
distributions for Au+Au collisions at 10.8A GeV/c. The proton spectra exhibit
collective transverse flow effects. Evidence of the influence of the Coulomb
interaction from the fireball is found in the pion transverse momentum spectra.
The data are compared with the predictions of the RQMD event generator.Comment: plain tex (revtex), 24 pages Submitted to Phys. Rev.
Numerical study of the glass-glass transition in short-ranged attractive colloids
We report extensive numerical simulations in the {\it glass} region for a
simple model of short-ranged attractive colloids, the square well model. We
investigate the behavior of the density autocorrelation function and of the
static structure factor in the region of temperatures and packing fractions
where a glass-glass transition is expected according to theoretical
predictions. We strengthen our observations by studying both waiting time and
history dependence of the numerical results. We provide evidence supporting the
possibility that activated bond-breaking processes destabilize the attractive
glass, preventing the full observation of a sharp glass-glass kinetic
transition.Comment: 15 pages, 9 figures; Proceedings of "Structural Arrest Transitions in
Colloidal Systems with Short-Range Attractions", Messina, Italy, December
2003 (submitted to J. Phys.: Condens. Matt.
Directed flow of antiprotons in Au+Au collisions at AGS
Directed flow of antiprotons is studied in Au+Au collisions at a beam
momentum of 11.5A GeV/c. It is shown that antiproton directed flow is
anti-correlated to proton flow. The measured transverse momentum dependence of
the antiproton flow is compared with predictions of the RQMD event generator.Comment: 16 pages, 6 figure
Charged Particle Pseudorapidity Distributions in Au+Al, Cu, Au, and U Collisions at 10.8 AGeV/c
We present the results of an analysis of charged particle pseudorapidity
distributions in the central region in collisions of a Au projectile with Al,
Cu, Au, and U targets at an incident energy of 10.8~GeV/c per nucleon. The
pseudorapidity distributions are presented as a function of transverse energy
produced in the target or central pseudorapidity regions. The correlation
between charged multiplicity and transverse energy measured in the central
region, as well as the target and projectile regions is also presented. We give
results for transverse energy per charged particle as a function of
pseudorapidity and centrality.Comment: 31 pages + 12 figures (compressed and uuencoded by uufiles), LATEX,
Submitted to PR
Transition Radiation Spectroscopy with Prototypes of the ALICE TRD
We present measurements of the transition radiation (TR) spectrum produced in
an irregular radiator at different electron momenta. The data are compared to
simulations of TR from a regular radiator.Comment: 4 pages, 5 Figures, Proceedings for "TRDs for the 3rd millennium"
(Sept. 4-7, 2003, Bari, Italy
Clinical outcomes, return to sport, and complications after isolated primary Latarjet versus Latarjet as a revision procedure: A systematic review and meta-analysis
BACKGROUND: The purpose of this review was to compare clinical outcomes, return to sport (RTS), and complications in comparative studies examining patients undergoing primary Latarjet procedure versus Latarjet in the revision setting following soft tissue stabilization.
METHODS: A literature search was conducted using PubMed and Scopus databases using Preferred Reporting Items for Systematic Meta-Analyses guidelines. Inclusion criteria consisted of level I to III human clinical studies reporting clinical outcomes (Visual Analogue Pain Scale [VAS]), RTS metrics, and complications in patients following primary versus revision Latarjet procedures. Study quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) criteria.
RESULTS: A total of seven studies, consisting of 1170 patients (n=1179 shoulders) with a mean age of 26.4 years, consisting of 91.9% males (n=1083/1179 shoulders), were identified. Mean final follow-up was 46.4 (mean range, 7.3-72.2) months. A total of 748 primary and 431 revision Latarjet procedures were analyzed. Complications were reported in 9.6% (range, 0%-24.2%) of patients undergoing primary and 20.2% (range, 0%-40.7%) in patients undergoing revision procedures (p=0.22). There was no significant difference in the RTS rate between patients undergoing primary (87.3%; range, 83.8%-92.1%) versus Latarjet as a revision procedure (78.9%; range, 60%-100%) (p=0.08). Moreover, no significant difference in postoperative VAS was observed in patients undergoing primary versus Latarjet as a revision procedure (p=0.21). Recurrent shoulder subluxation was significantly greater in patients undergoing revision (12.0%; n=31/259 shoulders; range, 0%-20.7%) compared to primary procedures (3.3%; n=27/511 shoulders; range, 0%-9%) (p\u3c0.001).
DISCUSSION: Patients undergoing primary and revision Latarjet demonstrated overall similar rates of complications and return to sport. Of clinical importance, Latarjet as a revision procedure possessed a risk of recurrent subluxation 3.6 times higher than primary Latarjet. While effective, patients should be counseled regarding the differing prognosis between Latarjet as a primary or revision procedure.
LEVEL OF EVIDENCE: III; Systematic review and meta-analysis
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