The health and sport engagement (HASE) intervention and evaluation project: protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity.

INTRODUCTION: Sport is being promoted to raise population levels of physical activity for health. National sport participation policy focuses on complex community provision tailored to diverse local users. Few quality research studies exist that examine the role of community sport interventions in raising physical activity levels and no research to date has examined the costs and cost-effectiveness of such provision. This study is a protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity, the Health and Sport Engagement (HASE) project part of the national Get Healthy Get Active programme led by Sport England. METHODS AND ANALYSIS: The HASE study is a collaborative partnership between local community sport deliverers and sport and public health researchers. It involves designing, delivering and evaluating community sport interventions. The aim is to engage previously inactive people in sustained sporting activity for 1×30 min a week and to examine associated health and well-being outcomes. The study uses mixed methods. Outcomes (physical activity, health, well-being costs to individuals) will be measured by a series of self-report questionnaires and attendance data and evaluated using interrupted time series analysis controlling for a range of sociodemographic factors. Resource use will be identified and measured using diaries, interviews and records and presented alongside effectiveness data as incremental cost-effectiveness ratios and cost-effectiveness acceptability curves. A longitudinal process evaluation (focus groups, structured observations, in-depth interview methods) will examine the efficacy of the project for achieving its aim using the principles of thematic analysis. ETHICS AND DISSEMINATION: The results of this study will be disseminated through peer-reviewed publications, academic conference presentations, Sport England and national public health organisation policy conferences, and practice-based case studies. Ethical approval was obtained through Brunel University London's research ethics committee (reference number RE33-12)

Management of hyperlipidaemia

Copyright © 2005 Royal Australian College of General Practitioners Copyright to Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.BACKGROUND: Hyperlipidaemia is a general term for elevated concentrations of any or all lipids in the plasma. An elevated cholesterol is one of several risk factors for coronary heart disease (CHD). In Australia, the use of cholesterol lowering drugs, mainly statins, consumes over $880 million or 16% of the Pharmaceutical Benefits Scheme drug budget and is growing. OBJECTIVE: This article focusses on primary hypercholesterolaemia, its relationship with CHD, and its management in the community setting. DISCUSSION There is strong evidence that treating middle aged men with statins who have established CHD will reduce overall mortality, CHD morbidity, or mortality and stroke. There is weaker but reasonable evidence for treating men aged over 65 years and women of any age who have CHD, or people without CHD but at high risk. There may be some benefits for patients with stroke and peripheral vascular disease who are at risk of CHD. While discontinuation rates are high, the occurrence of serious adverse reactions are infrequent.Nigel Stocks, James Allan and Peter R. Mansfiel

Changes in subjective ratings of impulsive steering wheel vibration due to changes in noise level: a cross-modal interaction

Cross-modal effects occur when subjective opinions of stimuli from one sense (e.g., tactile at steering wheel) are influenced by simultaneous stimuli in another sense (auditory). A steering wheel rig was used to provide specified vibration stimuli to participants' hands, and a recording of vehicle sound was played in accordance with the vibrations. Participants were subjected to test conditions with vibration values between 10 m s and 20 m s, and auditory stimuli between 88 dB(A) and 98 dB(A) peak. Participants were neither informed of nor asked about any changes in the noise level: thus the purpose of the experiment was withheld from them. The results show that as noise level increased, subjective ratings of steering wheel vibration increased. Therefore, car cabin noise could be used to enhance the feel of the vibration at the steering wheel

Quantum entanglement between a nonlinear nanomechanical resonator and a microwave field

We consider a theoretical model for a nonlinear nanomechanical resonator coupled to a superconducting microwave resonator. The nanomechanical resonator is driven parametrically at twice its resonance frequency, while the superconducting microwave resonator is driven with two tones that differ in frequency by an amount equal to the parametric driving frequency. We show that the semi-classical approximation of this system has an interesting fixed point bifurcation structure. In the semi-classical dynamics a transition from stable fixed points to limit cycles is observed as one moves from positive to negative detuning. We show that signatures of this bifurcation structure are also present in the full dissipative quantum system and further show that it leads to mixed state entanglement between the nanomechanical resonator and the microwave cavity in the dissipative quantum system that is a maximum close to the semi-classical bifurcation. Quantum signatures of the semi-classical limit-cycles are presented.Comment: 36 pages, 18 figure

Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice

Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleto

Optimal strategies for a game on amenable semigroups

The semigroup game is a two-person zero-sum game defined on a semigroup S as follows: Players 1 and 2 choose elements x and y in S, respectively, and player 1 receives a payoff f(xy) defined by a function f from S to [-1,1]. If the semigroup is amenable in the sense of Day and von Neumann, one can extend the set of classical strategies, namely countably additive probability measures on S, to include some finitely additive measures in a natural way. This extended game has a value and the players have optimal strategies. This theorem extends previous results for the multiplication game on a compact group or on the positive integers with a specific payoff. We also prove that the procedure of extending the set of allowed strategies preserves classical solutions: if a semigroup game has a classical solution, this solution solves also the extended game.Comment: 17 pages. To appear in International Journal of Game Theor

Rim curvature anomaly in thin conical sheets revisited

This paper revisits one of the puzzling behaviors in a developable cone (d-cone), the shape obtained by pushing a thin sheet into a circular container of radius $R$ by a distance $\eta$ [E. Cerda, S. Chaieb, F. Melo, and L. Mahadevan, {\sl Nature} {\bf 401}, 46 (1999)]. The mean curvature was reported to vanish at the rim where the d-cone is supported [T. Liang and T. A. Witten, {\sl Phys. Rev. E} {\bf 73}, 046604 (2006)]. We investigate the ratio of the two principal curvatures versus sheet thickness $h$ over a wider dynamic range than was used previously, holding $R$ and $\eta$ fixed. Instead of tending towards 1 as suggested by previous work, the ratio scales as $(h/R)^{1/3}$. Thus the mean curvature does not vanish for very thin sheets as previously claimed. Moreover, we find that the normalized rim profile of radial curvature in a d-cone is identical to that in a "c-cone" which is made by pushing a regular cone into a circular container. In both c-cones and d-cones, the ratio of the principal curvatures at the rim scales as $(R/h)^{5/2}F/(YR^{2})$, where $F$ is the pushing force and $Y$ is the Young's modulus. Scaling arguments and analytical solutions confirm the numerical results.Comment: 25 pages, 12 figures. Added references. Corrected typos. Results unchange

The in vitro effects of heat shock protein 65 kDa on proliferation of A7r5 smooth muscle cells

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Light-Cone Quantization of the Liouville Model

We present the quantization of the Liouville model defined in light-cone coordinates in (1,1) signature space. We take advantage of the representation of the Liouville field by the free field of the Backl\"{u}nd transformation and adapt the approch by Braaten, Curtright and Thorn. Quantum operators of the Liouville field $\partial_{+}\phi$, $\partial_{-}\phi$, $e^{g\phi}$, $e^{2g\phi}$ are constructed consistently in terms of the free field. The Liouville model field theory space is found to be restricted to the sector with field momentum $P_{+}=-P_{-}$, $P_{+}> 0$ , which is a closed subspace for the Liouville theory operator algebra.Comment: 16 p, EFI-92-6

Combined effects of long-term sitting and whole-body vibration on discomfort onset for vehicle occupants

Occupants of automobiles experience discomfort after long drives, irrespective of how well designed a seat might be. Previous studies of discomfort during driving have focused either on the seat shape and materials (“static” properties), long-term discomfort (“fatigue” properties), or dynamics (“vibration” properties). These factors have previously not been considered together. This paper reports three studies with objectives to define and test a model for describing long-term discomfort from vibration. Study 1 was an independent measures laboratory trial using an automobile seat, which lasted 80 minutes; Study 2 was a repeated measures laboratory trial using a rail passenger seat, which lasted 60 minutes; Study 3 was a repeated measures field trial in a people carrier automobile, which involved 70 minutes of travelling. The findings showed that discomfort accrues with time but that more discomfort is experienced when subjects are also exposed to whole-body vibration. Exposure to whole-body vibration accelerates development of discomfort. The relationship between the reported discomfort, the vibration magnitude, and the exposure time can be described using a multifactorial linear model. It is concluded that ignoring parts of the multi-factorial model (i.e., static, dynamic, or temporal factors) will compromise understanding of discomfort in context