2,273 research outputs found
The Effect of a Flap and Ailerons on the N.A.C.A. M-6 Airfoil Section
This report contains the results obtained at the Langley Memorial Aeronautical Laboratory on an N. A. C. A. M-6 airfoil, fitted with a flap and ailerons, and tested in the variable density wind tunnel at a density of 20 atmospheres. Airfoil characteristics are given for the model up to 48 degree angle of attack with the flap set at various angles, and also with the ailerons set at similar angles. The approximate lift distribution and the center of pressure variation along the span are determined with the model at 18 degree angle of attack and with the ailerons displaced at 20 degrees. Approximate rolling moment and yawing moment coefficients are determined for the various aileron settings. A comparison of the calculated angles of zero lift and the calculated lift and moment coefficiencies with those observed is given in the appendix
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Ethical Issues in Genetic Testing for Inherited Cancer Predisposition Syndromes: the Potentially Conflicting Interests of Patients and Their Relatives
Purpose of Review
This review uses clinical cases to highlight some of the ethical dilemmas currently faced by oncologists, geneticists and others who request genetic testing for inherited cancer disorders.
Recent Findings
Recent ethical guidance supports clinicians in testing patients when other family members decline similar testing, even when such testing will reveal those family members’ genetic status. And increasingly there is acknowledgement that when a patient declines to share genetic results with family members, clinicians may have an ethical duty to breach patient confidentiality in order to inform at-risk relatives to whom they may owe a duty of care, so that they can choose to access genetic testing and potentially life-saving screening and treatment.
Summary
Genetic testing for inherited cancer disorders raises multiple ethical issues, which cannot always be easily resolved by discussion with patients, or with their family members. Clinical ethics committees can provide valuable assistance in resolving the dilemmas presented in these cases
Follow-Up Observations of PTFO 8-8695: A 3 MYr Old T-Tauri Star Hosting a Jupiter-mass Planetary Candidate
We present Spitzer 4.5\micron\ light curve observations, Keck NIRSPEC radial
velocity observations, and LCOGT optical light curve observations of
PTFO~8-8695, which may host a Jupiter-sized planet in a very short orbital
period (0.45 days). Previous work by \citet{vaneyken12} and \citet{barnes13}
predicts that the stellar rotation axis and the planetary orbital plane should
precess with a period of days. As a consequence, the observed
transits should change shape and depth, disappear, and reappear with the
precession. Our observations indicate the long-term presence of the transit
events ( years), and that the transits indeed do change depth, disappear
and reappear. The Spitzer observations and the NIRSPEC radial velocity
observations (with contemporaneous LCOGT optical light curve data) are
consistent with the predicted transit times and depths for the $M_\star = 0.34\
M_\odot$ precession model and demonstrate the disappearance of the transits. An
LCOGT optical light curve shows that the transits do reappear approximately 1
year later. The observed transits occur at the times predicted by a
straight-forward propagation of the transit ephemeris. The precession model
correctly predicts the depth and time of the Spitzer transit and the lack of a
transit at the time of the NIRSPEC radial velocity observations. However, the
precession model predicts the return of the transits approximately 1 month
later than observed by LCOGT. Overall, the data are suggestive that the
planetary interpretation of the observed transit events may indeed be correct,
but the precession model and data are currently insufficient to confirm firmly
the planetary status of PTFO~8-8695b.Comment: Accepted for publication in The Astrophysical Journa
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Microhardness and elastic modulus of nanocrystalline Al-Zr
An investigation of the mechanical properties of nanocrystalline Al-Zr alloy composites has been conducted via nanoindentation and Vickers microhardness experiments. The microhardness of the samples exhibits a four-fold increase over the concentration range of 0-30 wt.% Zr, from {approximately}0.7 GPa to nearly 3 GPa. The aluminum grain size is found to be strongly correlated with the level of zirconium present in the samples, suggesting that the observed hardness increase can be attributed to the combined effects of alloying and grain size reduction. The elastic moduli of the nanocrystalline Al-Zr samples are determined to be similar to the modulus of coarse-grained aluminum and independent of zirconium content
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Managing digital coordination of design: emerging hybrid practices in an institutionalized project setting
What happens when digital coordination practices are introduced into the institutionalized setting of an engineering project? This question is addressed through an interpretive study that examines how a shared digital model becomes used in the late design stages of a major station refurbishment project. The paper contributes by mobilizing the idea of ‘hybrid practices’ to understand the diverse patterns of activity that emerge to manage digital coordination of design. It articulates how engineering and architecture professions develop different relationships with the shared model; the design team negotiates paper-based practices across organizational boundaries; and diverse practitioners probe the potential and limitations of the digital infrastructure. While different software packages and tools have become linked together into an integrated digital infrastructure, these emerging hybrid practices contrast with the interactions anticipated in practice and policy guidance and presenting new opportunities and challenges for managing project delivery. The study has implications for researchers working in the growing field of empirical work on engineering project organizations as it shows the importance of considering, and suggests new ways to theorise, the introduction of digital coordination practices into these institutionalized settings
Evaluation of Talking Parents, Healthy Teens, a new worksite based parenting programme to promote parent-adolescent communication about sexual health: randomised controlled trial
Objective To evaluate a worksite based parenting programme—Talking Parents, Healthy Teens—designed to help parents learn to address sexual health with their adolescent children
Renormalization group and perfect operators for stochastic differential equations
We develop renormalization group methods for solving partial and stochastic
differential equations on coarse meshes. Renormalization group transformations
are used to calculate the precise effect of small scale dynamics on the
dynamics at the mesh size. The fixed point of these transformations yields a
perfect operator: an exact representation of physical observables on the mesh
scale with minimal lattice artifacts. We apply the formalism to simple
nonlinear models of critical dynamics, and show how the method leads to an
improvement in the computational performance of Monte Carlo methods.Comment: 35 pages, 16 figure
Diamagnetic Suppression of Component Magnetic Reconnection at the Magnetopause
We present particle-in-cell simulations of collisionless magnetic
reconnection in a system (like the magnetopause) with a large density asymmetry
across the current layer. In the presence of an ambient component of the
magnetic field perpendicular to the reconnection plane the gradient creates a
diamagnetic drift that advects the X-line with the electron diamagnetic
velocity. When the relative drift between the ions and electrons is of the
order the Alfven speed the large scale outflows from the X-line necessary for
fast reconnection cannot develop and the reconnection is suppressed. We discuss
how these effects vary with both the plasma beta and the shear angle of the
reconnecting field and discuss observational evidence for diamagnetic
stabilization at the magnetopause.Comment: 10 pages, 10 figures; accepted by JGR; agu2001.cls and agu.bst
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