Criminal Liability for Unlawful Actions in Bankruptcy: the Current State, Problems and Methods of Resolution

Bankruptcy is a legally justified mechanism of a market economy and must comply with modern social realities. Despite the fact that the legal field in this area is well developed, the existing problems in implementing the provisions of the insolvency institution make it vulnerable and subject it to criminalization. The article describes the main problems that the law enforcer could find and ways to solve them in the Russian Federation. The Authors propose to define the presence of signs of bankruptcy as identical to the situation in which the crimes committed under Part 1 and Part 2 of Art. 195 of the Criminal Code of the Russian Federation – “if there are signs of bankruptcy”, that is, apply a literal interpretation, guided by the provisions of Art. 3 of the Bankruptcy Law. The legislator has created conditions restricting the application of Part 3 of Art. 195 of the Criminal Code of the Russian Federation, since it established that criminal liability can only arise in cases where the functions of the head of an organization are either assigned to an arbitration manager or to the head of the provisional administration of a credit organization. To resolve this problem, we believe that the legislator needs to state Part 3 of Art. 195 of the Criminal Code of the Russian Federation as amended, which takes into account the possibility for the law enforcer to involve the guilty person at all stages of the bankruptcy procedure. When assessing major damage, arbitration prejudice should be taken into account in the first place, in order to increase the preventive potential of this article, the Authors propose an exception to the category of “major damage” with the corresponding loss of force, Parts 1,2,4 of Art. 14.12 Code of Administrative Offences of the Russian Federation. Particular attention is paid to the issues of determining the subject composition of Art. 195 of the Criminal Code of the Russian Federation. Interpretation of Part 2 of Art. 195 of the Criminal Code of the Russian Federation allows us to conclude that the subject of this crime can also be a creditor who exhibits dishonest behavior, whose property claims are illegally satisfied to the detriment of other creditors. The article also deals with the legal technique of the offense under of Art. 195 of the Criminal Code of the Russian Federation, and a number of novel recommendations are proposed for improving this norm and the norms that bind the institution of bankruptcy, as well as for their application

РАЗВИТИЕ КОНТРАСТНЫХ ПРЕПАРАТОВ ДЛЯ ДИАГНОСТИКИ ВНУТРИПРОТОКОВЫХ ЗАБОЛЕВАНИЙ МОЛОЧНОЙ ЖЕЛЕЗЫ

Breast is the organ with low natural visibility, this fact don’t let us to produce an image of milk ducts on the plain film. Assessment of the milk ducts is an important condition to identify the earliest signs of diseases like cancer and benign nature. It is known that up to 80% of the cancer develops ductal epithelium of the breast. Traditional ultrasonic scanning because of it’s inefficient resolution capability and physical peculiarities of method enables us to define only 4-5 mm intraductal tumors. Many attempts of improvement of intraductal breast deceases diagnostic were made for many years to come. Different technologies: cytological analysis, radiography, US, MRI were used for achieving these purposes. They didn’t always allow us to think definitely of one ore other process. It led to a need to improve the objective methods of visual diagnostics due to increasing contrast of objects being investigated including radiography.Молочная железа - орган, обладающий низкой естественной контрастностью, что ограничивает возможности получения изображения млечных протоков на обзорном рентгеновском снимке. Оценка состояния млечных протоков - важное условие для выявления самых ранних признаков заболеваний как злокачественной, так и доброкачественной природы. Известно, что до 80% случаев рака развивается из эпителия протоков молочной железы. Традиционное УЗИ в силу недостаточной разрешающей способности и физических особенностей метода позволяет увидеть протоковые разрастания размерами лишь от 4-5 мм. В течение многих лет предпринимались попытки улучшения диагностики внутрипротоковых заболеваний молочной железы. Для этих целей использовались различные технологии: цитологическое исследование, рентгенография, УЗИ, МРТ. Они далеко не всегда позволяли достоверно судить о том или ином процессе. Это привело к необходимости усовершенствования объективных методов визуальной диагностики за счет повышения контрастности изучаемого объекта, в том числе при рентгенографии

Evaluation of the efficiency of phytotherapy with mastodinone and gelarium in patiens withdiffuse forms of mastopathies

The authors define mastopathies and consider the major forms of this disease. They also present the results of the clinical trials evaluating the efficiency of the herbal drugs mastodinone and gelatium in different forms of diffuse mastopathies, accompanied by the pain syndrome of varying degree, and depression

A comparison of different cryoprotectant solutions and thawing methods for cryo­preservation of embryos of mice and rats

The proper choice of cryoprotectant and thawing method affects cryopreservation efficiency. A freezing-thawing method for sparing embryonic cells was evaluated in experiments with ICR mice. Cleavage-stage embryos of ICR mice, GC rats, and OXYS rats were collected on Day 3 of pregnancy and frozen in plastic straws according to a standard protocol. Permeating (ethylene glycol and glycerol) and nonpermeating (sucrose) cryoprotectants and their combinations were compared during the freezing of ICR mouse embryos. With these mice, two thawing methods were compared: rapid (water bath, 10 s, 37 °С) and slow (40 s, room temperature; 40 s, 30 °С). Embryo viability in mice and rats was evaluated by their in vitro culturing after thawing. Our data on mice indicate that slow thawing is more suitable for sparing the integrity of embryonic cells; moreover, supplementation of the main cryoprotectant (either ethylene glycol or glycerol) with sucrose is beneficial for subsequent in vitro culture, especially in the case of glycerol. This freezing-thawing protocol (with glycerol and sucrose as cryoprotectant agents and slow thawing) was applied to rats of the GC and OXYS strains; the survival rate after cryopreservation was 68–83.3 %, and the rate of in vitro development was 64.7–66.6 %

Effects of growth factors during in vitro culture of mouse and rat embryos

In vitro culture of preimplantation embryos of ICR, HT1AN/Icgn, HT1AC/Icgn and C57BL/6J-Ay mouse strains as well as in OXYS/Icgn rat strain in media containing granulocyte-macrophage colony stimulating factor (GM-CSF) or epidermal growth factor (EGF) has been studied. Both mouse and rat embryos were first frozen in a programmable freezer after a standard protocol using a mixture of glycerol and sucrose as cryoprotectants, thawed and cultured in vitro in R1ECM (rat one-cell embryo culture medium) for 24 hours (mice) and 72 hours (rats). For the in vitro culture experiments with these growth factors, 8-cell frozen-thawed mouse embryos and 2–4-cell frozen-thawed rat embryos were used. Supplementation of the culture medium with GM-CSF improved the rate of embryonic development in HT1AC/Icgn and C57BL/6J-Ay strain mice, while EGF had no effect. The reverse was true of the rats. Supplementation of the culture medium with EGF increased the percentage of deve­loping blastocysts in OXYS/Icgn rat strain, while GM-CSF had no effect. Co-culture of four-cell embryos of HT1AN/ Icgn strain mice with more advanced embryonic stages (morulas) of a different strain ICR led to the facilitation preimplantation embryo development. Experimental results presented here reveal the species-specific effects of growth factors on mouse and rat embryos and indicate that co-culture of different stages of embryo development have stimulatory effects on earlier stages

Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data

Modern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications often use the term “Syndrome of megalopolis”, which means disruption of sleeping, high anxiety, and altered reproductive function. Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. Long-lasting distress may worsen health in general and suppress reproductive function, in particular. The review presents the data on the effects of maternal stress on folliculogenesis, especially when assisted reproductive technologies (ARTs) are used. Clinical data are presented alongside data from laboratory animal experiments. Different maternal stress models are taken into account in respect of their inf luence on oocyte maturation and embryo development. The interfering of psycho-emotional stress and reproductive function is the focus of the review. In these situations, exogenous hormones compensate for the stress-related disruption of the hypothalamic-pituitary-gonadal axis. When ARTs are implemented, stress-induced disruption of oogenesis is realized not via a decrease in hypothalamic and pituitary hormones, but by other ways, which involve paracrine mechanisms described in this review. Based on the literature analysis, one may conclude that stress negatively affects oocyte maturation in the ovary and suppresses subsequent embryo development. The role of some ovarian paracrine factors, such as BDNF, GDF-9, HB-EGF, TNF-α, and some others has been elucidated

MOLECULAR MARKING OF SUNFLOWER LINES WITH DIFFERENT ABILITY TO SUPPRESSION OF THE CYTOPLASMIC MALE STERILITY PHENOTYPE

Ninety five lines of sunflower genetic collection differing by their ability to suppress the CMS phenotype were molecularly marked with the use of 7 primer pairs. Using the STS marker orfH522, a sterile (PET1) cytoplasmon was identified in 79 lines, which confirmed indirectly the presence of fertility restoration genes in their genotypes. The majority of these lines also have a complex of molecular markers linked to the Rf1 gene. The HRG01, HRG02 and STS115 markers showed the best diagnostic value in revealing the Rf1 gene in the examined material. The data on allelic variation of the microsatellite loci ORS224, ORS511 and ORS799 were obtained for the first time

Comparison of in vivo and in vitro preimplantation embryo development in OXYS and WAG rats

OXYS rats are the model of precocious senescence. Numerous studies addressed physiology and behavior in rats of this strain during a postnatal period of their life, however, preimplantation development in OXYS rats has not yet been investigated. This study is addressing preimplantation embryonic development in OXYS rats both in vivo and in vitro. Rats of the WAG strain were used as controls. For studying the in vivo development, the embryos were collected from OXYS and WAG rats on day 5 post coitum, the stages of embryo development were estimated, the percentage of embryos at blastocyst stage and the cell numbers in these blastocysts were counted. In a special experiment, for studying in vitro development, the embryos were collected from both rat strains on day 4 post coitum and were cultured in vitro in P1 medium for 48 hours with or without supplementation with IGF-1 (200 ng/mL). Thereafter the percentage of embryos at blastocyst stage and the cell numbers in these blastocysts were counted in the same manner as for the in vivo experiment. This study reports that in vivo derived blastocysts of OXYS rats contain fewer cells on day 5 of their development than in vivo derived blastocysts of WAG rats. In vitro culture of the early preimplantation embryos in P1 medium mitigated the difference in the rate of embryo development between these two strains, the addition of IGF-1 into culture medium exerts neither negative nor positive effect on the rate of in vitro embryo development in rats of both strains