INVESTIGATION OF PHENYLEPHRINE SULFATION AND INHIBITION USING A NOVEL HILIC ASSAY METHOD

Phenylephrine (PE) is the most commonly used over-the-counter nasal decongestant. The problem associated with phenylephrine is that it undergoes extensive first pass metabolism in the intestinal gut wall leading to its poor and variable oral bioavailability. This research project aims at developing strategies in order to increase the oral bioavailability of PE by co-administration of GRAS compounds. A HILIC assay method was developed to detect the parent drug, phenylephrine (PE) and its sulfate metabolite (PES).The enzyme kinetic studies were done with phenolic dietary or GRAS compounds using LS180 human intestinal cell model, recombinant SULT enzymes and human intestinal cytosol (HIC). From the screening studies done, one inhibitor was selected in order to study the mechanism of inhibition. In conclusion the studies done in vitro provided a basis in order to predict in vivo intrinsic clearance through the sulfation pathway

The influence of some anthropometric parameters on the marathon results of the world athletics championships 2019 in Doha

The research was conducted on a sample of 55 successful female marathoners who participated in ten of the most popular marathon races. The sample of subjects includes ten of the best marathoners positioned in every race held at the 2019 World Athletics Championships in Doha, Qatar. The purpose of the research is to assess the impact of body height, weight and age of marathon runners on the final result in the race.  The collected data is processed by the basic descriptive parameters. The entities have the average weight of 60.81 kg, with the average height of 171.65 cm, at the average age of 32.92, with the achieved average result of 137.86 hours into the race. In the intercorrelation matrix, only a significant correlation coefficient (p<0.001) is obtained for height and body weight. From the regression analysis the influence of the predictor variables (height, weight and age) on the criterion variable – sig.=0,60 (the result of the marathon) is not confirmed, which provides only 36% (RO²=.366) of analysis in the common ground of variability. The remaining 64% of the analysis of the total variability of the criterion variable may be attributed to other anthropological characteristics, and mainly to functional characteristics of the anaerobic type

Influence of some anthropometric, motor and bone mass parameters on short distance running

The knowledge on morphological development and their impact on motor skills in short distance athletes should be one of the main preoccupations of athletics coaches, because any scientific research in the field of physical culture and sports is concerned with proving the development and evaluation of anthropological characteristics which are responsible in achieving success in athletics.The purpose of this paper is to prove the impact of some anthropometric, motor-specific characteristics and those of bone weight in short distance running, specifically in 100 meters, with students aged 19 ± 6 years, of the Faculty of Physical Education and Sports in Pristina.The sample of this research included a total of 75 students aged 19 of the Faculty of Physical Education and Sports in Pristina.The variables which were applied in this research were 7 anthropometric variables and 6 motor variables and 1 specific motor variable.Regression analysis in the manifest space was applied to determine the relationship between predictive variables (anthropometric and motor characteristics) and criterion variable (100 m running)

Influence of some anthropometric and motor parameters on triple jump

Athletics disciplines are characterized by motor movements that can be successfully applied during the educational process or through other forms of exercise, which significantly affect the development of general psychophysical abilities of individuals. Each of the disciplines of athletics acts on the development of individual abilities, but also on the general psychophysical status of man and for this reason athletics is called the "queen of sports". Athletic activities have a characteristic of participant inclusion.The values of the paper will be based on the purpose of anthropometric, basic motor and specific motor characteristics of students aged 21 years ± 6 months.A total of 70 male students, 7 anthropometric variables, 7 motor variables and 1 specific motor variable that were tested during the period of May, of the academic year, 2020/2021 were included in the research.In the basic parameters students, based on the results achieved in this anthropometric variable, are presented as a moderately homogeneous group.Although it is seen that the acquired flexibility and convexity (Skewness and Kurtosis) have a pronounced asymmetry, in the vast majority of anthropometric variables. Although it is seen that the acquired flexibility and convexity (Skewness and Kurtosis) have a pronounced asymmetry, in the vast majority of motor and criterion variables. Thus the statistically significant coefficients of the variables with the highest degree of statistical inference (p <0.01) are denoted by two asterisks. With easier statistical conclusion criterion (p <0.05) correlation coefficients. All variables have statistically significant correlation to all anthropometric, basic and criterion motor variables

Physiological anthropometric and motor values in relation to 500 metres running

 The primary purpose of this paper is to determine and prove the impact of loads with different intensities on the treadmill on the heart frequency, as well as to prove the relationship and impact of some anthropometric and motor parameters on the physiological one in the manifest space. In harmony with the purpose of the research, three basic hypotheses have been presented that cover the anthropological research fields. In this paper, 19-year-old students of the Faculty of Sports Sciences are included. To achieve the purpose of the paper, a sample of 80 students who were regular students during the year 2022/2023 was included. Four anthropometric variables, three motor tests (running tests) and four physiological tests (pulse at rest and during loads) are included in this paper. For the three groups of the system of variables, the basic statistical and distribution parameters for each variable, as well as the measures of asymmetry and normal distribution, were calculated. Then the correlations between the variables in the manifest space, as well as the correlations between the system of variables. In order to determine the relationship between predictor variables (anthropometric and motor characteristics) and criterion variables (results of functional skills), regression analysis was applied in the manifest space. The processing of the results shows that the obtained values do not deviate from the normal distribution, which completes their metric characteristics. The impact of morphological and motor factors on heart rate results has not been proven

The Impact Of Short Run Distances To The Final Results Of The Decathlon At The 2019 Athletic World Championships

Athletic operates on the basis of a particular system of knowledge that has in its contentthe theoretical and methodological foundations of sport training (Rashiti N, Nika F, Bekolli L, Heta G.) 2017. Athletic is one of the types of sports, with complex and applicable character, consisting of large groups, which include different athletic types, with similar characteristics among them; our treatment is athletic decathlon.(Dibra F.)2006. The decathlon is a complexcombined event in athletic consisting of ten track and field events.Olympic men’s decathlons are divided into a two-day competition. The evaluation is done by points.Men’s decathlonconsists of:100m,Long jump,Shot put,High jump, 400m (Day 1); 110m hurdles,Discus throw,Pole vault,Javelin throw,1500m(Day 2).The main purpose of this paper was to verify that from the disciplines of the Decathlon:Long jump,Shot put,High jump, Discus throw,Pole vault,Javelin throw and1500m,as predictor (independent) variables will have an impact on the performance of specific motor tasks, respectively the execution of disciplines pertaining to short-distance running:100m, 110m  hurdles and 400mas well as to determine the impact of these short-distance running to the final result of the decathlon knowing that these disciplines in athletics are largely genetically determined.(Misja B.) 2012The sample for the purposes of this paper will include 10 first contestants of decathlons World Championship: September 27 and October 6, 2019 in Doha, Qatar.In this research, after obtaining a statistically significant multiple correlation (R = 0.936) it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable 400m.We can emphasize that the test (F-test) is always more valuable if the multiplex correlation is greater, in this case it is significant (Sig = 0.000), because the value of the F-test is 15,347.A statistically significant multiple correlation was obtained (R = 0.958); it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor (independent) variable in the dependent variable or criterion 110 m.In this research, after obtaining a statistically significant multiple correlation (R = 0.958), it is necessary to search for the coefficient in the (Beta) column as well as the (t-test) value indicating the influence of each predictor variable (independent) in the dependent or criterion variable) 100 m.

Es taut! Frozen-Ground Cartoons: Eine internationale Kooperation zwischen Künstlern und Permafrost-Wissenschaftlern

Dieses Projekt startete im Oktober 2015 mit einer verrückten Idee: Schreiben und Einreichen eines Antrags auf Förderung einer internationalen, multidisziplinären und nicht-traditionell wissenschaftlichen Projektinitiative… innerhalb von 48 Stunden. Und es hat geklappt ! Eine Gruppe hoch motivierter, junger Forscher aus Kanada und Europa hat sich gebildet, um Kunst und Wissenschaft zu kombinieren und eine Reihe von Comics über Permafrost (gefrorene Böden) zu produzieren. Unser Ziel ist es, zu zeigen, wie wissenschaftliches Arbeiten im hohen Norden funktioniert, mit dem Schwerpunkt auf Geländearbeit und den schnellen Umweltveränderungen in der Arktis. Die Zielgruppe sind Kinder, Jugendliche, Eltern und Lehrer, mit dem allgemeinen Ziel, Permafrost zugänglicher und mit Spaß zu vermitteln. Denn ratet mal: Permafrost ist ein Gebiet von mehr als 20 Millionen km2 auf der Nordhalbkugel – ein riesiges Gebiet. Durch die Klimaerwärmung taut der Permafrost und wird zu instabil, um Häuser, Straßen und Flughäfen zu tragen. Durch das Auftauen von gefrorenem Boden werden außerdem Pflanzen- und Tierhabitate zerstört, die Wasserqualität und Ökologie von Seen beeinflusst und auf Grund der Freisetzung von Kohlenstoff als Treibhausgas in die Atmosphäre wird der Klimawandel sogar verstärkt. Daher betrifft Permafrost und seine Reaktion auf den Klimawandel uns alle. Die Internationale Permafrost Gemeinschaft (IPA) hat das Projekt als „Action Group“ von Beginn an unterstützt und seitdem sind noch viele weitere Sponsoren dazugekommen. Und hier sind wir nun: Zwei Jahre nach der ersten Idee. Ihr seid kurz davor das zu lesen, was das Ergebnis eines ständigen Austauschs zwischen Künstlern und Wissenschaftlern ist. Zunächst hatten wir eine Ausschreibungsrunde und erhielten 49 Bewerbungen von Künstlern aus 16 Ländern. Durch ein Bewertungsverfahren wählten wir zwei Künstlerinnen aus, um an diesem Projekt zu arbeiten: Noémie Ross aus Kanada und Heta Nääs aus Finnland. Mit den Beiträgen von Wissenschaftlern erstellten Noémie und Heta fantastische Cartoons, die ein paar der Veränderungen erklären, die in Permafrost-Gebieten passieren. Zum Beispiel: wie wird die Welt der Menschen und Tiere beeinflusst und was machen Forscher, um diese Prozesse besser zu verstehen, sodass sie den Einheimischen helfen können, innovative Wege zur Anpassung zu finden

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries