Changes in Serum Haptoglobin and Group Specific Component after Orthotopic Liver Homotransplantation in Humans

In human recipients of orthotopic liver homografts with different haptoglobin (Hp) and group specific component (Gc) types than their respective donors, the donor phenotype permanently replaced that previously present. The findings prove that the liver is the sole source of Hp and Gc, and that it retains its metabolic specificity after transplantation to a new host. © 1968, SAGE Publications. All rights reserved

Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production

Antilymphocyte gamma-G globulin (ALGG) was produced from the serum of immunized horses. Modifications of the preliminary absorption techniques permitted the removal of undesirable, extraneous antibodies. With the use of a batch technique, pure gamma-G globulin could then be removed in bulk quantities. The resulting product was first confirmed to have immunosuppressive qualities in dogs and then given a clinical trial. In patients, its administration occasionally caused low-grade fever and thrombocytopenia. Pain at the injection site was not eliminated. Precipitin antibody responses have apparently been prevented in the patients but not a host response to Forssman antigens. © 1969

A Morphological and Multicolor Survey for Faint QSOs in the Groth-Westphal Strip

Quasars representative of the populous faint end of the luminosity function are frustratingly dim with m~24 at intermediate redshift; moreover groundbased surveys for such faint QSOs suffer substantial morphological contamination by compact galaxies having similar colors. In order to establish a more reliable ultrafaint QSO sample, we used the APO 3.5-m telescope to take deep groundbased U-band CCD images in fields previously imaged in V,I with WFPC2/HST. Our approach hence combines multicolor photometry with the 0.1" spatial resolution of HST, to establish a morphological and multicolor survey for QSOs extending about 2 magnitudes fainter than most extant groundbased surveys. We present results for the "Groth-Westphal Strip", in which we identify 10 high likelihood UV-excess candidates having stellar or stellar-nucleus+galaxy morphology in WFPC2. For m(606)<24.0 (roughly B<24.5) the surface density of such QSO candidates is 420 (+180,-130) per square degree, or a surface density of 290 (+160,-110) per square degree with an additional V-I cut that may further exclude compact emission line galaxies. Even pending confirming spectroscopy, the observed surface density of QSO candidates is already low enough to yield interesting comparisons: our measures agree extremely well with the predictions of several recent luminosity function models.Comment: 29 pages including 6 tables and 7 figures. As accepted for publication in The Astronomical Journal (minor revisions

Clinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts.

Clinical reactions and serologic changes after intramuscular administration of horse anti-human lymphocyte globulin (ALG) were studied in 53 human recipients of renal homografts. The ALG was used as an adjuvant immunosuppressive drug. In the usual case 47 injections were given over a 4-month period. All patients had pain, tenderness, erythema, and swelling at the injection sites. Benign systemic side effects included fever in all cases, hives in eight cases, rash in five, pruritus in five, arthralgia in three, and periorbital edema in one. Anaphylactic reactions occurred in 11 cases. These were easily treated, and there was complete recovery in every instance within 90 min. In eight of these cases the ALG administration was discontinued. Subsequent injections were given in the other three. Four of 11 patients tested had positive skin tests to ALG before therapy. Antibodies against sheep red blood cells developed during therapy in 39 of 40 patients; 10 reached titers as high as 1:128 to 1:512. Precipitin antibodies as measured with an electroimmunodiffusion technique developed in 36 of 40 patients. All three immunologic tests were of value in predicting the probability of an anaphylactic reaction, but the discrimination was imperfect Immunoelectrophoretic studies of sera from 13 patients showed antibodies to horse beta globulins in all cases, to alpha globulins in 9 cases, and to gamma globulins in only 1. This finding indicates that a safer ALG could be made by removing the trace quantities of alpha and beta globulins from the immunologically more active gamma globulins

Louis de Potter and the Belgian Revolution of 1830

Louis Joseph Antoine De Potter (1786-1.859) was the gifted journalist who served as the catalyst of the successful Belgian revolution of 1830. He has been largely overlooked by students of the nineteenth century revolutionary era. Only one of De Potter\u27s works is known to have been translated into English, his Vie de Scipion de Ricci. This paper has examined the development of De Potter\u27s thought from his youth up to and including his participation in the Provisional Belgian Government of 1830. For clarity this study has been divided into four chapters

Polymorphism of sheep MHC Class IIb gene TAPASIN

The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway. Sheep TAPASIN is located in the class IIb region of the MHC. Sheep TAPASIN was subcloned from BAC and cosmid genomic clones and DNA sequenced. TAPASIN is 9549 bp in length and encodes a protein of 447 amino acids. The structure of sheep TAPASIN was similar to other mammals and consisted of eight exons with a distinctively larger intron between exon three and four. Sheep TAPASIN gene had high sequence identity with other mammalian TAPASINs. The TAPASIN gene sequence is conserved across many mammalian species and is possibly maintained through purifying selection with the average ratio of ds/dn of 3.9. Twenty-six SNPs in sheep TAPASIN were identified

Fluid structure interaction analysis: vortex shedding induced vibrations

Abstract Fluid Structure Interaction (FSI) numerical modelling requires an efficient workflow to properly capture the physics involved. Computational Structural Mechanics (CSM) and Computation Fluid Dynamics (CFD) have to be coupled and at the moment there is a lack of monolithic solvers capable to tackle industrial applications that involves high fidelity models which mesh can be comprised of hundred millions of cells. This paper shows an efficient approach based on standard commercial tools. The FEM solver ANSYS® Mechanical™ is used to extract a given number of eigenmodes. Then the modal shapes are imported in the CFD solver Fluent® using the Add On RBF Morph™. Updating the modal coordinates it is possible to adapt the shape of the model by taking into account the elasticity of the CFD model. Transient analysis is faced using a time marching solution by updating the shape of the mesh at each time step (weak coupling, evaluated as single DOF systems and integrating modal forces over the CFD grid). Numerical performances and solution accuracy of this approach are analyzed on a practical application (NACA0009 Hydrofoil) for which experimental data are available. A comparison between proposed method and experiment is provided. Transient coupled solver is used for the computation of eigenvalues in water by post processing the free vibration response in calm fluid