"Comme une Hantise" La greve des minuers 30 ans apres

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‘Sticking together!’ Policy activism from within a UK coal-mining community

This article reflects on some aspects of a doctoral ethnographic study of young people disaffected from schooling in a post-industrial space of ruin in a former coal-mining community in England. It considers how their experiences of resistance and refusal of schooling can, in the relational ethos of non-school support settings, come to speak back to hegemonic policy, particularly around ‘aspiration’. Focusing on the example of a young people's film project, data are assembled showing how a local culture of ‘resistant aspiration’ – itself affectively linked to sedimented traditions of insubordination – forms a site of activist possibility. In this site, the ground-level resistance of the young people and the more strategically informed interventions of a group of locally originating staff come together in a moment of policy activism that displays both scope and limitation

‘The lady is not returning!’: educational precarity and a social haunting in the UK coalfields

© 2015 Taylor & Francis.Drawing on research in de-industrialised coal-mining communities in the north of England, this article focuses on how experiences of some young people might be approached through a notion of precarity linked to the idea of a ‘social haunting’ of the coalfields. Concentrating on data gathered in the period after the 2010 change of UK government, the article considers how localities suffering under the impact of ‘austerity’ measures have also witnessed moments of vivid, carnivalesque resurgence linked to celebrations of the death of former British Prime Minister Margaret Thatcher in April 2013 and of the thirtieth anniversary of the 1984–1985 UK miners’ strike during 2014–2015. These celebrations mark a watershed in the cultural and affective life of the communities, one aspect of which relates to how young people with very different educational trajectories have become involved alongside each other in those events as a result of their different experiences of precarity

‘Off The Model’: resistant spaces, school disaffection and ‘aspiration’ in a former coal-mining community

Discussions of ‘aspiration’ influencing contemporary education policy and practice are framed almost exclusively in terms of individual – or, at most, familial – ambitions towards economic prosperity. The failure to achieve ‘social mobility’ in British society is often posed as being due to the ‘low aspirations’ of working class children, particularly in formerly heavily industrialised areas. In a classic case of ‘blaming the victim’ the social exclusion that undoubtedly exists in such areas is blamed on those who suffer it. Things would be different, the argument goes, if only people aspired to ‘get on’. This paper looks at material from an intergenerational ethnographic study of some former coal-mining communities in the north of England which are often popularly characterised as insular and lacking in ambition. In contrast to this stereotype, however, the data suggests that working class teenagers growing up in the impoverished and abandoned geography of Victorian colliery model villages, rather than suffering a failure of aspiration, often angrily and powerfully aspire – but for something contrary to the dominant model. Reviewing the ethnographic data in the light of a sociological and historical literature that attests to the exceptional nature of coal-mining communities, I suggest that such exceptionality impacts on young people's dispositions towards the educational project as a whole through a complex process of cultural transmission. A historically and locally situated notion of counter aspiration – that I call, here, resistant aspiration – is evident. I propose, in conclusion, that an acknowledgement of such resistant aspiration might help understand the widespread ‘school disaffection’ of working class youngsters not only in these former coal-mining communities but also in other post-industrial settings – nationally and internationally – that are similarly characterised by contested histories

The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.

SNAREs provide energy and specificity to membrane fusion events. Fusogenic trans-SNARE complexes are assembled from glutamine-contributing SNAREs (Q-SNAREs) embedded in one membrane and an arginine-contributing SNARE (R-SNARE) embedded in the other. Regulation of membrane fusion events is crucial for intracellular trafficking. We identify the endosomal protein Varp as an R-SNARE-binding regulator of SNARE complex formation. Varp colocalizes with and binds to VAMP7, an R-SNARE that is involved in both endocytic and secretory pathways. We present the structure of the second ankyrin repeat domain of mammalian Varp in complex with the cytosolic portion of VAMP7. The VAMP7-SNARE motif is trapped between Varp and the VAMP7 longin domain, and hence Varp kinetically inhibits the ability of VAMP7 to form SNARE complexes. This inhibition will be increased when Varp can also bind to other proteins present on the same membrane as VAMP7, such as Rab32-GTP

Challenges in Designing a National Surveillance Program for Inflammatory Bowel Disease in the United States:

This review describes the history of US government funding for surveillance programs in IBD, provides current estimates of the incidence and prevalence of inflammatory bowel diseases (IBD) in the United States (US), and enumerates a number of challenges faced by current and future IBD surveillance programs. A rationale for expanding the focus of IBD surveillance beyond counts of incidence and prevalence, in order to provide a greater understanding of the burden of IBD, disease etiology and pathogenesis, is provided. Lessons learned from other countries are summarized, as well as potential resources that may be used to optimize a new form of IBD surveillance in the US. A consensus recommendation on the goals and available resources for a new model for disease surveillance are provided. This new model should focus upon “surveillance of the burden of disease,” including 1) natural history of disease and 2) outcomes and complications of the disease and/or treatments

A Practice of Concrete Utopia? Informal Youth Support and the Possibility of 'Redemptive Remembering' in a UK Coal-Mining Area

At a moment when individualised and de-historicised notions of 'aspiration', 'resilience' and 'wellbeing' are proliferating in policy discourse shaping informal youth support practice, this article argues, instead, for a critically historical focus. In reviewing material from an intergenerational ethnographic study of young people in contact with youth support teams in a former coal-mining community in Derbyshire, UK, the case is made for understanding how young working-class people's experience of education is situated within historical geographies of collectively transmitted affect. In the particular coal-mining locality considered, these classed spatialities of feeling have been shaped through traditions of political, trade union and community resistance and mutual aid established over a 200-year period and culminating in the locally bitterly divided national miners' strike of 1984-85. Beginning from an ethnographic field note, the article outlines how such insubordinate community histories - particularly those imagining a radical reconstitution of society - can be silenced when a collective psycho-social space once redolent with hope becomes a space of ruin as a result of politically orchestrated de-industrialisation. Noticing how this compounds young people's experience of marginalisation and leaves them at once adrift from the 'illegitimate' histories that are their legitimate 'heritage', and at the same time subject to the traumatic affective legacy of those same histories, a critical counter-practice in informal youth support is proposed. Drawing on Blochian readings of Freire, the article calls for a form of intergenerational 'redemptive remembering' - a practice of 'concrete utopia' - capable of recovering 'unspeakable' community histories for a collective remaking of resilience and aspiration beyond the received confines of the neoliberal imaginary

International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats:The REVEAL Study

Background: Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved. Hypothesis/Objectives: Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH). Animals: One thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH). Methods: Retrospective multicenter, longitudinal, cohort study. Cats from 21 countries were followed through medical record review and owner or referring veterinarian interviews. Data were analyzed to compare long-term outcomes, incidence, and risk for congestive heart failure (CHF), arterial thromboembolism (ATE), and cardiovascular death. Results: During the study period, CHF, ATE, or both occurred in 30.5% and cardiovascular death in 27.9% of 1008 HCM/HOCM cats. Risk assessed at 1, 5, and 10 years after study entry was 7.0%/3.5%, 19.9%/9.7%, and 23.9%/11.3% for CHF/ATE, and 6.7%, 22.8%, and 28.3% for cardiovascular death, respectively. There were no statistically significant differences between HOCM compared with HCM for cardiovascular morbidity or mortality, time from diagnosis to development of morbidity, or cardiovascular survival. Cats that developed cardiovascular morbidity had short survival (mean \ub1 standard deviation, 1.3 \ub1 1.7 years). Overall, prolonged longevity was recorded in a minority of preclinical HCM/HOCM cats with 10% reaching 9-15 years. Conclusions and Clinical Importance: Preclinical HCM/HOCM is a global health problem of cats that carries substantial risk for CHF, ATE, and cardiovascular death. This finding underscores the need to identify therapies and monitoring strategies that decrease morbidity and mortality

Star cluster catalogues for the LEGUS dwarf galaxies

We present a new Bayesian hierarchical model (BHM) named Steve for performing Type Ia supernova (SN Ia) cosmology fits. This advances previous works by including an improved treatment of Malmquist bias, accounting for additional sources of systematic uncertainty, and increasing numerical efficiency. Given light-curve fit parameters, redshifts, and host-galaxy masses, we fit Steve simultaneously for parameters describing cosmology, SN Ia populations, and systematic uncertainties. Selection effects are characterized using Monte Carlo simulations. We demonstrate its implementation by fitting realizations of SN Ia data sets where the SN Ia model closely follows that used in Steve. Next, we validate on more realistic SNANA simulations of SN Ia samples from the Dark Energy Survey and low-redshift surveys (DES Collaboration et al. 2018). These simulated data sets contain more than 60,000 SNe Ia, which we use to evaluate biases in the recovery of cosmological parameters, specifically the equation of state of dark energy, w. This is the most rigorous test of a BHM method applied to SN Ia cosmology fitting and reveals small w biases that depend on the simulated SN Ia properties, in particular the intrinsic SN Ia scatter model. This w bias is less than 0.03 on average, less than half the statistical uncertainty on w. These simulation test results are a concern for BHM cosmology fitting applications on large upcoming surveys; therefore, future development will focus on minimizing the sensitivity of Steve to the SN Ia intrinsic scatter model.AA acknowledges the support of the Swedish Research Council (Vetenskapsradet) and the Swedish National Space Board (SNSB). DAG acknowledges support by the German Aerospace Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through program 50OR1801 ‘MYSST: Mapping Young Stars in Space and Time’

Long-term Incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Background Epidemiologic knowledge regarding noncardiovascular and all‐cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence‐based healthcare guidelines. Objectives To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all‐cause mortality in AH and pHCM cats. Animals A total of 1730 client‐owned cats (722 AH, 1008 pHCM) from 21 countries. Methods Retrospective, multicenter, longitudinal, cohort study. Long‐term health data were extracted by medical record review and owner/referring veterinarian interviews. Results Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P = .48). Cancer, chronic kidney disease, and conditions characterized by chronic weight‐loss‐vomiting‐diarrhea‐anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All‐cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P < .001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P = .10), but all‐cause survival was significantly shorter in pHCM (P = .0001). Conclusions and Clinical Importance All‐cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death