45 research outputs found

    Urzhumian stage in geochemical variations

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    Geological site Cheremushka is known as key stratigraphic record of Urzhumian stage of Middle Permian (Biarmian) series. It is situated on the Volga River's right bank, near Kazan city (Russia). In present paper lithology and geochemistry of this section is analyzed by EDXRF and discussed to reveal regional facial and cyclic features of the succession formed in altered sedimentary environments. Bulk geochemistry of sediments can be used to characterize the distribution of allogenic and authigenic components. It can also be used to compare these distributions with the general evolutionary stages of Volga River's region. The sedimentary sequence at site Cheremushka is divided into nine geochemical stages and sedimentary cycles using bulk geochemistry profiles, where silica change is considered as basic. The stage (cycles) boundaries correlate with the significant lithologic boundaries. Paleoenvironmental evolution is interpreted as alteration of lagoon and terrigenous flux influenced environments in arid climate during Sulitzkian time and in humid climate during Isheevskian time. © 2006-2014 Asian Research Publishing Network (ARPN)

    Geochemical examination of the Middle-Upper Permian rocks, Volga river reference section

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    © 2006-2016 Asian Research Publishing Network (ARPN).The Middle-Upper Permian rocks, Volga river reference section, were geochemically examined by XRF analysis to reveal the Ural provenance, aridity and humidity levels, smectite-illite association as indicator of environmental change. Geochemical variations correlate with the regional lithostratigraphic scheme and cyclicity

    The integrated exploration of Raifa lake sediments and dendrochronological analysis of Raifa forestry pines

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    © 2006-2017 Asian Research Publishing Network (ARPN). All rights reserved.The article presents some results of comprehensive research on the properties of Raifa lake bottom sediments and dendrochronological study of Raifa forestry pines (Russia). A preliminary seismic acoustic investigations have been carried out, which allowed to select the sampling site (E 48 ° 43'40.6" N 55 ° 54'21.7"). The length of core sample was 32 cm. Laboratory studies of the core, including the study of the elemental composition, magneto-mineralogical and carcinologic analysis revealed the features of sedimentation mass formation

    Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

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    Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

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    Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

    Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

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    Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Urzhumian stage in geochemical variations

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    Geological site Cheremushka is known as key stratigraphic record of Urzhumian stage of Middle Permian (Biarmian) series. It is situated on the Volga River's right bank, near Kazan city (Russia). In present paper lithology and geochemistry of this section is analyzed by EDXRF and discussed to reveal regional facial and cyclic features of the succession formed in altered sedimentary environments. Bulk geochemistry of sediments can be used to characterize the distribution of allogenic and authigenic components. It can also be used to compare these distributions with the general evolutionary stages of Volga River's region. The sedimentary sequence at site Cheremushka is divided into nine geochemical stages and sedimentary cycles using bulk geochemistry profiles, where silica change is considered as basic. The stage (cycles) boundaries correlate with the significant lithologic boundaries. Paleoenvironmental evolution is interpreted as alteration of lagoon and terrigenous flux influenced environments in arid climate during Sulitzkian time and in humid climate during Isheevskian time. © 2006-2014 Asian Research Publishing Network (ARPN)

    Data On <sup>87</sup> Sr/<sup>86</sup> Sr ratio in reference section of the upper kazanian substage

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    © 2006-2018 Asian Research Publishing Network (ARPN). In the present paper 87 Sr/ 86 Sr ratio values have been presented for the Upper Kazanian regional stratotype section - Pechishchi. The section Pechishchi is unique section formed within the Kazanian palaeosea. The position of received local data on global Phanerozoic evolution 87 Sr/ 86 Sr curve, in common, is satisfactory. Chemostratigraphic points of the Upper Kazanian substage were determined as 87 Sr/ 86 Sr values in decreasing trend up the section to the value 0,70727 in top bed 30 dated ~268,5 Ma by the Phanerozoic evolution 87 Sr/ 86 Sr curve
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