Communication Satellite Output Devices

Solid state and vacuum tube output devices for communication satellite

Current Knowledge and Attitudes Concerning Cost-Effectiveness in Glaucoma Pharmacotherapy: A Glaucoma Specialists Focus Group Study.

Background:Rising healthcare costs motivate continued cost-reduction efforts. To help lower costs associated with open-angle glaucoma (OAG), a prevalent, progressive disease with substantial direct and indirect costs, clinicians need to understand the cost-effectiveness of intraocular pressure (IOP)-lowering pharmacotherapies. There is little published information on clinicians' knowledge and attitudes about cost-effectiveness in glaucoma treatment. Purpose:This pilot focus group study aimed to explore clinician attitudes and perspectives around the costs and cost drivers of glaucoma therapy; the implementation of cost-effectiveness decisions; the clinical utility of cost-effectiveness studies; and the cost-effectiveness of available treatments. Methods:Six US glaucoma specialists participated in two separate teleconferencing sessions (three participants each), managed by an independent, skilled moderator (also a glaucoma specialist) using a discussion guide. Participants reviewed recent publications (n=25) on health economics outcomes research in glaucoma prior to the sessions. Results:Participants demonstrated a clear understanding of the economic burden of glaucoma therapy and identified medications, diagnostics, office visits, and treatment changes as key cost drivers. They considered cost-effectiveness an appropriate component of treatment decision-making but identified the need for additional data to inform these decisions. Participants indicated that there were only a few recent studies on health economics outcomes in glaucoma which evaluate parameters important to patient care, such as quality of life and medication adherence, and that longitudinal data were scant. In addition to efficacy, participants felt patient adherence and side-effect profile should be included in economic evaluations of glaucoma pharmacotherapy. Recently approved medications were evaluated in this context. Conclusion:Clinicians deem treatment decisions based on cost-effectiveness data as clinically appropriate. Newer IOP-lowering therapies with potentially greater efficacy and favorable side-effect and adherence profiles may help optimize cost-effectiveness. Future studies should include: clinicians' perspectives; lack of commercial bias; analysis of long-term outcomes/costs; more comprehensive parameters; real-world (including quality-of-life) data; and a robust Markov model

Optical investigations of noncrystalline semiconductors

Three areas of investigation into the properties of amorphous silicon and boron are reported: (1) optical properties of elemental amorphous semiconductors; (2) Mossbauer studies of disordered systems; and (3) theoretical aspects of disordered semiconductors

MeV ion scattering from thin Si single crystals: A novel approach to interface studies

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Remote sensing of tropical tropopause layer radiation balance using A-train measurements

Determining the level of zero net radiative heating (LZH) is critical to understanding parcel trajectory in the Tropical Tropopause Layer (TTL) and associated stratospheric hydration processes. Previous studies of the TTL radiative balance have focused on using radiosonde data, but remote sensing measurements from polar-orbiting satellites may provide the relevant horizontal and vertical information for assessing TTL solar heating and infrared cooling rates, especially across the Pacific Ocean. CloudSat provides a considerable amount of vertical information about the distribution of cloud properties relevant to heating rate analysis. The ability of CloudSat measurements and ancillary information to constrain LZH is explored. We employ formal error propagation analysis for derived heating rate uncertainty given the CloudSat cloud property retrieval algorithms. Estimation of the LZH to within approximately 0.5 to 1 km is achievable with CloudSat, but it has a low-altitude bias because the radar is unable to detect thin cirrus. This can be remedied with the proper utilization of Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) lidar backscatter information. By utilizing an orbital simulation with the GISS data set, we explore the representativeness of non-cross-track scanning active sounders in terms of describing the LZH distribution. In order to supplement CloudSat, we explore the ability of Atmospheric Infrared Sounder (AIRS) and Advanced Microwave Scanning Radiometer-EOS (AMSR-E) to constrain LZH and find that these passive sounders are useful where the cloud top height does not exceed 7 km. The spatiotemporal distributions of LZH derived from CloudSat and CALIPSO measurements are presented which suggest that thin cirrus have a limited effect on LZH mean values but affect LZH variability

Elemental surface analysis at ambient pressure by electron-induced x-ray fluorescence

The development of a portable surface elemental analysis tool, based on the excitation of characteristic x rays from samples at ambient pressure with a focused electron beam is described. This instrument relies on the use of a thin electron transmissive membrane to isolate the vacuum of the electron source from the ambient atmosphere. The major attributes of this instrument include rapid (several minutes) spectrum acquisition, nondestructive evaluation of elemental composition, no sample preparation, and high-to-medium (several hundreds µm) spatial resolution. The instrument proof-of-principle has been demonstrated in a laboratory setup by obtaining energy dispersive x-ray spectra from metal and mineral samples

Reconnecting Magnetic Flux Tubes as a Source of In Situ Acceleration in Extragalactic Radio Sources

Many extended extragalactic radio sources require a local {\it in situ\/} acceleration mechanism for electrons, in part because the synchrotron lifetimes are shorter than the bulk travel time across the emitting regions. If the magnetic field in these sources is localized in flux tubes, reconnection may occur between regions of plasma \be (ratio of particle to magnetic pressure) $<<1$, even though $\beta$ averaged over the plasma volume may be \gsim 1. Reconnection in low $\beta$ regions is most favorable to acceleration from reconnection shocks. The reconnection X-point regions may provide the injection electrons for their subsequent non-thermal shock acceleration to distributions reasonably consistent with observed spectra. Flux tube reconnection might therefore be able to provide $in\ situ$ acceleration required by large scale jets and lobes.Comment: 14 pages, plain TeX, accepted to Ap.J.Let

What Is The Neon Abundance Of The Sun?

We have evolved a series of thirteen complete solar models that utilize different assumed heavy element compositions. Models that are based upon the heavy element abundances recently determined by Asplund, Grevesse, and Sauval (2005) are inconsistent with helioseismological measurements. However, models in which the neon abundance is increased by 0.4-0.5 dex to log N(Ne) = 8.29 +- 0.05 (on the scale in which log N(H) = 12) are consistent with the helioseismological measurements even though the other heavy element abundances are in agreement with the determinations of Asplund et al. (2005). These results sharpen and strengthen an earlier study by Antia and Basu (2005). The predicted solar neutrino fluxes are affected by the uncertainties in the composition by less than their 1sigma theoretical uncertainties.Comment: Accepted for publication by ApJ. Minor editorial change