Role Adaptole in Correction Neurasthenia at Patients with the Syndrome of Angry Intestines (IBS)

Purpose: Estimation of clinical efficiency adaptole а in correction of an asthenic syndrome at patients with a syndrome of angry intestines (IBS).Materials and Methods: 52 patients (38 women and 14 men) with a syndrome of angry intestines (IBS) with presence of various psychopathological frustration of the neurotic register have been included in research. The age of patients varied from 28 till 40 years. Patients received a preparation adaptole in a dose 0, 5 г 2 times a day irrespective of food intake. Course of treatment 1 month. Appointment of accompanying psychotropic preparations was not supposed. The diagnosis is verified by modern clinic-tool methods of research. The psychometric research was conducted.Results: The analysis of biographical particulars has shown, that patients had expressed disturbing frustration. In group of patients with constipation variant IBS high level personal was observed and an average level of situational, that correlates with results of uneasiness on scale Sheehan, the test of color elections Lusher. Clinically authentic infringements of nervous vegetative system are found out in patients with IBS. By the end of a 3-week course of application adaptole а practically has completely disappeared somatization alarm displays, painful sensations and clinical symptoms somatovegetative were stopped to dysfunction, dissomnitice frustration, antivitale experiences. In the course of carrying out of clinical research insignificant by-effects of therapy have been found out.Summary: Аdoptole renders moderated tranquilizing influence and practically does not cause by-effects. The preparation can have metabolic an effect, normalising the various metabolic processes broken by stress, besides, аdoptole can influence functioning neurosensitive systems

Essential Phospholipids in the Treatment of the Metabolic Syndrome

Purpose: to prove the appointment of essential phospholipids in the metabolic syndrome. 1 molecule of phospholipid dissolves the 3 molecules of cholesterol and removes it from the body. Moreover, phospholipids are able to extract cholesterol from atherosclerotic plaques and cell membranes. In combination with high-density lipoprotein cholesterol phospholipids are removed from the plaques by 50% more cholesterol than without phospholipids. Phospholipids and cholesterol is carried out «maintenance» of cell membranes. Cholesterol is transported to a place of repair only as a complex with molecules of phospholipids. Thus, phospholipids are have not only the hepatoprotective, but lowering cholesterol action, which makes their assignment reasonable in patients with metabolic syndrome

Place Ursodeoxycholic Acid in Modern Hepatology

Purpose: To prove the efficacy of Ursodeoxycholic acid Urdoksa as hepatoprotector in patients with cardiac fibrosis of the liver.Materials and Methods: We examined 30 patients before and after a month’s course of therapy with 500 mg per day.Results: All patients had statistically significant positive clinical dynamics in the form of reducing of the intensity of pain in the right upper quadrant, symptoms of dyspepsia, flatulence. Itching decreased or stopped in all patients, celebrating its pretreatment. There was not adverse events in any case. On biochemical parameters observed decrease ALT levels by an average of 32%, AST by 24%, total bilirubin level decreased by 54%.Summary: Our studies confirm the high clinical efficacy, good tolerability Urdoksa and quality of life in patients with cardiac fibrosis of the liver, which allows him to recommend this group of patients

Anthropometric and functional characteristics of athletes involved in combat sports in the Greco-Roman style

Objective: to determine the morphological and functional parameters of athletes-junior wrestlers, determining their specialization, qualification and training in ontogenesis. Materials and methods: 49 male junior athletes of the school of Olympic reserve engaged in martial arts in the GrecoRoman style for 6-10 years were examined. We used the Dorokhov R.N. (1994) technique of selection and early orientation in sports to determine the anthropometric temporal characteristics. Following functional indicators were determined: absolute and relative physical performance, aerobic performance, power index eagerly, type of vegetative regulation. Results: the majority of fighters teenagers CMS had mesosomal, microcorpulent, micromesomelic, micromesic and mesomacromembral somatotype. A comprehensive study of the functional parameters of the wrestlers showed that indicators of absolute and relative physical performance were higher in young men CMS and were respectively 1318.6±149.5 kg∙m/min and 19.3±2.5 kg∙m/(min∙kg). Aerobic performance was higher in adolescents and first-rank sportsmen: 51.8±9.36 ml/(min∙kg). The strength indices of the hands were higher in the young men's CMS and contributed to 70.6±6.37% for the right hand and 66.08±12.1% for the left hand, which was explained by the component body composition of the body of young men. Most of the wrestlers revealed moderate parasympathicotonia and amphotonic. Conclusions: the R.N. Dorokhova and V.G. Petrukhina (1994) method of somatotyping allows to differentiate athletes, involved in martial arts in the Greco-Roman style, into 3 levels of variation: dimensional, component and proportion and to determine their specialization, qualification and degree of training in ontogenesis

The fate of the scientist as a reflection of the epoch: in memory of the first rector of the Kuban State Medical University Nikolai F. Melnikov-Razvedenkov

The paper analyzes the life and professional journey of Nikolai F. Melnikov-Razvedenkov, an outstanding scientist, doctor, and professor, as a reflection of Russian history from the end of the 19th century till the first quarter of the 20th century. The study identifies the role of Nikolai F. Melnikov-Razvedenkov in the development of medical science and the establishment of medical education in the Kuban region. The analysis was conducted with the involvement of archival records, personal correspondence, and scientific works of Nikolai F. Melnikov-Razvedenkov. To solve research problems, the authors used historical descriptive, comparative historical, problem-based chronological, biographical methods, and the method of monographic description. It is shown that the scientist’s fate mirrors the cultural and historical era experienced by the country. The authors define the exclusive role of Nikolai F. Melnikov-Razvedenkov in the establishment of the Kuban Medical Institute. His life path helped reveal the inviolability of medical ethics based on mercy, dedication to the profession, and willingness to serve people. Even in the situation of social upheaval Nikolai F. Melnikov-Razvedenkov found the meaning of his life in scientific work and helping people. His example will allow the modern generation of doctors to gain a greater understanding of the essential purpose of their work

Functional activity of blood eosinophils in patients with <i>Opisthorchis felineus</i> invasion

Aim. To study the functional activity of blood eosinophils in patients with Opisthorchis felineus (O. felineus) invasion.Material and methods. A total of 328 patients with O. felineus invasion (120 men and 208 women, mean age 40.3 years) and 34 practically healthy patients (14 men and 20 women, mean age 41.1 years) aged 18 to 70 years were examined. The main method for diagnosing opisthorchiasis was the determination of eggs or bodies of adult parasites in the duodenal contents and/or feces, which was used in all 328 patients with opisthorchiasis. All patients underwent a complete blood count and biochemical blood test, esophagogastroduodenoscopy and ultrasound examination of the abdominal organs. The study of the functional activity of blood eosinophils was carried out in 42 patients with opisthorchiasis and 34 healthy individuals from the control group by chemiluminescent analysis with the measurement of the intensity of production of reactive oxygen species in spontaneous and zymosan-induced reactions in lucigenin- and luminol-dependent processes.Results. The frequency of eosinophils in the complete blood count above 5% in the examined patients with opisthorchiasis was 19.5%. An increase in the content of eosinophils in the blood in patients with opisthorchiasis was associated with an increase in the frequency of complaints of pain in the right hypochondrium, pruritus, skin rashes, an increase in the proportion of leukopenia and neutropenia, an increase in the level of gamma-glutamyl transpeptidase in the blood, and an increase in the frequency of ultrasound signs of cholecystitis. At the same time, a pronounced increase in the functional activity of blood eosinophils, determined by the chemiluminescent method, was observed in patients with O. felineus invasion.Conclusions. Patients with O. felineus invasion with an increase in the content of eosinophils in the blood due to the likelihood of an aggressive course of the pathology deserve the close attention of practitioners with the need for a thorough comprehensive examination of patients, including immunological methods

Clinic-epidemiological features and principles of modern tick-borne encephalitis treatment in Zabaikaiskiy region

Analysis of 22 case histories of patients with tick-borne encephalitis in the acute period between the ages of 15 and 76 years who were in inpatient treatment showed that the average age of the patients was 36+11,6. Men prevailed among patients. Febrile variant of non-focal form of the disease prevails among hospitalized patients. We studied the dynamics of clinical symptoms and hematological parameters in patients with the febrile and meningeal form of the disease who received combined etiotropic therapy with antiviral tick immunoglobulin and «Panavir». The use of «Panavir» in complex therapy reduced the duration of clinical manifestations in the case of febrile and meningial disease.Анализ 22 истории болезни пациентов с клещевым энцефалитом в остром периоде в возрасте от 15 до 76 лет, находившихся на стационарном лечении, показал, что средний возраст заболевших - 36+11,6. Среди пациентов преобладали лица мужского пола. Среди госпитализированных преобладает лихорадочный вариант неочаговой формы заболевания. Изучалась динамика клинических симптомов, гематологических показателей у пациентов с лихорадочной и менингиальной формой заболевания, получавших комбинированную этиотропную терапию противовирусным клещевым иммуноглобулином и препаратом «Панавир». Применение препарата «Панавир» в комплексной терапии уменьшило продолжительность клинических проявлений и при лихорадочной, и при менингиальной форме заболевания

Assessment of knowledge of physicians about pharmacovigilance system

The analysis of the results of a survey of physicians of various specialties, currently working in public health practice. Installed high level of interest of physicians on the safety of pharmacotherapy. According to physicians, the low level of registration information about detected adverse reactions associated with the lack of time, lack of knowledge about the direction information. Some physicians feel a fear from administrative measures. The results indicate the need to increase the quantity of educational programs among physicians about pharmacovigilance.Проведен анализ результатов анкетирования врачей различных специальностей, работающих в настоящее время в практическом здравоохранении. Установлен высокий уровень заинтересованности врачей по вопросам безопасности фармакотерапии. Низкий уровень регистрации сведений о выявленных нежелательных реакциях связан, по мнению врачей, с нехваткой времени, незнанием порядка направления информации. Часть врачей испытывает боязнь административных мер. Полученные результаты свидетельствуют о необходимости усиления проведения образовательных программ среди врачей по вопросам фармаконадзора