Exposure to antibiotics and neurodevelopmental disorders: could probiotics modulate the gut–brain axis?

In order to develop properly, the brain requires the intricate interconnection of genetic factors and pre-and postnatal environmental events. The gut–brain axis has recently raised considerable interest for its involvement in regulating the development and functioning of the brain. Consequently, alterations in the gut microbiota composition, due to antibiotic administration, could favor the onset of neurodevelopmental disorders. Literature data suggest that the modulation of gut microbiota is often altered in individuals affected by neurodevelopmental disorders. It has been shown in animal studies that metabolites released by an imbalanced gut–brain axis, leads to alterations in brain function and deficits in social behavior. Here, we report the potential effects of antibiotic administration, before and after birth, in relation to the risk of developing neurodevelopmental disorders. We also review the potential role of probiotics in treating gastrointestinal disorders associated with gut dysbiosis after antibiotic administration, and their possible effect in ameliorating neurodevelopmental disorder symptoms

Symbolic verification of event–condition–action rules in intelligent environments

In this paper we show how state-of-the art SMT-based techniques for software verification can be employed in the verification of event–condition–action rules in intelligent environments. Moreover, we exploit the specific features of intelligent environments to optimise the verification process. We compare our approach with previous work in a detailed evaluation section, showing how it improves both performance and expressivity of the language for event–condition–action rules

Suspended Multifunctional Nanocellulose as Additive for Mortars

Cellulose derivatives have found significant applications in composite materials, mainly because of the increased mechanical performance they ensure. When added to cement-based materials, either in the form of nanocrystals, nanofibrils or micro/nanofibers, cellulose acts on the mixture with fresh and hardened properties, affecting rheology, shrinkage, hydration, and the resulting mechanical properties, microstructure, and durability. Commercial cotton wool was selected as starting material to produce multifunctional nanocelluloses to test as additives for mortars. Cotton wool was oxidized to oxidized nanocellulose (ONC), a charged nanocellulose capable of electrostatic interaction, merging cellulose and nanoparticles properties. Oxidized nanocellulose (ONC) was further functionalized by a radical-based mechanism with glycidyl methacrylate (GMA) and with a mixture of GMA and the crosslinking agent ethylene glycol dimethacrylate (EGDMA) affording ONC-GMA and ONC-GMA-EGDMA, both multifunctional-charged nanocellulose merging cellulose and bound acrylates properties. In this work, only ONC was found to be properly suitable for suspension and addition to a commercial mortar to assess the variation in mechanical properties and water-mortar interactions as a consequence of the modified microstructure obtained. The addition of oxidized nanocellulose caused an alteration of mortar porosity, with a decreased percentage of porosity and pore size distribution shifted towards smaller pores, with a consequent increase in compressive resistance, decrease in water absorption coefficient, and increased percentage of micropores present in the material, indicating a potential improvement in mortar durability

Improvement of continuous-variable quantum key distribution systems by using optical preamplifiers

Continuous-variable quantum key distribution protocols, based on Gaussian modulation of the quadratures of coherent states, have been implemented in recent experiments. A present limitation of such systems is the finite efficiency of the detectors, which can in principle be compensated for by the use of classical optical preamplifiers. Here we study this possibility in detail, by deriving the modified secret key generation rates when an optical parametric amplifier is placed at the output of the quantum channel. After presenting a general set of security proofs, we show that the use of preamplifiers does compensate for all the imperfections of the detectors when the amplifier is optimal in terms of gain and noise. Imperfect amplifiers can also enhance the system performance, under conditions which are generally satisfied in practice.Comment: 11 pages, 7 figures, submitted to J. Phys. B (special issue on Few Atoms Optics

Dyslexia Profiles Across Orthographies Differing in Transparency: An Evaluation of Theoretical Predictions Contrasting English and Greek

We examined the manifestation of dyslexia in a cross-linguistic study contrasting English and Greek children with dyslexia compared to chronological age and reading-level control groups on reading accuracy and fluency, phonological awareness, short-term memory, rapid naming, orthographic choice, and spelling. Materials were carefully matched across languages in item properties and structure. English children with dyslexia were more impaired on reading accuracy and phoneme deletion but not on reading fluency, memory, naming, or orthographic choice. No differences in impairment were observed between words and pseudowords across languages. Orthographic tests targeted specific morphemes to examine the accessibility of functionally distinct word parts across languages. There were no differences in prefix and stem orthographic choice, but English children were less successful in spelling inflectional suffixes despite greater morphological richness in Greek, highlighting the need for additional considerations beyond grain size in cross-linguistic work

Transcriptional regulation of endothelin-1 expression by advanced glycation end-products in human aortic endothelium is mediated via NF-kappaΒ and AP-1

Advanced Glycation End-products (AGEs) are produced by the non-enzymatic glycation of proteins, lipids and nucleic acids, resulting in an overload of highly reactive molecules of endogenous or exogenous (dietary) origin. Increased AGE levels in circulation and concomitant elevated tissue deposition have been associated with diabetic complications, atheromatosis, ageing and more recently with polycystic ovary syndrome pathogenesis. Interaction of AGEs with their receptor RAGE (Receptor for AGEs) activates intracellular signaling pathways which induce targeted gene expression in endothelium including upregulation of cell adhesion molecules and endothelin-1 (ET-1), implicated in vascular injury and endothelial dysfunction. The purpose of this study is to explore the molecular mechanism of AGE-induced regulation of ET-1 gene/protein expression in human endothelial cells and investigate its functional relevance in normal rat vascular endothelium

Topological optimization of quantum key distribution networks

A Quantum Key Distribution (QKD) network is an infrastructure that allows the realization of the key distribution cryptographic primitive over long distances and at high rates with information-theoretic security. In this work, we consider QKD networks based on trusted repeaters from a topology viewpoint, and present a set of analytical models that can be used to optimize the spatial distribution of QKD devices and nodes in specific network configurations in order to guarantee a certain level of service to network users, at a minimum cost. We give details on new methods and original results regarding such cost minimization arguments applied to QKD networks. These results are likely to become of high importance when the deployment of QKD networks will be addressed by future quantum telecommunication operators. They will therefore have a strong impact on the design and requirements of the next generation of QKD devices.Comment: 25 pages, 4 figure