51 research outputs found
Formation of 24Mg* in the Splitting of 28Si Nuclei by 1-GeV Protons
The 28Si(p, p' gamma)24Mg reaction has been studied at the ITEP accelerator
by the hadron-gamma coincidence method for a proton energy of 1 GeV. Two
reaction products are detected: a 1368.6-keV gamma-ray photon accompanying the
transition of the 24Mg* nucleus from the first excited state to the ground
state and a proton p' whose momentum is measured in a magnetic spectrometer.
The measured distribution in the energy lost by the proton in interaction is
attributed to five processes: the direct knockout of a nuclear alpha cluster,
the knockout of four nucleons with a total charge number of 2, the formation of
the DeltaSi isobaric nucleus, the formation of the Delta isobar in the
interaction of the incident proton with a nuclear nucleon, and the production
of a pi meson, which is at rest in the nuclear reference frame. The last
process likely corresponds to the reaction of the formation of a deeply bound
pion state in the 28P nucleus. Such states were previously observed only on
heavy nuclei. The cross sections for the listed processes have been estimated.Comment: 14 pages, 3 figures submitted to JETP Letter
Transcriptional Shift Identifies a Set of Genes Driving Breast Cancer Chemoresistance
Background
Distant recurrences after antineoplastic treatment remain a serious problem for breast cancer clinical management, which threats patients’ life. Systemic therapy is administered to eradicate cancer cells from the organism, both at the site of the primary tumor and at any other potential location. Despite this intervention, a significant proportion of breast cancer patients relapse even many years after their primary tumor has been successfully treated according to current clinical standards, evidencing the existence of a chemoresistant cell subpopulation originating from the primary tumor.Methods/Findings
To identify key molecules and signaling pathways which drive breast cancer chemoresistance we performed gene expression analysis before and after anthracycline and taxane-based chemotherapy and compared the results between different histopathological response groups (good-, mid- and bad-response), established according to the Miller & Payne grading system. Two cohorts of 33 and 73 breast cancer patients receiving neoadjuvant chemotherapy were recruited for whole-genome expression analysis and validation assay, respectively. Identified genes were subjected to a bioinformatic analysis in order to ascertain the molecular function of the proteins they encode and the signaling in which they participate. High throughput technologies identified 65 gene sequences which were over-expressed in all groups (P ≤ 0·05 Bonferroni test). Notably we found that, after chemotherapy, a significant proportion of these genes were over-expressed in the good responders group, making their tumors indistinguishable from those of the bad responders in their expression profile (P ≤ 0.05 Benjamini-Hochgerg`s method).Conclusions
These data identify a set of key molecular pathways selectively up-regulated in post-chemotherapy cancer cells, which may become appropriate targets for the development of future directed therapies against breast cancer.Thanks are due to the ConsejerĂa de Economia, InnovaciĂłn y Ciencia (CEIC) from the Junta de AndalucĂa and Fondo Europeo de Desarrollo Regional (FEDER)/Fondo de CohesiĂłn Europeo (FSE) to financial support through the Programa Operativo FEDER/FSE de AndalucĂa 2007-2013 and the research project CTS-5350. The authors also acknowledge financial support by the PN de I+D+i 2006-2009/ISCIII/Ministerio de Sanidad, Servicios Sociales e Igualdad (Spain) and Fondo Europeo de Desarrollo Regional (FEDER) from the European Union, through the research project PI06/90388
Tensor polarization of 6Li(2.186 MeV, 3+) states produced in the reaction 9Be(p, α)6Li* at 40 MeV
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