Synthesis of chiral ferrocenylazines. Negishi cross-coupling or S N H reactions?

Preparation of new hetaryl-containing planar chiral ferrocene by a nucleophilic substitution of hydrogen in azines was performed using a lithium derivative of (S)-ferrocenyl-p-tolylsulfoxide as s nucleophilic reagent © 2013 Pleiades Publishing, Ltd

5-Thienyl-2-Cycloalkylamino-1,3,4-Thiadiazines, Hydrobromides

This research was financially supported by the Ministry of Education of the Russian Federation (Project № 4.6351.2017/8.9)

On the hierarchy of partially invariant submodels of differential equations

It is noticed, that partially invariant solution (PIS) of differential equations in many cases can be represented as an invariant reduction of some PIS of the higher rank. This introduce a hierarchic structure in the set of all PISs of a given system of differential equations. By using this structure one can significantly decrease an amount of calculations required in enumeration of all PISs for a given system of partially differential equations. An equivalence of the two-step and the direct ways of construction of PISs is proved. In this framework the complete classification of regular partially invariant solutions of ideal MHD equations is given

Stable σh-adducts in the reactions of the acridinium cation with heterocyclic N-nucleophiles

A reaction of NH-heterocycles with the 10-methylacridinium cation in the presence of a base led to 9,10-dihydro-10-methyl-9-substituted acridines, which can be considered as stable intermediates in the aromatic nucleophilic substitution reaction of hydrogen. The structure of the intermediates was studied and their oxidation potentials were determined. Generally, the oxidation potential was found to symbatically change with the changes in the energy of HOMO. © 2013 Springer Science+Business Media New York

ТОЛЕРАНТНОСТЬ В КУЛЬТУРЕ ОБРАЗОВАНИЯ

The article builds the new model of tolerance in the culture of education according to the principles of free study. This model is based on the applied philosophy of Hessen. The culture of education assumes the individual cultural space of each person. The tolerance significance is revealed by means of Chupakhin’s meaning-making algorithm and Pavlova’s Vista culture needs and possibilities. The tolerance is based on the UNESCO Declaration and the preamble of the UN Charter. The authors define the axiomatic borders of tolerance by means of the ontology-based features of life mode, gnoseology and anthropological research methods of human origin. The paper estimates the significance of tolerance in educational culture within social, conceptual, spiritual and valuable parts of the human requirements. The tolerance potential is the key ethical principle of civil society that prevents from violence. Otherwise, tolerance does not belong to the culture when the anger condonation and invasion to the freedom and human merits are observed. The authors regard the meaning of perfect tolerance as the activity of moral, socio-political, ethno-cultural, economic and technological development of world society that has features of law, stability, freedom and patience. The Federal State Educational Standards of higher education highlight the following general cultural competencies of tolerant personality: the social culture implies adoption and conformation to the social laws and social mobility of the subject; the conceptual culture implies cognition process in grasping new knowledge and skills; the moral culture assumes cognition and preservation of moral values, self-identification of the subject’s consciousness and the adaptation in new environment; the According to the federal educational standards of higher education identified by the following general cultural competences formation of tolerant personality: social culture - the adoption and adherence to the laws of society, social mobility entity ; in conceptual culture - cognitive processes in general educational enrichment of new knowledge and skills; in spiritual culture - the knowledge and preservation of cultural values, self-identification and self-awareness of the subject of adaptation in the new social environment; the cultural items are the material support of a subject, foundation and usage of general material benefits included into the cultural competencies.В статье в соответствии с педагогической концепцией как прикладной философией С. И. Гессена на принципах свободы обучения осуществлено построение новой модели толерантности в культуре образования. Культура образования как процесс есть пространство построения индивидуального культурного мира каждого отдельного человека. Смысл толерантности раскрывается с помощью алгоритма смыслообразования Н. П. Чупахина в области знания в обобщенном пространстве Vista культуры потребностей и возможностей В. Д. Павловой. Аксиоматической основой толерантности являются Декларация ЮНЕСКО и Преамбула Устава ООН. С помощью онтологических особенностей быта, гносеологических законов теории познания, антропологических методов исследования происхождения и развития человека определяются аксиоматические пределы толерантности в целом, а в рамках социальной, понятийной, духовной и материальной составляющих культуры потребностей и возможностей находится смысл толерантности в культуре образования. Потенциал толерантности, актуализированный объектом культуры образования, является ключевым нравственным принципом гражданского общества, закрывающим путь произволу и насилию. В противном случае при попустительстве злу и посягательствам на свободу и нравственное достоинство человека толерантность не является признаком этой культуры. Высшим смыслом совершенной толерантности можно определить лишь созидательный путь духовно-нравственного, социально-политического, этнокультурного, экономического и научно-технического развития мирового общества, которое обладает гармоничным сочетанием законности, прочности, свободы и терпимости. Согласно федеральным образовательным стандартам высшего профессионального образования выделены следующие общекультурные компетенции формирования толерантной личности: в социальной культуре - принятие и следование законам социума, социальная мобильность субъекта; в понятийной культуре - когнитивные процессы в обогащении общеобразовательными новыми знаниями и способностями; в духовной культуре - познание и сохранение духовных ценностей, самоидентификация самосознания субъекта и адаптация в условиях новой социальной среды; в материальной культуре - материальное обеспечение субъекта, создание и использование общедоступных материальных благ, входящих в понятие всех культурных компетенций

Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc

Transition metal-free regioselective cross-coupling of azine N-oxides with cymantrenyl lithium

The facile C–C coupling reaction of activated forms of azaaromatics (azine-N-oxides) with cymantrenyl lithium, as a nucleophile, has first been carried out. It has been established that aromatization of intermediate adducts can be realized through either oxidative or eliminative pathways, depending on the structure of the starting azine N-oxide. In particular, the dihydroazinyl intermediates, bearing the additional N(4)-atom relative to the N-oxide group, proved to undergo aromatization through the eliminative pathway. The X-ray studies of 3,6-diphenyl-1,2,4-triazine-5-yl-cymantrene have revealed that it is crystallized in both orthorhombic and monoclinic forms. © 2018 Elsevier B.V

A rational protocol for the synthesis of 1-(2-pyridyl)isoquinolines

Aza-Diels-Alder reaction between 3-(2-pyridyl)-1,2,4-triazines and 1-morpholinocyclohexene followed by aromatization of the cyclohexene moiety affords 1-(2-pyridyl)isoquinolines. Crystal structures of two tetrahydroisoquinolines were confirmed by X-ray diffraction analysis. © 2013 Mendeleev Communications. All rights reserved

Pharmacologic Evaluation of Antidepressant Activity and Synthesis of 2-Morpholino-5-phenyl-6H-1,3,4-thiadiazine Hydrobromide

Substituted thiadiazines exert a reliable therapeutic effect in treating stress, and a schematic description of their ability to influence all aspects of a stress response has been depicted. This study was conducted to pharmacologically evaluate compound L-17, a substituted thiadiazine, (2-morpholino-5-phenyl-6H-1,3,4-thiadiazine, hydrobromide) for possible anti-psychotic/antidepressant activity. Compound L-17 was synthesized by cyclocondensation of α-bromoacetophenone with the original morpholine-4-carbothionic acid hydrazide. Pharmacologic evaluations were conducted using methods described by E.F. Lavretskaya (1985), and in accordance with published guidelines for studying drugs for neuroleptic activity. Compound L-17 was evaluated for various possible mechanisms of action, including its effects on cholinergic system agonists/antagonists, dopaminergic neurotransmission, the adrenergic system, and 5-HT3 serotonin receptors. One or more of these mechanisms may be responsible for the beneficial effects shown by thiadiazine compounds in experiments conducted to evaluate their activity in models of acute stress and acute myocardial infarction

Dibenzo[ f,h]furazano[3,4- b]quinoxalines: Synthesis by Intramolecular Cyclization through Direct Transition Metal-Free C-H Functionalization and Electrochemical, Photophysical, and Charge Mobility Characterization

Herein, we describe the synthesis of unsymmetrically substituted dibenzo[f,h]furazano[3,4-b]quinoxalines by intramolecular cyclization through direct transition metal-free C-H functionalization. The electrochemical and photophysical properties for several polycycles have been measured. In thin films of the dibenzo[f,h]furazano[3,4-b]quinoxalines, hole mobility is in the order of 10-4 cm2 V-1 s-1. The results show that the HOMO and LUMO energy levels are appropriate for using the compounds as hole-transport materials in thin-film devices, in particular, organic and perovskite solar cells. Copyright © 2020 American Chemical Society.Russian Foundation for Basic Research, RFBR: 18-33-00103-mol_aRussian Science Foundation, RSF: 18-13-00409The research was financially supported by the Russian Science Foundation (project no. 18-13-00409). Y.A.K would like to acknowledge the financial support for the part of the synthetic section from the Russian Foundation for Basic Research (research project no. 18-33-00103-mol_a). The authors are grateful to Grigory A. Kim for carrying out the DFT calculations, which were performed by using “Uran” supercomputer of the Institute of Mathematics and Mechanics of the Ural Branch of the Russian Academy of Sciences. NMR experiments were carried out by using equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds” at the Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences