17 research outputs found
QUINAZOLINONES .13. SYNTHESIS OF 3-[2-(2,3-DIHYDRO-5-PHENYL-4-SUBSTITUTED-3H-1,2,4-TRIAZOLE-3-THIONE-2-YL)-ACETYLAMINO]-2-METHYL-4(3H)-QUINAZOLINONES AND THEIR PHARMACOLOGICAL ACTIVITIES
No full textPHARMACOLOGICAL STUDIES ON QUATERNIZED 4(3H)-QUINAZOLINONES
No full textLocomotor activity-inhibiting, anticonvulsant, muscle relaxant, analgesic, and antimicrobial properties of 2-methyl-3-pyridiniumacetylamino-4(3H)-quinazolinone chloride (1), 2-methyl-3-(4-methylpyridinium)acetylamino-4(3H)-quinazolinone chloride (2), 2-methyl-3-(4-ethylpyridinium)acetylamino-4(3H)-quinazolinone chloride (3), 2-methyl-3-(3-carboxamidopyridinium)acetylamino-4(3H)-quinazolinone chloride (4), and 2-methyl-3-(4-carboxamidopyridinium)acetylamino-4(3H)-quinazolinone chloride (5) were investigated. The locomotor activity-inhibiting properties and anticonvulsant activity of 2 were almost equal to those of methaqualone. The analgesic activities of 2 and 3 in the hot-plate test were equal to that of aspirin, whereas in the Koster test, the analgesic activity of 2 was higher. The compounds did not exhibit antimicrobial or muscle relaxant properties. Most active compounds had higher lipophilicity values than those of inactive compounds
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME ARYLHYDRAZONES OF 4-[(2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-YL)AZO]BENZOIC ACID HYDRAZIDE
No full textEVALUATION OF SOME ARYLHYDRAZONES OF N-2-ARYLIDENEBENZYLIC ACID HYDRAZIDE AS ANTIMICROBIAL AGENTS
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Spectrophotometric and Spectrofluorimetric Methods for the Determination of Tranexamic Acid in Pharmaceutical Formulation
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