Impact of Shared Values & Power on Successful Mentoring for Minorities in STEM

The study aimed to identify characteristics of mentoring programs that benefit (or do not benefit) women, Black, Indigenous, and people of color, and first-generation college students and increase their retention and continuation in STEM. The hypothesis was that shared values and power dynamics can drive the success (or failure) of mentoring these students in STEM. Specifically, we studied the impact of patented technology “Epixego” – an online mentoring and employment ecosystem – and the accompanying training program that both explicitly incorporate shared values and account for power dynamics in mentoring. The research was an intentional collaboration across UC Davis, UC Merced, and UC Berkeley, with the former two having the distinction of being Hispanic-Serving Institutions (HSI) in a near-peer mentoring model. Research indicates that access to social capital via mentoring is critical for historically excluded students’ sense of belonging, self-efficacy, and retention (Holloway-Friesen, 2019). The research used a mixed-method approach consisting of a quantitative assessment of the mentoring intervention using preand post-intervention surveys and qualitative data from focus groups

Synthesis and utility of new amine/nucleobase addition products of allenylphosphonates

In the reaction of allenylphosphonates with amines/nucleobases, depending on the amine and the allenylphosphonate, either Z- or E-vinylphosphonate or allylphosphonate as a single isomer with a β-amino functionality was isolated. A simple route to phosphonates with a β-NH2 group is developed by direct reaction with ammonia. In reactions with adenine, three different modes of reaction, with one of them involving an unusual cyclisation, are observed. The utility of (enamino)allyl phosphonate products thus obtained in the synthesis of (enamino)-1,3-butadienes via Horner-Wadsworth-Emmons (HWE) reaction is also demonstrated

Cell count moments in the halo model

We study cell count moments up to fifth order of the distributions of haloes, of halo substructures as a proxy for galaxies, and of mass in the context of the halo model and compare theoretical predictions to the results of numerical simulations. On scales larger than the size of the largest cluster, we present a simple point cluster model in which results depend only on cluster-cluster correlations and on the distribution of the number of objects within a cluster, or cluster occupancy. The point cluster model leads to expressions for moments of galaxy counts in which the volume-averaged moments on large scales approach those of the halo distribution and on smaller scales exhibit hierarchical clustering with amplitudes Sk determined by moments of the occupancy distribution. In this limit, the halo model predictions are purely combinatoric, and have no dependence on halo profile, concentration parameter or potential asphericity. The full halo model introduces only two additional effects: on large scales, haloes of different mass have different clustering strengths, introducing relative bias parameters; and on the smallest scales, halo structure is resolved and details of the halo profile become important, introducing shape-dependent form factors. Because of differences between discrete and continuous statistics, the hierarchical amplitudes for galaxies and for mass behave differently on small scales even if galaxy number is exactly proportional to mass, a difference that is not necessarily well described in terms of bia

In vivo antioxidant potential of lepidium sativum l. Seeds in albino rats using cisplatin induced nephrotoxicity

The present study was designed to investigate to possible potential nephrocurative, nephroprotective activity and in vivo antioxidant potential of 200mg/kg and 400mg/kg ethanolic extract of Lepidium sativum L. seeds was use to against cisplatin (5mg/kg, i.p.) induced nephrotoxicity. The experimental protocol designed as the animals were divided into six groups (n=6) like control, model control, two curative (200mg/kg and 400mg/kg), and two protective groups (200mg/kg and 400mg/kg, were received vehicle, cisplatin, cisplatin + extract, and extract + cisplatin respectively. After 6th days, blood collected from retro-orbital sinus of rats and determined urea and creatinine level in serum of each group after then rats were sacrificed for quantitative estimation of various enzymes and ATPase content in kidney tissue. A single dose of cisplatin induced loss in body weight, increase urine excretion, increased urea & creatinine level in serum; it was significantly recovered by 200mg/kg and 400mg/kg in curative and protective groups. The enzyme estimation in kidney tissue it found that increase malondialdehyde, superoxide dismutase, catalase and reduced glutathione level, it was significantly monitored by 200mg/kg and 400mg/kg in curative and protective groups. These are defined as vivo antioxidant potential. The level of brush border enzymes like Na+ / K+ ATPase, Ca++ ATPase and Mg++ATPase were found significantly reduced after single dose cisplatin injection. It was overcome by treatment of same extract in curative and protective groups. Finally it is concluded that the present study data conformed nephrotoxicity induced by cisplatin due oxidative stress and ethanolic extract of Lepidium sativum L. seeds may have nephroprotective and curative activity.Keywords: Cisplatin; Nephrotoxicity; urea; creatinine; glutathione; Lipid peroxidatio

In vivo antioxidant potential of lepidium sativum l. Seeds in albino rats using cisplatin induced nephrotoxicity

The present study was designed to investigate to possible potential nephrocurative, nephroprotective activity and in vivo antioxidant potential of 200mg/kg and 400mg/kg ethanolic extract of Lepidium sativum L. seeds was use to against cisplatin (5mg/kg, i.p.) induced nephrotoxicity. The experimental protocol designed as the animals were divided into six groups (n=6) like control, model control, two curative (200mg/kg and 400mg/kg), and two protective groups (200mg/kg and 400mg/kg, were received vehicle, cisplatin, cisplatin + extract, and extract + cisplatin respectively. After 6th days, blood collected from retro-orbital sinus of rats and determined urea and creatinine level in serum of each group after then rats were sacrificed for quantitative estimation of various enzymes and ATPase content in kidney tissue. A single dose of cisplatin induced loss in body weight, increase urine excretion, increased urea & creatinine level in serum; it was significantly recovered by 200mg/kg and 400mg/kg in curative and protective groups. The enzyme estimation in kidney tissue it found that increase malondialdehyde, superoxide dismutase, catalase and reduced glutathione level, it was significantly monitored by 200mg/kg and 400mg/kg in curative and protective groups. These are defined as vivo antioxidant potential. The level of brush border enzymes like Na+ / K+ ATPase, Ca++ ATPase and Mg++ATPase were found significantly reduced after single dose cisplatin injection. It was overcome by treatment of same extract in curative and protective groups. Finally it is concluded that the present study data conformed nephrotoxicity induced by cisplatin due oxidative stress and ethanolic extract of Lepidium sativum L. seeds may have nephroprotective and curative activity.Keywords: Cisplatin; Nephrotoxicity; urea; creatinine; glutathione; Lipid peroxidatio

Razvoj i karakterizacija mukoadhezivnih flastera salbutamol sulfata za jednosmjernu bukalnu isporuku

Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated patches ranged between 0.2 and 0.4 mm and showed an increase in mass whenever PEG-400 was used as plasticizer. The surface pH of all patches approached neutral. Eight formulations which had shown high folding endurance (> 300) were selected for evaluation. Patches prepared with PEG-400 showed a high swelling index. The residence time of the tested patches ranged between 105 and 130 min. Formulations A10, A32, B10 and B32 fitted the Higuchi model best, whereas formulations A19 and B19 showed super case II transport drug release. Stability studies indicated that there was no change in the chemical and physical characteristics during the test period of 6 months.U radu je opisana priprava flastera za bukalnu primjenu upotrebom različitih omjera pet vodotopljivih polimera i PEG-400/PG kao plastifikatora. Potpuni 32 faktorijalni dizajn upotrebljen je za dizajniranje eksperimenata za svaku kombinaciju polimera. Flasteri su postavljeni na jednu stranu usta s vodonepropusnom podlogom, koja omogućava jednosmjerno oslobađanje lijeka. Debljina flastera varirala je između 0,2 i 0,4 nm. Flasteri s PEG-400 bili su malo veće mase. pH na površini svih flastera bio je blizu neutralnog. Osam pripravaka vrlo otpornih na presavijanje (300) izabrano je za daljnju evaluaciju. Flasteri pripravljeni s PEG 400 imali su veliku sposobnost bubrenja. Flasteri su se zadržali na mjestu primjene između 105 i 130 min. Pripravci A10, A32, B10 i B32 najbolje su slijedili Higuchijev model, dok su pripravci A19 i B19 pokazivali anomalno oslobađanje koje ne slijedi Fickov zakon. Ispitivanje stabilnosti pokazalo je da ne postoje promjene u kemijskim i fizikalnim svojstvima pripravaka tijekom 6 mjeseci

Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms

The microtubule-associated protein tau exists as six isoforms created through the splicing of the second, third, and tenth exons. The isoforms are classified by their number of N-terminal exons (0N, 1N or 2N) and by their number of microtubule-binding repeat regions (3R or 4R). Hyperphosphorylated isoforms accumulate in insoluble aggregates in Alzheimer’s disease and other tauopathies. These neurodegenerative diseases can be categorized based on the isoform content of the aggregates they contain. Hyperphosphorylated tau has the general characteristics of an upward electrophoretic shift, decreased microtubule binding, and an association with aggregation. Previously we have shown that a combination of seven pseudophosphorylation mutations at sites phosphorylated by GSK-3β, referred to as 7-Phos, induced several of these characteristics in full-length 2N4R tau and led to the formation of fewer but longer filaments. We sought to determine whether the same phosphorylation pattern could cause differential effects in the other tau isoforms, possibly through varied conformational effects. Using in vitro techniques, we examined the electrophoretic mobility, aggregation properties and microtubule stabilization of all isoforms and their pseudophosphorylated counterparts. We found that pseudophosphorylation affected each isoform, but in several cases certain isoforms were affected more than others. These results suggest that hyperphosphorylation of tau isoforms could play a major role in determining the isoform composition of tau aggregates in disease

Synthesis and Crystal Structure of a Copper(II) Benzoate Complex Bearing a Bis-2,2′-Tetrahydrofuryl Peroxide Moiety

Complex [Cu2(ben)4·2THF−(η1–O2)]∞ (2) (ben=C6H5CO2− benzoate; THF=tetrahydrofuran) was isolated when a solution of Cu2(ben)4·2THF (1) in THF upon natural sunlight irradiation yields crystals suitable for single-crystal X-ray diffraction analysis. 2, crystallized in the C2/c monoclinic space group, Z=8, V=3394.2 (4) Å3, and the unit cell parameters a=9.7935(7) Å, b=19.0055 (13) Å, c=18.2997 (13) Å, α=90°, β=94.7996 (11)º and γ=90°. This is the first example of a polymeric copper(II) carboxylate compound stabilizing a peroxo group via its apical ligand (THF molecule). Additionally, 2 was also characterized by elemental analysis, Fourier-transformed infrared spectroscopy (FTIR) and Raman spectroscopyUniversidad de Costa Rica/[804-B7-279]/UCR/Costa RicaUniversidad de Costa Rica/[804-B0-650]/UCR/Costa RicaUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de QuímicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ