Wound healing and anti-inflammatory effects of recombinant human angiogenin

New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental ani mals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products

Rhabdomyolysis Associated with Fenofibrate Monotherapy in a Patient with Chronic Myelogenous Leukemia

Rhabdomyolysis associated with fenofibrate monotherapy is extremely rare. Here, we report a rare case of rhabdomyolysis of the psoas muscle in an 82-year-old man with chronic myelogenous leukemia (CML). He was prescribed fenofibrate because of a hypertriglyceridemia. The patient reported generalized muscle pain and right abdominal pain while receiving fenofibrate monotherapy. An abdominal computed tomography scan and an abdominal ultrasound showed a large and low attenuation and high echogenicity, respectively, in the right middle abdominal area. Laboratory values included a serum creatine concentration of 4.1 mg/dl and a creatinine phosphokinase concentration of 5,882 IU/l. During laparotomy, a large hematoma and necrotic mass was identified in the right psoas muscle. Histological examination revealed that the resected specimens were of the psoas muscle with irregular fiber sizes, degenerating fibers surrounding the inflammatory reaction, and fiber necrosis that is typical for polymyositis. Based on these findings and the clinical history, a diagnosis of fenofibrate-induced rhabdomyolysis was made. To the best of our knowledge, no patient has ever been diagnosed with fulminant psoas rhabdomyolysis due to a fenofibrate monotherapy. This report details the rare case of rhabdomyolysis in a patient with CML associated with fenofibrate monotherapy and offers a review of the literature

Morphological features of skin changes in the undetermined clinical picture of psoriasis and atopic dermatitis in children

The purpose of work was to compare pathomorphological changes in biopsy specimens of plaque skin elements in children with undetermined clinical picture of the disease with changes in typical forms of psoriasis and atopic dermatitis.Цель работы – сравнить патоморфологические изменения в биоптатах бляшечных элементов кожи при неопределенной клинической картине заболевания у детей с изменениями при типичных формах псориаза и атопического дерматита

Ранозаживляющее и противовоспалительное действие рекомбинантного ангиогенина человека

New effective wound healing agents are a priority for modern clinical pharmacology. A promising approach would be to develop medicinal products that promote angiogenesis, which is a critical step in wound healing. The aim of the study was to evaluate the wound healing effect of a medicinal product based on recombinant human angiogenin in gel form in various experimental models. Materials and methods: white outbred male rats were used as experimental ani mals. The study compared healing effects of a regenerating product containing recombinant human angiogenin (0.0025%) in gel form and a reference product in full-thickness excision, incision, and burn wound models. The healing effect of the test product in treating chronic wounds was assessed in a model of alloxan-induced diabetes mellitus. The anti-inflammatory effect of the test product containing recombinant human angiogenin was compared with that of another reference product in a model of adjuvant-induced arthritis. Results: according to the study, the test product based on recombinant human angiogenin exerts higher wound healing effect in treating excision, incision, and burn wounds than the reference product (Solcoseryl gel). Being applied, the test product intensifies tissue repair in chronic wounds in the model of alloxan-induced diabetes. The dissociation of necrotic tissues and the progression towards epithelialisation at wound edges are more rapid. The anti-inflammatory effect of the test product based on recombinant human angiogenin is comparable with that of the reference product (Diclofenac gel). Conclusions: the test product based on recombinant human angiogenin in gel form was found to have pronounced wound healing and anti-inflammatory effects comparable with those of reference products.Создание новых эффективных ранозаживляющих средств является актуальной задачей современной клинической фармакологии. Одним из перспективных направлений представляется разработка препаратов для стимуляции ангиогенеза, который является критическим этапом процесса заживления ран. Цель работы: оценить ранозаживляющее действие препарата на основе рекомбинантного ангиогенина человека в виде геля на различных экспериментальных моделях. Материалы и методы: в качестве экспериментальных животных использовали белых беспородных крыс-самцов. Исследовано ранозаживляющее действие препарата на основе рекомбинантного ангиогенина человека (0,0025%) в виде геля относительно препарата сравнения на моделях плоскостной кожно-мышечной, линейной и ожоговой раны. Ранозаживляющее действие исследуемого препарата при лечении длительно незаживающей раны охарактеризовано на модели аллоксанового сахарного диабета. На модели адъювантного артрита оценено противовоспалительное действие препарата на основе рекомбинантного ангиогенина человека относительно препарата сравнения. Результаты: установлена более высокая ранозаживляющая активность препарата на основе рекомбинантного ангиогенина человека относительно препарата сравнения (гель Солкосерил) для плоскостной кожно-мышечной раны, линейной и ожоговой ран. При применении исследуемого препарата ускоряется процесс репарации тканей при лечении длительно незаживающей раны на модели аллоксанового сахарного диабета. Отмечено более быстрое расплавление некротических масс и переход к эпителизации краев раны. Установлена противовоспалительная активность препарата на основе рекомбинантного ангиогенина человека, по эффективности сравнимая с действием препарата сравнения (гель Диклофенак). Выводы: определено наличие у препарата на основе рекомбинантного ангиогенина человека в виде геля выраженных ранозаживляющих и противовоспалительных свойств, сопоставимых с препаратами сравнения

Personality profiles and the "russian soul": Literary and scholarly views evaluated

Many domestic and foreign observers have claimed that Russians have a unique constellation of personality traits that mirrors their distinctive historical and cultural experience. To examine the hypothesized uniqueness of Russian personality, members of the Russian Character and Personality Survey collected data from 39 samples in 33 administrative areas of the Russian Federation. Respondents (N = 7,065) identified an ethnically Russian adult or college-aged man or woman whom they knew well and rated the target using the Russian observer-rating version of the Revised NEO Personality Inventory. The mean personality profile of Russians was very similar to the international average based on 50 different countries, debunking the myth of a unique Russian soul.The small variations from world norms did not converge with depictions of Russian national character in fiction and the scholarly literature. New items intended to capture distinctive, emic aspects of Russian personality provided no new information beyond the familiar Big Five dimensions. Religion, ethnicity, and beliefs about the uniqueness of the Russian character and the malleability of personality traits had little effect on personality ratings. Perceptions of the Russian soul do not seem to be based on the personality traits of Russians

Update on the Combined Analysis of Muon Measurements from Nine Air Shower Experiments

Over the last two decades, various experiments have measured muon densities in extensive air showers over several orders of magnitude in primary energy. While some experiments observed differences in the muon densities between simulated and experimentally measured air showers, others reported no discrepancies. We will present an update of the meta-analysis of muon measurements from nine air shower experiments, covering shower energies between a few PeV and tens of EeV and muon threshold energies from a few 100 MeV to about 10GeV. In order to compare measurements from different experiments, their energy scale was cross-calibrated and the experimental data has been compared using a universal reference scale based on air shower simulations. Above 10 PeV, we find a muon excess with respect to simulations for all hadronic interaction models, which is increasing with shower energy. For EPOS-LHC and QGSJet-II.04 the significance of the slope of the increase is analyzed in detail under different assumptions of the individual experimental uncertainties

Influence of feeding the developed fodder additive on the development of internal organs of egg cross chicken

The article describes the results of studies of the effect of a natural feed supplement based on the bottom sediments of the Khan Lake of the Krasnodar Territory on the development of internal organs of young laying hens. It has been experimentally confirmed that there are no pathologies in the structure of internal organs of the poultry of experimental groups when feeding the studied fodder additive

Evaluation of the air-dry mass of vetch-cereal grass mixtures according to their optimality in the ratio of neutral-detergent (NDF) and acid-detergent fiber (ADF)

On the experimental field an experiment was laid to study the productivity of two types of winter vetch: Hungarian vetch (Vicia pannonica Granz) varieties Orlan and Chernomorskaya and downy vetch (Vicia villosa op Roth) varieties Lugovskaya 2 and Glinkovskaya. The vetch was sown in a mixture with winter wheat (Triticum aestivum L.) variety Tanya. Various doses of mineral fertilizers. Phosphorus (superphosphate) and potassium (potassium chloride) were introduced during sowing, nitrogen (calcium nitrate) – as early spring feeding. As a control, we studied the variety of furry vetch Lugovskaya 2, since this is the most popular variety of winter vetch in the Krasnodar Territory. The soils of the experimental plots are represented by leached, low-humus heavy loamy powerful chernozem. Due to the limited feed intake, the diets of high-yielding cows are rich in highly digestible non-structural carbohydrates (ADF), which fermentation leads to the formation of a large amount of propionic acid in the rumen with a strong acidic effect and, conversely, NDF fermentation is slower and on a smaller scale. The variant winter wheat Tanya + winter vetch Lugovskaya 2 - is closer to the optimum in the second cut. The rest of the experimental options of vetchwheat and vetch-triticale grass mixtures also have a negative fiber balance, which is not acceptable for feeding high-producing dairy cattle

Studying productivity of bester yearling in reservoirs of different types

The article provides a comparative assessment of traditional and developed fish-breeding tanks for keeping bester yearlings. As a result of growing fish in different reservoirs, it’s been found that when using the “ICA-2” and “INTEX” tanks, there is practically no difference. When comparing the use of "ICA-2" and a semi-buried adaptive reservoir, it’s been found that the weight of fish was higher in the second case, when compared with the benchmark, by 1.5%, the average daily gain - by 5.3%, the coefficient of nutrition - by 1, 2%

The TECHNOLOGY of Producing Biohumus and the Study of Its Qualitative Indicators

This article presents the results from the development of a technology for producing biohumus from the feces of cattle and winter wheat straw in a biodynamic fermenter. Nitrifying agents are important for soil fertility, which is dependent on the intensity of the nitrification process. This group includes aerobic cellulose-destroying microorganisms, denitrifiers and sulfate-reducing bacteria. The ratio of these groups and their composition are changing. Therefore, the study of the quantitative ratio of microbial communities involved in the formation of biohumus was of considerable scientific interest. During the microbiological analyses, a large number of microorganisms were found to be involved in the decomposition of the organic compounds. Aminoautotrophic microorganisms represented the largest physiological group of microorganisms in the biohumus. The chemical composition of the biohumus was determined during the study and a sanitary microbiological analysis was performed. The content of gross forms of elements in the humic extract was also examined. The humic extract from the biohumus was a brown liquid with 15 g / l of humic acids, 5.0 g / l of fulvic acids, and gross forms of elements (potassium, phosphorus, nitrogen). The dry matter in the biohumus was 1.0% of the total composition and contained 0.1% nitrogen, 0.03% phosphorus P2O5 and 0.01% potassium K2O. It was found that high-quality organic fertilizer can be obtained using this technology. Keywords: biohumus, humic extract, chemical composition, sanitary-microbiological analysis, organic fertilize