Features of the Development of the Modern Finnish Feminist Movement

The Finnish state has created a high level of social protection for its women. Thanks to social support, Finnish women have become economically independent and have been given the opportunity for personal and professional development. Gender equality is inextricably linked to democracy, human rights and social justice. The Finnish state actively supports the women’s movement and in particular feminist organizations. The process of involving women in politics was slow. The first feminist party, Feministinen puolue, is active in Finland

ON THE DIAGNOSTICS OF SAGITTAL OCCLUSION ANOMALIES

In the known classifications, there is no terminological wording as asymmetrical sagittal occlusion of segments of dentition in lateral areas. The work complemented classification of sagittal occlusion anomalies in the lateral areas of dentition of following types of asymmetric occlusion: Type I of asymmetrical sagittal occlusion: correct (neutral - class 1] ratio of lateral teeth on one side and distal (class 2) ratio on the other side. Type II of asymmetrical sagittal occlusion: correct (neutral - class 1] ratio of lateral teeth on one side and mesial (class 3) ratio on the other side. Type III of asymmetrical sagittal occlusion: distal (class 2] ratio of lateral teeth on one side and mesial (class 3) ratio on the other side. Type of asymmetrical sagittal occlusion is not the basis for the establishment of gravity anomalies

CIVIL SOCIETY AND STATE: THE INSTITUTION OF PUBLIC CONTROL IN THE LIGHT OF MODERN RESEARCH PRACTICES IN IRKUTSK REGION

The article covers the place and role of the institution of public control in the mechanisms of the interaction of civil society and state. Basing on the sociological surveys conducted in Irkutsk region in 2008-2017, the article grounds the dynamics of formation of public control in the development of civil society in a region. The authors use the mechanisms of public-state partnership to define the concept of "effective public control" over the governmental bodies and municipal authorities. The article shows the tendency of the increasing role of public bodies (civic chambers, public councils) in the decision-making process of the executive branch as well as in the realization of the decisions

Clinical and roentgenological aspects of diagnosis and treatment of temporomandibular joint pathology

The article presents the occurrence of temporomandibular joint pathology (20,9 %) in children of prepubertal age. It was revealed that habitual dislocation that appears on the background of asymmetric occlusion with close position of teeth in frontal and lateral areas of dentition is typical for this age group. It was determined that clinical signs of TM] pathology in children and adults are different: pain syndrome and noise effect at the lower jaw movements are not typical for children in contrast to the adults. According to the data of outpatient's cards the structure of nosologic forms of pathology during different periods of occlusion formation is defined. It was determined that TM] pathology begins to form in preschool age and later on its frequency increases. The analysis of morbidity by sex showed that women have TM] pathology more often and also they have age tendency to the aggravation of the pathology that develops in future in appearance of dislocations of intraarticular disks. The article suggests the differentiated approach tactics for the treatment of TM] diseases that was rather effective

Phantasus, a web application for visual and interactive gene expression analysis

Transcriptomic profiling became a standard approach to quantify a cell state, which led to the accumulation of huge amount of public gene expression datasets. However, both reuse of these datasets or analysis of newly generated ones requires significant technical expertise. Here, we present Phantasus: a user-friendly web application for interactive gene expression analysis which provides a streamlined access to more than 96,000 public gene expression datasets, as well as allows analysis of user-uploaded datasets. Phantasus integrates an intuitive and highly interactive JavaScript-based heatmap interface with an ability to run sophisticated R-based analysis methods. Overall Phantasus allows users to go all the way from loading, normalizing, and filtering data to doing differential gene expression and downstream analysis. Phantasus can be accessed online at https://alserglab.wustl.edu/phantasus or can be installed locally from Bioconductor (https://bioconductor.org/packages/phantasus). Phantasus source code is available at https://github.com/ctlab/phantasus under an MIT license

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination may contribute to malignant transformation. Here, we identified the de-ubiquitinase OTUB1 as a negative regulator of RAS mono- and di-ubiquitination. OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane. OTUB1 promotes RAS activation and tumorigenesis in wild-type RAS cells. An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 phosphorylation, high Ki67 score, and poorer patient survival. Our results strongly indicate that dysregulation of RAS ubiquitination represents an alternative mechanism of RAS activation during lung cancer development

Development of bioceramic material for spinal surgery implants

Highly porous zirconia-based ceramics were prepared. The ceramic samples sintered at 1600°C had porosities from 40% to 43%, with pore size ranges as follows: "big pore" 100-220 pm and "small pore" 0.8-8 pm. This makes the ceramic structure to be very similar to the structure of the natural spinal bone. The level of mechanical properties of the synthesized zirconia-based ceramics is determined by the pore sizes. The values of the compressive strength and the effective Young's modulus are very similar to those characteristics of the natural spinal bone

Socio-demographic factors of social development in the conditions of post-global reality

The article considers the system-wide impact of socio-demographic factors in the social development of countries and regions in the context of post-global reality. It is emphasized that modern demographic changes are the result of global transformation processes. The permanent relationship of demographic processes with climate change on the planet, the emergence and spread of new infectious diseases, the development of digital technologies, etc. is shown. The meaning of the concept of “post-global reality” is clarified in terms of the uniqueness of modern conditions of social development, in which the desire of a person and society for “openness” is traced in the conditions of growing “social closeness” and “social tension”, which indicates the limited possibilities of society in regulating sociodemographic processes. It is concluded that the spread of new infectious diseasesin the 21st century, especially the new coronavirus infection COVID-19, has contributed to the emergence of new groups of problems associated with a deterioration in health status, an increase in mortality, a decrease in the reproductive and labor potential of the population. The authors substantiate the formation of the concept of “global determinism” in terms of the role of socio-demographic factors in the social development of countries and regions in the context of post-global reality. Among the most influential concepts that contribute to its development are “geographical determinism”, “economic determinism” and actually “demographic determinism”. Based on the materials of a sociological study, it is shown that new external and internal challenges and new crises of a systemic order in the 21st century contribute to social upheaval and profound transformations. It was revealed that the sustainability of social development in the focus of public opinion is directly related to effective public administration and regulation, the effectiveness of national security strategies and strategies for the socio-economic and socio-demographic development of countries and regions

On the Strategy for the Development of the Information Society of the Russian Federation for 2017-2030

The article defines the concept of the information society, considers the strategy of the development of the information society in the Russian Federation. In the main part, the state of the development of the information society in the Russian Federation was studied using international indices: the ICT development index, the network readiness index (NRI), the e-government development index (EGDI), the knowledge economy index. A cluster analysis of the state of the information society as a whole was also conducted. The conclusions give recommendations on the improvement of the system of indicators, the mechanism of working with it, and documents clarifying the Strategy for the Development of the Information Society in the Russian Federation for 2017-2030. This will allow increasing the values of individual ratings, as well as the common place of Russia in a single information space

Morphological verification of the first missed abortion

Objective. The study aimed to compare the level of INF a2 immunoexpression in tissues obtained during medical abortion with the corresponding level of IFNa2 expression in a retained fetal egg tissues after the first missed abortion. The authors compared the anamnestic data on previous inflammatory diseases of the genital tract with the results of an extended morphological study of the material obtained during the evacuation of the contents of the uterine cavity during the first non-developing pregnancy in the first trimester.Materials and methods. The study included 15 patients with first-time missed abortions caused by a viral infection (6-8 weeks of pregnancy). All patients demonstrated either recurrent herpes simplex labialis/genitalis or PCR confirmed HSV, HPV, CMV. Exclusion criteria were recurrent miscarriage, blighted ovum, endocrinopathies, male factor infertility, and other causes of miscarriage. The comparison group included 20 women of the same age that chose to undergo a medical abortion.Results. In patients from the comparison group, the main producer of IFN a2 was syncytiotrophoblast as well as maternal decidual cells in the parietal endometrium and uteroplacental area. In the main group, manifested hematogenous infection (microabscesses, vasculitis, lymphocytic and macrophage infiltration) with dystrophy and necrosis of decidual maternal cells and secondary pathological changes in the placental villi were diagnosed, which led to a significant decrease in the IFN a2 immunoexpression in all the studied cells.Conclusion. The lack of anamnestic data on previous urogenital infections does not exclude the etiological role of the inflammatory component in the genesis of non-developing pregnancy. First-time occurred pregnancy loss requires adequate postoperative interferon therapy and a thorough examination of a couple