Synthesis and pharmacological activity of some 2, 3-diphenylindole derivatives

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Synthesis of novel quinoxaline carboxylic acid derivatives for antimicrobial investigation

1480-14856,7-Dimethylquinoxaline-2,3-dicarboxylic acid anhydride 1 on treatment with binucleophiles 2 in ethanol at reflux condition affords 2-carboxamidoquinoxaline-3-carboxylic acid derivatives 3a-e. The biscarboxamido derivatives 4a,b are obtained upon treatment of 3a,b with the anhydride derivative 1 which are converted into the corresponding bispyrrolo derivatives 5a,b. Acetylation of 3a,b with acetic anhydride at room temperature yields the acetamido derivatives 6a,b.While, 3a,b on refluxing with acetic anhydride, afford the pyrrolo[3,4-d]quinoxaline derivatives 7a,b. The pyrrole ring in compounds 7a,b is opened via their reaction with the aromatic amines under fusion condition. Condensation of compound 3a with aromatic aldehydes in DMF furnishes the Schiffs bases 9a,b.While, on repeating the reaction under fusion condition caused decarboxylation to give the corresponding Schiffs bases 10a,b. Some of the prepared compounds are tested in vitro for their antimicrobial activities

Synthesis of Novel 1-Substituted and 1,9-Disubstituted-1,2,3,4-tetrahydro-9H-Carbazole Derivatives as Potential Anticancer Agents

Condensation of 1-acetyl-1,2,3,4-tetrahydro-9H-carbazole (2) with some amino compounds furnished the corresponding imino derivatives 3a-e. Compound 3a reacted with chloroacetic acid and underwent cyclization to give the thiazolidine derivative 5. Also, treatment of 3c with thionyl chloride caused cyclization to yield the [1,2,6]thiadiazino derivative 6, which gave the corresponding N-formyl derivative 7 upon heating with ethyl formate. In addition, interaction of 3d with ethyl cyanoacetate yielded the monoamide of malonic acid derivative 8. Acylation of carbazole 1 with succinoyl chloride or phenylacetyl choride produced the corresponding azepine (11) and 1,9-diphenyl acetyl derivatives (14), respectively. Compounds 11, 14 were further reacted to give the carbazole derivatives 12, 13 and 15a,b. The cytotoxic activity for some of the prepared compounds against breast cancer B20 is discussed