Inhomogeneous reionization and the polarization of the cosmic microwave background

In a universe with inhomogeneous reionization, the ionized patches create a second order signal in the cosmic microwave background polarization anisotropy. This signal originates in the coupling of the free electron fluctuation to the quadruple moment of the temperature anisotropy. We examine the contribution from a simple inhomogeneous reionization model and find that the signal from such a process is below the detectable limits of the Planck Surveyor mission. However t he signal is above the fundamental uncertainty limit from cosmic variance, so th at a future detection with a high accuracy experiment on sub-arcminute scales is possible.Comment: 10 pages, 2 eps figures, final version accepted for publication in ApJ Letter

A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in sorsby's fundus dystrophy

Sorsby’s fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age. It has been shown to be caused by mutations in the gene for tissue inhibitor of metalloproteinases-3 (TIMP-3). Five different mutations have previously been identified, all introducing an extra cysteine residue into exon 5 (which forms part of the C-terminal domain) of the TIMP-3 molecule; however, the significance of these mutations to the disease phenotype was unknown. In this report, we describe the expression of several of these mutated genes, together with a previously unreported novel TIMP-3 mutation from a family with SFD that results in truncation of most of the C-terminal domain of the molecule. Despite these differences, all of these molecules are expressed and exhibit characteristics of the normal protein, including inhibition of metalloproteinases and binding to the extracellular matrix. However, unlike wild-type TIMP-3, they all form dimers. These observations, together with the recent finding that expression of TIMP-3 is increased, rather than decreased, in eyes from patients with SFD, provides compelling evidence that dimerized TIMP-3 plays an active role in the disease process by accumulating in the eye. Increased expression of TIMP-3 is also observed in other degenerative retinal diseases, including the more severe forms of agerelated macular degeneration, the most common cause of blindness in the elderly in developed countries. We hypothesize that overexpression of TIMP-3 may prove to be a critical step in the progression of a variety of degenerative retinopathies

Large Scale Structure Forecast Constraints on Particle Production During Inflation

Bursts of particle production during inflation provide a well-motivated mechanism for creating bump like features in the primordial power spectrum. Current data constrains these features to be less than about 5% the size of the featureless primordial power spectrum at wavenumbers of about 0.1 h Mpc^{-1}. We forecast that the Planck cosmic microwave background experiment will be able to strengthen this constraint to the 0.5% level. We also predict that adding data from a square kilometer array (SKA) galaxy redshift survey would improve the constraint to about the 0.1% level. For features at larger wave-numbers, Planck will be limited by Silk damping and foregrounds. While, SKA will be limited by non-linear effects. We forecast for a Cosmic Inflation Probe (CIP) galaxy redshift survey, similar constraints can be achieved up to about a wavenumber of 1 h Mpc^{-1}.Comment: 10 pages. Matches PRD accepted versio

Secondary CMB anisotropies in a universe reionized in patches

In a universe reionized in patches, the Doppler effect from Thomson scattering off free electrons generates secondary cosmic microwave background (CMB) anisotropies. For a simple model with small patches and late reionization, we analytically calculate the anisotropy power spectrum. Patchy reionization can, in principle, be the main source of anisotropies on arcminute scales. On larger angular scales, its contribution to the CMB power spectrum is a small fraction of the primary signal and is only barely detectable in the power spectrum with even an ideal, i.e. cosmic variance limited, experiment and an extreme model of reionization. Consequently patchy reionization is unlikely to affect cosmological parameter estimation from the acoustic peaks in the CMB. Its detection on small angles would help determine the ionization history of the universe, in particular the typical size of the ionized region and the duration of the reionization process.Comment: 7 pages, 2 figures, submitted to Ap

Age problem in holographic dark energy

We study the age problem of the universe with the holographic DE model introduced in [21], and test the model with some known old high redshift objects (OHRO). The parameters of the model have been constrained using the SNIa, CMB and BAO data set. We found that the age of the old quasar APM 08 279+5255 at z = 3.91 can be described by the model.Comment: 13 page

The Damping Tail of CMB Anisotropies

By decomposing the damping tail of CMB anisotropies into a series of transfer functions representing individual physical effects, we provide ingredients that will aid in the reconstruction of the cosmological model from small-scale CMB anisotropy data. We accurately calibrate the model-independent effects of diffusion and reionization damping which provide potentially the most robust information on the background cosmology. Removing these effects, we uncover model-dependent processes such as the acoustic peak modulation and gravitational enhancement that can help distinguish between alternate models of structure formation and provide windows into the evolution of fluctuations at various stages in their growth.Comment: 24pgs, aaspp4, 10 figs. included; supporting material (e.g. color figures) at http://www.sns.ias.edu/~whu/pub.htm

Using the acoustic peak to measure cosmological parameters

Recent measurements of the cosmic microwave background radiation by the Boomerang experiment indicate that the universe is spatially flat. Here some simple back-of-the-envelope calculations are used to explain their result. The main result is a simple formula for the angular scale of the acoustic peak in terms of the standard cosmological parameters: l=193*[1+3(1-Omega_0)/5+(1-h)/5+Omega_Lambda/35].Comment: 4 pages, 1 figure, Explanations have been clarifie

Computing CMB Anisotropy in Compact Hyperbolic Spaces

The measurements of CMB anisotropy have opened up a window for probing the global topology of the universe on length scales comparable to and beyond the Hubble radius. For compact topologies, the two main effects on the CMB are: (1) the breaking of statistical isotropy in characteristic patterns determined by the photon geodesic structure of the manifold and (2) an infrared cutoff in the power spectrum of perturbations imposed by the finite spatial extent. We present a completely general scheme using the regularized method of images for calculating CMB anisotropy in models with nontrivial topology, and apply it to the computationally challenging compact hyperbolic topologies. This new technique eliminates the need for the difficult task of spatial eigenmode decomposition on these spaces. We estimate a Bayesian probability for a selection of models by confronting the theoretical pixel-pixel temperature correlation function with the COBE-DMR data. Our results demonstrate that strong constraints on compactness arise: if the universe is small compared to the `horizon' size, correlations appear in the maps that are irreconcilable with the observations. If the universe is of comparable size, the likelihood function is very dependent upon orientation of the manifold wrt the sky. While most orientations may be strongly ruled out, it sometimes happens that for a specific orientation the predicted correlation patterns are preferred over the conventional infinite models.Comment: 15 pages, LaTeX (IOP style included), 3 color figures (GIF) in separate files. Minor revision to match the version accepted in Class. Quantum Grav.: Proc. of Topology and Cosmology, Cleveland, 1997. The paper can be also downloaded from http://www.cita.utoronto.ca/~pogosyan/cwru_proc.ps.g