1,858 research outputs found

    LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation.

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    The blood-brain barrier (BBB) is a term used to describe the unique properties of central nervous system (CNS) blood vessels. One important BBB property is the formation of a paracellular barrier made by tight junctions (TJs) between CNS endothelial cells (ECs). Here, we show that Lipolysis-stimulated lipoprotein receptor (LSR), a component of paracellular junctions at points in which three cell membranes meet, is greatly enriched in CNS ECs compared with ECs in other nonneural tissues. We demonstrate that LSR is specifically expressed at tricellular junctions and that its expression correlates with the onset of BBB formation during embryogenesis. We further demonstrate that the BBB does not seal during embryogenesis in Lsr knockout mice with a leakage to small molecules. Finally, in mouse models in which BBB was disrupted, including an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and a middle cerebral artery occlusion (MCAO) model of stroke, LSR was down-regulated, linking loss of LSR and pathological BBB leakage

    Coherent states and uncertainty relations for the damped harmonic oscillator with time-dependent frequency

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    Starting with evaluations of propagator and wave function for the damped harmonic oscillator with time-dependent frequency, exact coherent states are constructed. These coherent states satisfy the properties which coherent states should generally have

    Innovation Contests with Entry Auction

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    We consider procurement of an innovation from heterogeneous sellers. Innovations are random but depend on unobservable effort and private information. We compare two procurement mechanisms where potential sellers first bid in an auction for admission to an innovation contest. After the contest, an innovation is procured employing either a fixed prize or a first-price auction. We characterize Bayesian Nash equilibria such that both mechanisms are payoff-equivalent and induce the same efforts and innovations. In these equilibria, signaling in the entry auction does not occur since contestants play a simple strategy that does not depend on rivals' private information

    Prejudice and Racial Matches in Employment

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    We develop a search model in which some employers hold unobservable racial prejudice towards black workers. Prejudiced employers may refuse to hire and may terminate black workers based on their prejudice. Workers do not observe employer prejudice, but they observe the race of their potential supervisor at the firm, which serves as a signal of the employer's prejudice. Jobs in firms with black supervisors hold higher option value for black workers, because they are less likely to face prejudice-based termination. Hence, black workers are willing to accept employment with lower expected match quality from firms with black supervisors. We derive theoretical predictions on differences in observed wages and job stability across supervisor race and prejudice levels. We find empirical support for our predictions using a unique longitudinal dataset with information on the worker's supervisor race matched with state-level measures of prejudice

    Prejudice and Racial Matches in Employment

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    We develop a job search model in which some employers hold unobservable racial prejudice toward black workers. Prejudiced employers may refuse to hire black workers and may terminate them based on their prejudice. Workers do not observe employer prejudice, but instead observe a signal of prejudice status, the presence of a black supervisor. We show that jobs in firms with black supervisors hold higher option value for black workers, because they are less likely to face prejudice-based termination. Hence, black workers are willing to accept employment with lower expected match quality from firms with black supervisors. We derive theoretical predictions on racial differences in observed wages and job stability across supervisor races and variations in local prejudice levels. We find empirical support for our predictions using unique longitudinal data with information on the worker's supervisor race matched with state-level measures of prejudice
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