Eicosapentaenoic Acid (EPA) from Fish Oil and Margarine as Bioactive Compound for Anti-inflammation in Occupational Dermatitis

Occupational dermatitis (OCD) is a skin inflammatory disease caused by allergens and irritant agents in the workplace. The disease is related to hypersensitivity reaction, which is correlated with an immunological mechanism (allergic contact dermatitis) and a nonimmunological mechanism (irritant contact dermatitis). Patients with atopic history (rhinitis allergy, asthma, and atopic dermatitis) have a higher risk of contracting OCD. Atopic individuals suffer from barrier skin damage that increases the risk of allergen and irritant penetration. Inflammatory reaction involves T-helper 1 (Th1), which produces cytokine tumor necrosis factor alpha (TNF-α) and interferon-γ (INF-γ), while T-helper 2 (Th2) produces interleukin (IL-4, IL-6, IL-8, IL-10). Eicosapentaenoic acid (EPA) is an omega-3 substance from polyunsaturated free fatty acids (PUFAs)that has been shown to have an anti-inflammatory effect and the ability to decrease macrophage accumulation. In the inflammatory process, EPA inhibits IL-6, IL-8, and TNF-α, which are mediated by the free fatty acid-binding proteins (FABPs). The aim of this study was to determine the bioactivity compound of EPA for anti-inflammatory agents and its target, based on in silico screening. The bioinformatic tools based on reverse docking used in this study were the PubChem compound database, the protein target prediction database, PharmMapper, SwissTargetPrediction, molecular docking software PyRx 0.8, ligand docking, and binding site analysis using PyMOL software. Docking and binding site analysis showed that EPA was able to interact withFABPs, with the binding affinity of EPA with FABP 4 higher (–4.2 kcal/mol) than that of hydrocortisone with FABP 4 (–7.4 kcal/mol). EPA has the same binding site and relative bonding power as the FABPs; thus, it has potential as an alternative anti-inflammatory medicine in OCD. Keywords: occupational dermatitis, eicosapentaenoic acid (EPA), free fatty acid binding proteins (FABPs), reverse dockin

Josephson-phase qubit without tunneling

We show that a complete set of one-bit gates can be realized by coupling the two logical states of a phase qubit to a third level (at higher energy) using microwave pulses. Thus, one can achieve coherent control without invoking any tunneling between the qubit levels. We propose two implementations, using rf-SQUIDs and d-wave Josephson junctions.Comment: REVTeX4, 4pp., 6 EPS figure files; N.B.: "Alec" is my first, and "Maassen van den Brink" my family name. v2: gate universality fleshed out, small fix in d-wave decoherence para, discussion expanded, two Refs. added. v3: some more Refs., a molecular example, and a few minor fixes; final, to appear in PRB Rapid

Evaluation of two mobile health apps in the context of smoking cessation: qualitative study of cognitive behavioral therapy (CBT) versus non-CBT-based digital solutions.

BACKGROUND: Mobile health (mHealth) apps can offer users numerous benefits, representing a feasible and acceptable means of administering health interventions such as cognitive behavioral therapy (CBT). CBT is commonly used in the treatment of mental health conditions, where it has a strong evidence base, suggesting that it represents an effective method to elicit health behavior change. More importantly, CBT has proved to be effective in smoking cessation, in the context of smoking-related costs to the National Health Service (NHS) having been estimated to be as high as £2.6bn in 2015. Although the evidence base for computerized CBT in mental health is strong, there is limited literature on its use in smoking cessation. This, combined with the cost-effectiveness of mHealth interventions, advocates a need for research into the effectiveness of CBT-based smoking cessation apps. OBJECTIVE: The objective of this study was, first, to explore participants' perceptions of 2 mHealth apps, a CBT-based app, Quit Genius, and a non-CBT-based app, NHS Smokefree, over a variety of themes. Second, the study aimed to investigate the perceptions and health behavior of users of each app with respect to smoking cessation. METHODS: A qualitative short-term longitudinal study was conducted, using a sample of 29 smokers allocated to one of the 2 apps, Quit Genius or Smokefree. Each user underwent 2 one-to-one semistructured interviews, 1 week apart. Thematic analysis was carried out, and important themes were identified. Descriptive statistics regarding participants' perceptions and health behavior in relation to smoking cessation are also provided. RESULTS: The thematic analysis resulted in five higher themes and several subthemes. Participants were generally more positive about Quit Genius's features, as well as about its design and information engagement and quality. Quit Genius users reported increased motivation to quit smoking, as well as greater willingness to continue using their allocated app after 1 week. Moreover, these participants demonstrated preliminary changes in their smoking behavior, although this was in the context of our limited sample, not yet allowing for the finding to be generalizable. CONCLUSIONS: Our findings underscore the use of CBT in the context of mHealth apps as a feasible and potentially effective smoking cessation tool. mHealth apps must be well developed, preferably with an underlying behavioral change mechanism, to promote positive health behavior change. Digital CBT has the potential to become a powerful tool in overcoming current health care challenges. The present results should be replicated in a wider sample using the apps for a longer period so as to allow for generalizability. Further research is also needed to focus on the effect of greater personalization on behavioral change and on understanding the psychological barriers to the adoption of new mHealth solutions

Josephson effect in d-wave superconductor junctions in a lattice model

Josephson current between two d-wave superconductors is calculated by using a lattice model. Here we consider two types of junctions, $i.e.$, the parallel junction and the mirror-type junction. The maximum Josephson current $(J_{c})$ shows a wide variety of temperature ($T$) dependence depending on the misorientation angles and the types of junctions. When the misorientation angles are not zero, the Josephson current shows the low-temperature anomaly because of a zero energy state (ZES) at the interfaces. In the case of mirror-type junctions, $J_c$ has a non monotonic temperature dependence. These results are consistent with the previous results based on the quasiclassical theory. [Y. Tanaka and S. Kashiwaya: Phys. Rev. B \textbf{56} (1997) 892.] On the other hand, we find that the ZES disappears in several junctions because of the Freidel oscillations of the wave function, which is peculiar to the lattice model. In such junctions, the temperature dependence of $J_{c}$ is close to the Ambegaokar-Baratoff relation.Comment: 17 pages, 10 figures, using jpsj2.cls and oversite.st

Submaximal Angioplasty for Symptomatic Intracranial Atherosclerotic Disease: A Meta-Analysis of Peri-Procedural and Long-Term Risk

© 2019 by the Congress of Neurological Surgeons. BACKGROUND: Symptomatic intracranial atherosclerotic disease (ICAD) is an important cause of stroke. Although the high periprocedural risk of intracranial stenting from recent randomized studies has dampened enthusiasm for such interventions, submaximal angioplasty without stenting may represent a safer endovascular treatment option. OBJECTIVE: To examine the periprocedural and long-term risks associated with submaximal angioplasty for ICAD based on the available literature. METHODS: All English language studies of intracranial angioplasty for ICAD were screened. Inclusion criteria were as follows: ≥ 5 patients, intervention with submaximal angioplasty alone, and identifiable periprocedural (30-d) outcomes. Analysis was co-nducted to identify the following: 1) periprocedural risk of any stroke (ischemic or hemorrh-agic) or death, and 2) stroke in the territory of the target vessel and fatal stroke beyond 30 d. Mixed effects logistic regression was used to summarize event rates. Funnel plot and rank correlation tests were employed to detect publication bias. The relative risk of periprocedural events from anterior vs posterior circulation disease intervention was also examined. RESULTS: A total of 9 studies with 408 interventions in 395 patients met inclusion criteria. Six of these studies included 113 posterior circulation interventions. The estimated pooled rate for 30-d stroke or death following submaximal angioplasty was 4.9% (95% CI: 3.2%-7.5%), whereas the estimated pooled rate beyond 30 d was 3.7% (95% CI: 2.2%-6.0%). There was no statistical difference in estimated pooled rate for 30-d stroke or death between patients with anterior (4.8%, 95% CI: 2.8%-7.9%) vs posterior (5.3%, 95% CI: 2.4%-11.3%) circulation disease (P \u3e. 99). CONCLUSION: Submaximal angioplasty represents a potentially promising intervention for symptomatic ICAD

Zero-bias conductance peak splitting due to multiband effect in tunneling spectroscopy

We study how the multiplicity of the Fermi surface affects the zero-bias peak in conductance spectra of tunneling spectroscopy. As case studies, we consider models for organic superconductors $\kappa$-(BEDT-TTF)$_2$Cu(NCS)$_2$ and (TMTSF)$_2$ClO$_4$. We find that multiplicity of the Fermi surfaces can lead to a splitting of the zero-bias conductance peak (ZBCP). We propose that the presence/absence of the ZBCP splitting is used as a probe to distinguish the pairing symmetry in $\kappa$-(BEDT-TTF)$_2$Cu(NCS)$_2$.Comment: 7 pages, 7 figure

Effective "Penetration Depth" in the Vortex State of a d-wave Superconductor

The temperature and field dependence of the effective magnetic penetration depth in the vortex state of a d-wave superconductor, as measured by muon spin rotation experiments, is calculated using a nonlocal London model. We show that at temperatures below T^* \propto \sqrt{B}, the linear T-dependence of the effective penetration depth crosses over to a T^3-dependence. This could provide an explanation for the low temperature flattening of the effective penetration depth curves observed in a recent muon spin rotation experiment.Comment: 4 pages, RevTex, 3 Postscript figure

On handling urban informality in southern Africa

In this article I reconsider the handling of urban informality by urban planning and management systems in southern Africa. I argue that authorities have a fetish about formality and that this is fuelled by an obsession with urban modernity. I stress that the desired city, largely inspired by Western notions of modernity, has not been and cannot be realized. Using illustrative cases of top–down interventions, I highlight and interrogate three strategies that authorities have deployed to handle informality in an effort to create or defend the modern city. I suggest that the fetish is built upon a desire for an urban modernity based on a concept of formal order that the authorities believe cannot coexist with the “disorder” and spatial “unruliness” of informality. I question the authorities' conviction that informality is an abomination that needs to be “converted”, dislocated or annihilated. I conclude that the very configuration of urban governance and socio-economic systems in the region, like the rest of sub-Saharan Africa, renders informality inevitable and its eradication impossible

Theory of charge transport in diffusive normal metal / unconventional singlet superconductor contacts

We analyze the transport properties of contacts between unconventional superconductor and normal diffusive metal in the framework of the extended circuit theory. We obtain a general boundary condition for the Keldysh-Nambu Green's functions at the interface that is valid for arbitrary transparencies of the interface. This allows us to investigate the voltage-dependent conductance (conductance spectrum) of a diffusive normal metal (DN)/ unconventional singlet superconductor junction in both ballistic and diffusive cases. For d-wave superconductor, we calculate conductance spectra numerically for different orientations of the junctions, resistances, Thouless energies in DN, and transparencies of the interface. We demonstrate that conductance spectra exhibit a variety of features including a $V$-shaped gap-like structure, zero bias conductance peak (ZBCP) and zero bias conductance dip (ZBCD). We show that two distinct mechanisms: (i) coherent Andreev reflection (CAR) in DN and (ii) formation of midgap Andreev bound state (MABS) at the interface of d-wave superconductors, are responsible for ZBCP, their relative importance being dependent on the angle $\alpha$ between the interface normal and the crystal axis of d-wave superconductors. For $\alpha=0$, the ZBCP is due to CAR in the junctions of low transparency with small Thouless energies, this is similar to the case of diffusive normal metal / insulator /s-wave superconductor junctions. With increase of $\alpha$ from zero to $\pi/4$, the MABS contribution to ZBCP becomes more prominent and the effect of CAR is gradually suppressed. Such complex spectral features shall be observable in conductance spectra of realistic high-$T_c$ junctions at very low temperature