55 research outputs found
A Neuron-Glial Perspective for Computational Neuroscience
International audienceThere is growing excitement around glial cells, as compelling evidence point to new, previously unimaginable roles for these cells in information processing of the brain, with the potential to affect behavior and higher cognitive functions. Among their many possible functions, glial cells could be involved in practically every aspect of the brain physiology in health and disease. As a result, many investigators in the field welcome the notion of a Neuron-Glial paradigm of brain function, as opposed to Ramon y Cayal's more classical neuronal doctrine which identifies neurons as the prominent, if not the only, cells capable of a signaling role in the brain. The demonstration of a brain-wide Neuron-Glial paradigm however remains elusive and so does the notion of what neuron-glial interactions could be functionally relevant for the brain computational tasks. In this perspective, we present a selection of arguments inspired by available experimental and modeling studies with the aim to provide a biophysical and conceptual platform to computational neuroscience no longer as a mere prerogative of neuronal signaling but rather as the outcome of a complex interaction between neurons and glial cells
Distribution of lipid synthesizing enzymes, 2?,3?-cyclic nucleotide 3?-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development
Immunological evidence for the presence of myelin-related integral proteins in the CNS of hagfish and lamprey
Characterization of Plasmodium yoelii monoclonal antibodies directed against stage-specific sporozoite antigens
Effect of polynucleotides and a basic protein on the condensation of phenylalanyl adenylate
Incorporation of [3H]thymidine into DNA and of [35S]sulfate into sulfatides of oligodendroglial cells during development: Effect of malnutrition
- …