A new thermal vacuum facility at the Martin Marietta Waterton plant

A new thermal-vacuum facility has been recently completed at the Martin Marietta Waterton plant near Denver, Colorado. The facility was designed, fabricated, installed, and tested as a turn-key project by Pitt-Des Moines Inc. and CVI Inc. The chamber has a 5.49 M by 6.10 M (18 ft by 20 ft) flat floor and a half-cylindrical roof with a diameter of 5.49 M (18 ft). Both ends of the chamber have full cross section doors, with one equipped with translating motors for horizontal motion. The chamber is provided with four 0.91 M (36 inches) cryopumps to obtain an ultimate pressure of 9 x 10(exp -8) Torr (Clean-Dry-Empty). The thermal shroud is designed to operate at a maximum of -179 C (-290 F) with an internal heat input of 316 MJ/Hr (300,000 BTU/Hr) using liquid nitrogen. The shroud is also designed to operate at any temperature between -156 C (-250 F) and 121 C (+250 F) using gaseous nitrogen, and heat or cool at a rate of 1.1 C (2 F) per minute

Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3

Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human platelet activation by E. coli leading to thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role in platelet response to various Gram-positive species, its role in activation to Gram-negative bacteria is poorly defined. This study aimed to investigate the molecular mechanisms of human platelet activation by E. coli, including the potential role of FcγRIIA. Using light-transmission aggregometry, measurements of ATP release and tyrosine-phosphorylation, we investigated the ability of two E. coli clinical isolates to activate platelets in plasma, in the presence or absence of specific receptors and signaling inhibitors. Aggregation assays with washed platelets supplemented with IgGs were performed to evaluate the requirement of this plasma component in activation. We found a critical role for the immune receptor FcγRIIA, αIIbβ3, and Src and Syk tyrosine kinases in platelet activation in response to E. coli. IgG and αIIbβ3 engagement was required for FcγRIIA activation. Moreover, feedback mediators adenosine 5’-diphosphate (ADP) and thromboxane A₂ (TxA₂) were essential for platelet aggregation. These findings suggest that human platelet responses to E. coli isolates are similar to those induced by Gram-positive organisms. Our observations support the existence of a central FcγRIIA-mediated pathway by which human platelets respond to both Gram-negative and Gram-positive bacteria

A conceptual modelling framework for Integrated catchment management of salinity

Integrated Catchment Management for salinity is currently a central area of policy concern in Australia. The realisation by politicians and policy makers of the costs and importance of salinity has led to major policy initiatives and spending plans. These focus on the management of catchments as an integrated whole by Catchment Management Boards or Authorities or other bodies depending on State. In New South Wales, the Murray-Darling Basin Commission and the NSW government have initiated a project to support integrated catchment management in the Lachlan and Macquarie catchments (TARGET). This will involve cooperative work by Department of land and Water Conservation (NSW) and the Integrated Catchment Assessment and Management Centre (iCAM) at ANU. iCAM will be responsible for developing a conceptual framework for integrated catchment management involving development of producer profiles, Regional Integrated Management Information Systems and multiperiod models integrating land use, hydrology and salinity management on a land management unit basis within catchments. This paper describes possible modelling approaches to support Integrated Catchment Modelling and presents an outline of the approach planned for TARGET. Future papers will describe progress of the model through to application and regular use in the Lachlan and Macquarie catchments

Full-analytic frequency-domain 1pN-accurate gravitational wave forms from eccentric compact binaries

The article provides ready-to-use 1pN-accurate frequency-domain gravitational wave forms for eccentric nonspinning compact binaries of arbitrary mass ratio including the first post-Newtonian (1pN) point particle corrections to the far-zone gravitational wave amplitude, given in terms of tensor spherical harmonics. The averaged equations for the decay of the eccentricity and growth of radial frequency due to radiation reaction are used to provide stationary phase approximations to the frequency-domain wave forms.Comment: 28 pages, submitted to PR

Probing Unquenching Effects in the Gluon Polarisation in Light Mesons

We introduce an extension to the ladder truncated Bethe-Salpeter equation for mesons and the rainbow truncated quark Dyson-Schwinger equations which includes quark-loop corrections to the gluon propagator. This truncation scheme obeys the axialvector Ward-Takahashi identity relating the quark self-energy and the Bethe-Salpeter kernel. Two different approximations to the Yang-Mills sector are used as input: the first is a sophisticated truncation of the full Yang-Mills Dyson-Schwinger equations, the second is a phenomenologically motivated form. We find that the spectra and decay constants of pseudoscalar and vector mesons are overall described well for either approach. Meson mass results for charge eigenstate vector and pseudoscalar meson masses are compared to lattice data. The effects of unquenching the system are small but not negligible.Comment: 26 pages, 13 figure

Localized spectral asymptotics for boundary value problems and correlation effects in the free Fermi gas in general domains

We rigorously derive explicit formulae for the pair correlation function of the ground state of the free Fermi gas in the thermodynamic limit for general geometries of the macroscopic regions occupied by the particles and arbitrary dimension. As a consequence we also establish the asymptotic validity of the local density approximation for the corresponding exchange energy. At constant density these formulae are universal and do not depend on the geometry of the underlying macroscopic domain. In order to identify the correlation effects in the thermodynamic limit, we prove a local Weyl law for the spectral asymptotics of the Laplacian for certain quantum observables which are themselves dependent on a small parameter under very general boundary conditions

Three-dimensional theory of stimulated Raman scattering

We present a three-dimensional theory of stimulated Raman scattering (SRS) or superradiance. In particular we address how the spatial and temporal properties of the generated SRS beam, or Stokes beam, of radiation depends on the spatial properties of the gain medium. Maxwell equations for the Stokes field operators and of the atomic operators are solved analytically and a correlation function for the Stokes field is derived. In the analysis we identify a superradiating part of the Stokes radiation that exhibit beam characteristics. We show how the intensity in this beam builds up in time and at some point largely dominates the total Stokes radiation of the gain medium. We show how the SRS depends on geometric factors such as the Fresnel number and the optical depth, and that in fact these two factors are the only factors describing the coherent radiation.Comment: 21 pages 14 figure

Underground nuclear power plant siting

This study is part of a larger evaluation of the problems associated with siting nuclear power plants in the next few decades. This evaluation is being undertaken by the Environmental Quality Laboratory of the California Institute of Technology in conjunction with The Aerospace Corporation and several other organizations. Current efforts are directed toward novel approaches to siting plants within the State of California. This report contains the results of efforts performed by The Aerospace Corporation to provide input information to the larger evaluation relative to underground siting of large central station nuclear power plants. Projections of electric power demand in California and the country as a whole suggest that a major increase in generating capacity will be required. The problem is complicated beyond that of a large but straightforward extension of capital investment by increased emphasis on environmental factors combined with the early stage of commercial application and regulation of nuclear power sources. Hydroelectric power generation is limited by the availability of suitable sites, and fossil fueled plants are constrained by the availability of high quality fuels and the adverse environmental and/or economic impact from the use of more plentiful fuels. A substantial increase in the number of nuclear power plants is now under way. This source of power is expected to provide the maj or portion of increased capacity. Other power sources such as geothermal and nuclear fusion are unlikely to satisfy the national needs due to technical problems and the lack of a comprehensive development program. There are several problems associated with meeting the projected power demand. Chief among these is the location of acceptable and economic plant sites. Indeed a sufficient number of sites may not be found unless changes occur in the procedures for selecting sites, the criteria for accepting sites, or the type of site required. Placement of a nuclear plant underground has been suggested as an alternative to present siting practices. It is postulated that the advantages of underground siting in some situations may more than compensate for added costs so that such facilities could be preferred even where surface sites are available. By virtue of greater safety, reduced surface area requirements, and improved aesthetics, underground sites might also be found where acceptable surface sites are not available. Four small European reactors have been constructed partially underground but plans for large size commercial plants have not progressed. Consequently, the features of underground power plant siting are not well understood. Gross physical features such as depth of burial, number and size of excavated galleries, equipment layout, and access or exit shafts/tunnels must be specified. Structural design features of the gallery liners, containment structure, foundations, and gallery interconnections must also be identified. Identification of the nuclear, electrical, and support equipment appropriate to underground operation is needed. Operational features must be defined for normal operations, refueling, and construction. Several magazine articles have been published addressing underground concepts. but adequate engineering data is not available to support an evaluation of the underground concept. There also remain several unresolved questions relative to the advantages of underground siting as well as the costs and other possible penalties associated with this novel approach to siting. These include the degree of increased safety through improved containment; the extent and value of isolation from falling objects, e. g. aircraft; the value of isolation from surface storms and tidal waves; the value of protection from vandalism or sabotage; the extent by which siting constraints are relieved through reduced population-distance requirements or aggravated by underground construction requirements; and the value to be placed upon the aesthetic differences of a less visible facility. The study described in this report has been directed toward some of these questions and uncertainties. Within the study an effort has been made to identify viable configurations and structural liners for typical light water reactor nuclear power plants. Three configurations are summarized in Section 3. A discussion of the underground gallery liner design and associated structural analyses is presented in Section 4. Also addressed in the study and discussed in Section 5 are some aspects of containment for underground plants. There it is suggested that the need for large separations between the plant and population centers may be significantly reduced, or perhaps eliminated. Section 6 contains a brief discussion of operational considerations for underground plants. The costs associated with excavation and lining of the underground galleries have been estimated in Section 7. These estimates include an assessment of variations implied by different seismic loading assumptions and differences in geologic media. It is shown that these costs are a small percentage of the total cost of comparable surface plants. Finally, the parameters characterizing an acceptable underground site are discussed in Section 8. Material is also included in the appendices pertaining to foreign underground plants, span limits of underground excavations, potential siting areas for underground plants in the State of California, pertinent data from the Underground Nuclear Test Program, and other supporting technical discussions