Mobile Sink Node with Discerning Motility Approach for Energy Efficient Delay Sensitive Data Communication over Wireless Sensor Body Area Networks

The sensors nearby the static sink drains their energy resources rapidly, since they continuously involve to build routes in Wireless sensor networks, which are between data sources and static sink. Hence, the sensors nearby the sink having limited lifespan, which axing the network lifetime.The mobile-sink strategy that allows the sink to move around the network area to distribute the transmission overhead to multiple sensor nodes. However, the mobile-sink strategy is often tall ordered practice due to the continuous need of establishing routes between source nodes and the mobile sink (MS) at new position occurred due to its random mobility. In regard to above stated argument, this manuscript proposed a novel energy data transmission strategy which is effective for WSN with mobile sink. Unlike the traditional contributions, which relies on mobile sink with random mobility strategies, the proposal defines a discerning path for mobile sink routing between sectioned clusters of the WSN. The proposal of the manuscript titled “Mobile Sink Node with Discerning Motility Approach (MSDMA) for Energy Efficient Data Communication over WBAN”. The method defined in proposed model sections the target network in to multiple geographical clusters and prioritize these clusters by the delay sensitivity of the data transmitted by the sensor nodes of the corresponding clusters. Further, discriminating these clusters by their delay sensitive priority to define mobile sink route. For estimation of the delay sensitive priority of the clusters, set of metrics are proposed. The experimental study carried on simulation to assess the significance of the suggested method. The performance improvement of the suggested method is ascended through comparative analysis performed against benchmark model under divergent metrics

Ubiquitin‐dependent lysosomal degradation of the HNE‐modified proteins in lens epithelial cells

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154243/1/fsb2fj041743fje.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154243/2/fsb2fj041743fje-sup-0001.pd

Cloud vertical structure over a tropical station obtained using long-term high-resolution radiosonde measurements

Cloud vertical structure, including top and base altitudes, thickness of cloud layers, and the vertical distribution of multilayer clouds, affects large-scale atmosphere circulation by altering gradients in the total diabatic heating and cooling and latent heat release. In this study, long-term (11 years) observations of high-vertical-resolution radiosondes are used to obtain the cloud vertical structure over a tropical station at Gadanki (13.5°&thinsp;N, 79.2°&thinsp;E), India. The detected cloud layers are verified with independent observations using cloud particle sensor (CPS) sonde launched from the same station. High-level clouds account for 69.05&thinsp;%, 58.49&thinsp;%, 55.5&thinsp;%, and 58.6&thinsp;% of all clouds during the pre-monsoon, monsoon, post-monsoon, and winter seasons, respectively. The average cloud base (cloud top) altitudes for low-level, middle-level, high-level, and deep convective clouds are 1.74&thinsp;km (3.16&thinsp;km), 3.59&thinsp;km (5.55&thinsp;km), 8.79&thinsp;km (10.49&thinsp;km), and 1.22&thinsp;km (11.45&thinsp;km), respectively. Single-layer, two-layer, and three-layer clouds account for 40.80&thinsp;%, 30.71&thinsp;%, and 19.68&thinsp;% of all cloud configurations, respectively. Multilayer clouds occurred more frequently during the monsoon with 34.58&thinsp;%. Maximum cloud top altitude and cloud thickness occurred during the monsoon season for single-layer clouds and the uppermost layer of multiple-layer cloud configurations. In multilayer cloud configurations, diurnal variations in the thickness of upper-layer clouds are larger than those of lower-layer clouds. Heating and cooling in the troposphere and lower stratosphere due to these cloud layers are also investigated and peak cooling (peak warming) is found below (above) the cold-point tropopause (CPT) altitude. The magnitude of cooling (warming) increases from single-layer to four- or more-layer cloud occurrence. Further, the vertical structure of clouds is also studied with respect to the arrival date of the Indian summer monsoon over Gadanki.</p

Exploring the Anti-inflammatory and Anti-cancer compounds from the leaves of Acalypha indica

Abstract: Acalypha indica (Euphorbiaceae) is commonly known as Indian Copperleaf and India

STATIC AND TRANSIENT ANALYSIS OF COMPOSITE LEAF SPRING

Leaf springs are mainly used in suspension systems to absorb shock loads in automobiles like light motor vehicles, heavy duty trucks and in rail systems. It carries lateral loads, brake torque, driving torque in addition to shock absorbing. This work deals with finding a suitable composite material that can be a replacement for conventional steel leaf spring. The stress and displacements have been calculated using theoretically as well as using ANSYS for steel leaf spring and composite leaf spring. The model is designed in CREO software for the vehicle Mahindra “Model - commander 650 di”. Analysis is done in ANSYS software for different materials (Steel, Kevlar and E-Glass Epoxy). The static analysis is done to determine the deformation, stress and strain for different materials. A comparative study has been made between steel and composite leaf spring with respect to strength and weight. Transient analysis is done to determine the deformation, stress with respect to time for different materials. Fatigue analysis is done to determine the fatigue life for steel, E glass epoxy and Kevlar leaf spring

A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients

BACKGROUND: Peutz-Jeghers syndrome (PJS) is a rare multi-organ cancer syndrome and understanding its genetic basis may help comprehend the molecular mechanism of familial cancer. A number of germ line mutations in the STK11 gene, encoding a serine threonine kinase have been reported in these patients. However, STK11 mutations do not explain all PJS cases. An earlier study reported absence of STK11 mutations in two Indian families and suggested another potential locus on 19q13.4 in one of them. METHODS: We sequenced the promoter and the coding region including the splice-site junctions of the STK11 gene in 16 affected members from ten well-characterized Indian PJS families with a positive family history. RESULTS: We did not observe any of the reported mutations in the STK11 gene in the index patients from these families. We identified a novel pathogenic mutation (c.790_793 delTTTG) in the STK11 gene in one index patient (10%) and three members of his family. The mutation resulted in a frame-shift leading to premature termination of the STK11 protein at 286(th )codon, disruption of kinase domain and complete loss of C-terminal regulatory domain. Based on these results, we could offer predictive genetic testing, prenatal diagnosis and genetic counselling to other members of the family. CONCLUSION: Ours is the first study reporting the presence of STK11 mutation in Indian PJS patients. It also suggests that reported mutations in the STK11 gene are not responsible for the disease and novel mutations also do not account for many Indian PJS patients. Large-scale genomic deletions in the STK11 gene or another locus may be associated with the PJS phenotype in India and are worth future investigation

Implementation salvage experiences from the Melbourne diabetes prevention study

Background Many public health interventions based on apparently sound evidence from randomised controlled trials encounter difficulties when being scaled up within health systems. Even under the best of circumstances, implementation is exceedingly difficult. In this paper we will describe the implementation salvage experiences from the Melbourne Diabetes Prevention Study, which is a randomised controlled trial of the effectiveness and cost-effectiveness nested in the state-wide Life! Taking Action on Diabetes program in Victoria, Australia.Discussion The Melbourne Diabetes Prevention Study sits within an evolving larger scale implementation project, the Life! program. Changes that occurred during the roll-out of that program had a direct impact on the process of conducting this trial. The issues and methods of recovery the study team encountered were conceptualised using an implementation salvage strategies framework. The specific issues the study team came across included continuity of the state funding for Life! program and structural changes to the Life! program which consisted of adjustments to eligibility criteria, referral processes, structure and content, as well as alternative program delivery for different population groups. Staff turnover, recruitment problems, setting and venue concerns, availability of potential participants and participant characteristics were also identified as evaluation roadblocks. Each issue and corresponding salvage strategy is presented.Summary The experiences of conducting such a novel trial as the preliminary Melbourne Diabetes Prevention Study have been invaluable. The lessons learnt and knowledge gained will inform the future execution of this trial in the coming years. We anticipate that these results will also be beneficial to other researchers conducting similar trials in the public health field. We recommend that researchers openly share their experiences, barriers and challenges when conducting randomised controlled trials and implementation research. We encourage them to describe the factors that may have inhibited or enhanced the desired outcomes so that the academic community can learn and expand the research foundation of implementation salvage.<br /

Miscellaneous Rheumatic Diseases [73-83]: 73. Is There a Delay in Specialist Referral of Hot Swollen Joint?

Background: Patients with acute, hot, swollen joints commonly present to general practitioners, emergency departments and/or acute admitting teams rather than directly to rheumatology. It is imperative to consider septic arthritis in the differential diagnosis of these patients. The British Society of Rheumatology (BSR) has produced guidelines for the management of this condition, which include recommendations for early specialist referral and joint aspiration of all patients with suspected septic arthritis. We examined whether the initial management of patients with acute hot swollen joint(s) at University College London Hospital (UCLH) follows BSR guidelines. Methods: For the period Feb to Nov 2009, appropriate patients were identified by searching the UCLH database using the diagnostic terms, "pyogenic arthritis”, "septic arthritis” and "gout”; and from all joint aspirate requests sent to microbiology. Medical notes were obtained and any patients who had elective arthroscopies or chronic (> 6 weeks) symptoms were excluded. Data were collected on the time taken from the onset of symptoms to specialist (orthopaedic/rheumatology) referral and joint aspiration, collection of blood cultures and antibiotic treatment with or without microbiology advice. Results: Twenty patients were identified with hot swollen (18 monoarticular, 3 prosthetic) joint(s) of < 2 weeks duration. Of whom, 3/20 (15%) were admitted directly to rheumatology, 7/20 (35%) to the acute admissions unit, 3/20 (15%) to orthopaedic, 4/20 (20%) to a medical team and 1/20 (5%) to general surgery. In 19 (95%) cases, specialist (rheumatology/orthopaedic) advice was sought. Of 14 cases not seen directly by specialists 9 (64%) were referred at 24-48 h and 5 (36%) at 48-192 h. All 20 patients had joint aspiration. In 9/20 (45%) of cases, joint aspiration was performed in less than 6 h, 3/20 (15%) cases at 6-24h and 6/20 (30%) cases at 24-192 h and was not recorded in two patients. Of these, crystals were identified in two and one was culture positive. Blood cultures were received for only 6/20 (30%) of cases and only clearly documented to have been taken prior to antibiotic therapy and none were positive. Of 14/20 (70%) started on antibiotic treatment empirically, only 6 (42%) were preceded by joint aspiration. In the 6 patients not treated with antibiotics due to low index of suspicion of septic arthritis, synovial fluid and blood cultures were negative. Microbiology advice was sought in 10/20 (50%) of cases by the admitting teams but the timing of this advice is unclear. Conclusions: Despite the provision of 24 h rheumatology and orthopaedic cover at UCLH, we found a significant delay in acute medical firms seeking specialist advice on the management of patients with acute, hot swollen joints with subsequent deviation from BSR guidelines. Consequently, we plan to increase awareness of these guidelines amongst medical firms at UCLH. Disclosure statement: All authors have declared no conflicts of interes

Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer

BackgroundPatient-derived xenograft (PDX) models involve the engraftment of tumour tissue in immunocompromised mice and represent an important pre-clinical oncology research method. A limitation of non-small cell lung cancer (NSCLC) PDX model derivation in NOD-scid IL2Rgammanull (NSG) mice is that a subset of initial engraftments are of lymphocytic, rather than tumour origin. MethodsThe immunophenotype of lymphoproliferations arising in the lung TRACERx PDX pipeline were characterised. To present the histology data herein, we developed a Python-based tool for generating patient-level pathology overview figures from whole-slide image files; PATHOverview is available on GitHub (https://github.com/EpiCENTR-Lab/PATHOverview).ResultsLymphoproliferations occurred in 17.8% of lung adenocarcinoma and 10% of lung squamous cell carcinoma transplantations, despite none of these patients having a prior or subsequent clinical history of lymphoproliferative disease. Lymphoproliferations were predominantly human CD20+ B cells and had the immunophenotype expected for post-transplantation diffuse large B cell lymphoma with plasma cell features. All lymphoproliferations expressed Epstein-Barr-encoded RNAs (EBER). Analysis of immunoglobulin light chain gene rearrangements in three tumours where multiple tumour regions had resulted in lymphoproliferations suggested that each had independent clonal origins. DiscussionOverall, these data suggest that B cell clones with lymphoproliferative potential are present within primary NSCLC tumours, and that these are under continuous immune surveillance. Since these cells can be expanded following transplantation into NSG mice, our data highlight the value of quality control measures to identify lymphoproliferations within xenograft pipelines and support the incorporation of strategies to minimise lymphoproliferations during the early stages of xenograft establishment pipelines