OH-selected AGB and post-AGB stellar objects II.Blue versus red evolution off the AGB

Using objects found in a systematic survey of the galactic Plane in the 1612-MHz OH line, we discuss in detail two ``sequences'' of post-AGB evolution, a red and a blue. We argue that the red and the blue groups separate by initial mass at 4Msun, based on evolutionary-sequence turn-off colours, spectral energy distributions, outflow velocities and scaleheight. The higher-mass (blue) objects may have earlier AGB termination. The lower-mass (red) objects undergo very sudden reddening for IRAS colour R21\sim1.2; these sources must all undergo a very similar process at AGB termination. The transition colour corresponds to average initial masses of 1.7Msun. A combined IRAS-MSX colour proves a very sensitive tool to distinguish lower-mass, early post-AGB objects from sources still on the AGB and also to distinguish more evolved post-AGB objects from star-forming regions. The high-mass blue objects are the likely precursors of bipolar planetary nebulae, whereas the low-mass red objects will evolve into elliptical planetary nebulae.Comment: 12 pages, LaTex, 7 figures (1 colour), AJ (accepted

OH-selected AGB and post-AGB objects I.Infrared and maser properties

Using 766 compact objects from a survey of the galactic Plane in the 1612-MHz OH line, new light is cast on the infrared properties of evolved stars on the TP-AGB and beyond. The usual mid-infrared selection criteria, based on IRAS colours, largely fail to distinguish early post-AGB stages. A two-colour diagram from narrower-band MSX flux densities, with bimodal distributions, provides a better tool to do the latter. Four mutually consistent selection criteria for OH-masing red PPNe are given, as well as two for early post-AGB masers and one for all post--AGB masers, including the earliest ones. All these criteria miss a group of blue, high-outflow post-AGB sources with 60-mum excess; these will be discussed in detail in Paper II. The majority of post-AGB sources show regular double-peaked spectra in the OH 1612-MHz line, with fairly low outflow velocities, although the fractions of single peaks and irregular spectra may vary with age and mass. The OH flux density shows a fairly regular relation with the stellar flux and the envelope optical depth, with the maser efficiency increasing with IRAS colour R21. The OH flux density is linearly correlated with the 60-mum flux density.Comment: 16 pages, LaTex, 22 figures, AJ (accepted

Veterinary antibiotic usage in the Netherlands in 2010

The objective of this study is to obtain detailed insight into the exposure of farm animals to antibiotics, by monitoring both sales data at the national level and more specifically data per animal species. The results of the study can be used by the Ministry of Economic Affairs, Agriculture and Innovation for policy evaluation. In addition, the usage data might play a role in explaining trends in resistance that have become apparent

The different faces of the macrophage in asthma

PURPOSE OF REVIEW: Asthma is a chronic inflammatory disease in which changes in macrophage polarization have been shown to contribute to the pathogenesis. The present review discusses the contribution of changes in macrophage function to asthma related to polarization changes and elaborates on possible therapeutic strategies targeting macrophage function and polarization. RECENT FINDINGS: Macrophage function alterations were shown to contribute to asthma pathology in several ways. One is by impaired phagocytosis and efferocytosis. Another is by changing inflammation, by altered (anti)inflammatory cytokine production and induction of the inflammasome. Finally, macrophages can contribute to remodeling in asthma, although little evidence is present in humans yet.Novel therapeutic strategies targeting macrophages include dampening inflammation by changing polarization or by inhibiting the NLRP3 inflammasome, and by targeting efferocytosis. However, many of these studies were performed in animal models leaving their translation to the clinic for future research. SUMMARY: The present review emphasizes the contribution of altered macrophage function to asthma, gives insight in possible new therapeutic strategies targeting macrophages, and indicates which knowledge gaps remain open