Principles of development of the transport-transit potential of the primorskiy region

Розглянуто сукупність принципів формування транзитного потенціалу приморських регіонів. Обґрунтовано інструментарій ефективного використання пропускних здібностей морських портів на основі обліку підприємницького ефекту і синергії. Обґрунтовано напрямки підвищення національної складової транзитного потенціалу торгових портів.Рассмотрена совокупность принципов формирования транзитного потенциала приморских регионов. Обосновано инструментарий эффективного использования пропускных способностей морских портов на основе учёта предпринимательского эффекта и синергии. Обоснованы направления повышения национальной составляющей транзитного потенциала торговых портов

Light focusing by silicon nanosphere structures under conditions of magnetic dipole and quadrupole resonances

Metalens is a planar device for light focusing. In this work, we design and optimize c-Si nanosphere metalenses working on the magnetic dipole and quadrupole resonances of the c-Si nanoparticle. Resonant optical response of c-Si nanostructures is simulated by the multipole decomposition method along with the zero-order Born approximation. Limitations of this approach are investigated. The obtained results of optimization are verified by simulation via the T-matrix method

Evolutionary and genetic algorithms for design of metadevices working on electric dipole resonance

All-dielectric nanophotonics is a rapidly growing field of modern science. Metasurfaces and other planar devices based on all-dielectric nanoparticles lead to manage the light propagation at the nanoscale. Impressive effects such as perfect absorption, invisibility, chirality effects, negative refraction, light focusing in the area with size smaller than wavelength, nano-lasing etc - can be achieved with all-dielectric technologies. While it is needed to use more and more complicated designs for solution of modern nanophotonics' currents tasks, non-classical methods of optimization become relevant. For example, to design reconfigurable metalenses with an additional degree of freedom such as polarizability or temperature dependence, evolutionary or genetic algorithms show their high applicability. In this work, we show a new approach to design metalenses with evolutionary and genetic algorithms. © 2020 IOP Publishing Ltd

Polarization Switching Between Electric and Magnetic Quasi-Trapped Modes in Bianisotropic All-Dielectric Metasurfaces

A general strategy for the realization of electric and magnetic quasi-trapped modes located at the same spectral position is presented. This strategy's application makes it possible to design metasurfaces allowing switching between the electric and magnetic quasi-trapped modes by changing the polarization of the incident light wave. The developed strategy is based on two stages: the application of the dipole approximation for determining the conditions required for the implementation of trapped modes at certain spectral positions and the creation of the energy channels for their excitation by introducing a weak bianisotropy in nanoparticles. Since excitation of trapped modes results in a concentration of electric and magnetic energies in the metasurface plane, the polarization switching provides possibilities to change and control the localization and distribution of optical energy at the sub-wavelength scale. A practical method for spectral tuning of quasi-trapped modes in metasurfaces composed of nanoparticles with a preselected shape is demonstrated. As an example, the optical properties of a metasurface composed of silicon triangular prisms are analyzed and discussed

Chronobiological approach to study the physiological activity of <i>Candida</i> species

Rythmometric markers can be identified within a day during the study of biological characteristics in order to be used for differential diagnostics of pathogens of different patients’ physical condition. These principles are based on analysis of clinical isolates С. albicans, С. tropicalis and C. krusei allocated from the vaginal microbiota at Candida dysbiosis condition. Control examples were the master samples from the American Type Culture Collection (ATCC). Detailed research was conducted on physiological characteristics through the formation of biofilms by yeast pathogens. Biological activity of Candida sp. biofilming was observed within 2 days with 4 hours interval in winter. Daily cultures were used for the experiment to correspond to their maximum adhesion to the glass surface. It was important to obtain 6 measurements per day with 3-5 times repetition of experiment conditions during the specified timeline. In order to determine the periodicity of the parameters studied, the data was statistically processed by Student’s t-test, using Mann–Whitney criteria and nonparametric method of least square method.It was found out that biofilming activity during 24 hours (р &lt; 0.05) of fungi exists and that all species have many principles in common. It was attested that the main rhythmometric parameters of diagnostic significance are the rhythm period and amplitude-phase stability. It was found that the daily dynamics of C. albicans 24433 biofilm formation from American Type Culture Collection was characterized by an ultradian (about 12-hours) contribution of the rhythm in the morning – 4 A.M and in the evening – 4 P.M. Significant circadian (approx. daily) rhythms of adhesion glass surface activity were revealed in C. non-albicans from American Type Culture Collection. The dynamic of biofilm formation isolates of yeast from female reproductive organs with Candida pathology was characterized by reliable ultradian (about 12-hour) harmonics which biological significance defines resistance to external impact and the ability to adaptively respond to periodic stimuli.To sum up, implementation of the chronobiological approach has opened up new prospects for studying the physiology of Сandida sp., as it enables us to predict the dynamics of microbial states and takes into account the specificity of emergency and long-term adaptation to different environmental factors. The detection of the circadian rhythm of biofilm formation activity of different Candida sp. strains provides the possibility to manage the vitality of the Society of Bacteria and Fungi and predicts its resistance to various antibiotics

Bioregulation of amplitude-phase biological activity of Candida albicans by women reproductive tract microsymbionts

In this study, we propose a chronobiological method for examining inter-microbial interactions in bacterial and fungal associations in female reproductive tract. Fungal and bacterial species were isolated in 45 women of reproductive aged 19–35, with regular menstrual cycle, applying no hormonal contraceptives, without previous gynecological surgery, abortions, miscarriages with vaginal eubiosis and dysbiosis in history. Sexually transmitted diseases (HIV infection, syphilis, gonorrhea, trichomoniasis, chlamydiosis) were excluded in all subjects. Proliferation rate, morphogenesis and phospholipase activity were examined within the 48-hour period every 4 hours, in winter time, Moon phase IV. The data obtained were assessed by using Student’s t-test, Wilcoxon test, and least squares method. All subjects were divided into the groups: group 1 — women with vaginal eubiosis, group 2 — women with vaginal dysbiosis. It was shown that in all subjects experimental parameters of C. albicans cultures showed a diurnal dynamics characterized in healthy women by circadian rhythms with a single peak of activity. However, in women with vaginal dysbiosis C. albicans was characterized by significant ultradian (around 12 hours long) rhythms with two peaks of biological activity. Concurrence and consistency in manifested physiological functions related to clinical isolates was coupled to temporal pattern of distributed biological resources in fungi depending on course of infectious process. It was found that in vaginal eubiosis exometabolites released by dominant associated microbiota did not significantly change microbiota-related amplitude-phase parameters. The data obtained evidenced that temporal pattern of parameters related to C. albicans from healthy individuals was stable and independent on bacterial metabolites. In contrast, dominant microsymbiont in vaginal dysbiosis inhibited fungi-related rhythms, which might be important in establishing lactobacillus-associated biotope colonization resistance. Effects of metabolites released by the associated microbiota typical to dysbiosis was revealed by increased mesor, amplitude, preserved biorhythm spectral pattern in examined properties as well as amplitude-phase characteristics indicating at enhanced or sustained C. albicans adaptive potential. Therefore, the amplitude-phase parameter of C. albicans physiological activity served as a marker of opposite (enhanced/weakened) effect of microsymbiont survival described in “microbial dominant-associate” pairs

The first notes on taxonomic diversity of leaf-mining micromoths, Gracillariidae (Insecta, Lepidoptera) in Omskaya Oblast, Russia

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Скрининг латентной туберкулезной инфекции с применением аллергена туберкулезного рекомбинантного

In recent years the significant deterioration of health has been observed in schoolchildren. As per official data only 20% of children graduating from school are considered to be completely healthy, and 60% suffer from chronic diseases, i.e. belong to health groups III, IV and V, among which there are many children belonging to tuberculosis risk groups and suffering from undetected latent tuberculous infection. The efficiency of the new technique aimed to detect active tuberculous infection in children and adolescents of health groups III, IV and V has been evaluated. Screening proved the reduction in the number of patients in need of TB doctor advising by 8.4 fold compared to traditional mass diagnostics with tuberculin. Hyperergic reactions to diaskintest are 6 fold less common compared to Mantoux test. And 99.2% of children referred to TB doctor were registered to the dispensary follow-up versus 23.4% of children referred to TB doctor as per mass tuberculin testing results. (p &lt; 0.001). Thus the validity of referral to TB doctor increased 4.2 fold. The detection rate of active forms of tuberculosis made 0.4 per 1000 examinations versus 0.1 in case of mass screening with tuberculin testing.В последние годы наблюдается существенное ухудшение состояния здоровья школьников. По официальным данным, лишь 20% детей, заканчивающих школу, считаются полностью здоровыми, а 60% имеют хронические заболеваниями, т. е. III, IV или V группу здоровья, среди которых велика доля детей, относящихся к группам риска по туберкулезу и имеющих невыявленную латентную туберкулезную инфекцию. Проведена оценка эффективности нового метода выявления активной туберкулезной инфекции у детей и подростков III, IV и V групп здоровья. Скрининговое исследование показало уменьшение числа пациентов, нуждающихся в консультации фтизиатра, в 8,4 раза по сравнению с традиционной массовой туберкулинодиагностикой. Гиперергические реакции на пробу с диаскинтестом выявляются в 6 раз реже по сравнению с пробой Манту. При этом на диспансерный учет у врача-фтизиатра взято 99,2% детей от направленных на консультацию против 23,4% детей, направленных по результатам массовой туберкулинодиагностики (p &lt; 0,001). Таким образом, в 4,2 раза увеличилась обоснованность направления ребенка к врачу-фтизиатру. Выявляемость активных форм туберкулеза новым методом составила 0,4 на 1 000 обследованных против 0,1 при проведении массовой традиционной туберкулинодиагностики

Скрининг детей и подростков на туберкулезную инфекцию в России – прошлое, настоящее, будущее

The article presents a brief overview of the establishment and development of screening system in the pediatric population for tuberculosis and latent tuberculosis infection - from Koch alt-tuberculin to modern recombinant tuberculosis allergens for intradermal administration and in vitro laboratory tests. It gives extensive data on clinical research and the introduction into practical public health of the Russian Federation of the test with recombinant tuberculosis allergen as a screening method for tuberculosis in children from 8 to 14 years old inclusively.Представлен краткий обзор становления и развития системы скрининга детского населения на туберкулез и на латентную туберкулезную инфекцию – от альт-туберкулина Коха до современных рекомбинантных аллергенов туберкулезных для внутрикожного введения и лабораторных тестов in vitro. Приведены обширные данные о клиническом исследовании и внедрении в практическое здравоохранение РФ пробы с аллергеном туберкулезным рекомбинантным в качестве скрининга на туберкулез у детей с 8 до 14 лет включительно