On the global uniform stability analysis of non-autonomous dynamical systems: A survey

In this survey, we introduce the notion of stability of time varying nonlinear systems. In particular we investigate the notion of global practical exponential stability for non-autonomous systems. The proposed approach for stability analysis is based on the determination of the bounds of perturbations that characterize the asymptotic convergence of the solutions to a closed ball centered at the origin

safety and efficacy of trifluridine tipiracil ftd tpi in metastatic colorectal cancer mcrc patients according to previous treatment with regorafenib in the international phase iiib preconnect study

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p 167symptoms reported at initial diagnosis of metastatic pancreatic adenocarcinoma m pac in routine clinical practice and variation in frequencies across europe

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pd 004baseline characteristics and second line treatment for metastatic pancreatic adenocarcinoma mpac patients receiving first line folfirinox gemcitabine nab paclitaxel or gemcitabine monotherapy in routine clinical practice across europe

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canstem303c trial a phase 3 study of napabucasin napa in combination with 5 fluorouracil 5 fu leucovorin and irinotecan folfiri in adult patients pts with previously treated metastatic colorectal cancer mcrc trial in progress

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o 013safety and efficacy of trifluridine tipiracil in previously treated metastatic colorectal cancer mcrc preliminary results from the phase iiib international open label early access preconnect study

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Sebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applications

Background: “Residual skin surface components” (RSSC) is the collective term used for the superficial layer of sebum, residue of sweat, small quantities of intercellular lipids and components of natural moisturising factor present on the skin surface. Potential applications of RSSC include use as a sampling matrix for identifying biomarkers of disease, environmental exposure monitoring, and forensics (retrospective identification of exposure to toxic chemicals). However, it is essential to first define the composition of “normal” RSSC. Therefore, the aim of the current study was to characterise RSSC to determine commonalities and differences in RSSC composition in relation to sex and ethnicity. Methods: Samples of RSSC were acquired from volunteers using a previously validated method and analysed by high-pressure liquid chromatography–atmospheric pressure chemical ionisation–mass spectrometry (HPLC-APCI-MS). The resulting data underwent sebomic analysis. Results: The composition and abundance of RSSC components varied according to sex and ethnicity. The normalised abundance of free fatty acids, wax esters, diglycerides and triglycerides was significantly higher in males than females. Ethnicity-specific differences were observed in free fatty acids and a diglyceride. Conclusions: The HPLC-APCI-MS method developed in this study was successfully used to analyse the normal composition of RSSC. Compositional differences in the RSSC can be attributed to sex and ethnicity and may reflect underlying factors such as diet, hormonal levels and enzyme expression.Peer reviewedFinal Published versio