Wound healing activity of topical phenytoin in excision wound model of Albino rats

Background: Wound healing is a major medical entity. Phenytoin being an anticonvulsant drug has shown promising results in healing chronic wounds. In the present study we have evaluated the effect of topical Phenytoin on excision wound models of albino rats.Methods: Phenytoin ointment of 1%, 5% and 10% were used topically on experimental animals. Neomycin used as reference standard. In Excision wound model period of epithelialization, area of wound and hydroxyproline content were evaluated.Results: Phenytoin 1%, 5% and 10% have shown significant (P<0.001) wound healing property compared to control and Neomycin. Phenytoin hastened the wound healing compared to control and neomycin and increased hydroxyproline content of wound. Phenytoin 5% has better wound healing property compared to 1% and 10%.Conclusions: The present study has shown that Phenytoin reduces time for wound healing and improved the quality of healing tissue which provides rationale for use in chronic wound in clinical setting

Multifactor Authentication Key Management System based Security Model Using Effective Handover Tunnel with IPV6

In the current modern world, the way of life style is being completely changed due to the emerging technologies which are reflected in treating the patients too. As there is a tremendous growth in population, the existing e-Healthcare methods are not efficient enough to deal with numerous medical data. There is a delay in caring of patient health as communication networks are poor in quality and moreover smart medical resources are lacking and hence severe causes are experienced in the health of patient. However, authentication is considered as a major challenge ensuring that the illegal participants are not permitted to access the medical data present in cloud. To provide security, the authentication factors required are smart card, password and biometrics. Several approaches based on these are authentication factors are presented for e-Health clouds so far. But mostly serious security defects are experienced with these protocols and even the computation and communication overheads are high. Thus, keeping in mind all these challenges, a novel Multifactor Key management-based authentication by Tunnel IPv6 (MKMA- TIPv6) protocol is introduced for e-Health cloud which prevents main attacks like user anonymity, guessing offline password, impersonation, and stealing smart cards. From the analysis, it is proved that this protocol is effective than the existing ones such as Pair Hand (PH), Linear Combination Authentication Protocol (LCAP), Robust Elliptic Curve Cryptography-based Three factor Authentication (RECCTA) in terms storage cost, Encryption time, Decryption time, computation cost, energy consumption and speed. Hence, the proposed MKMA- TIPv6 achieves 35bits of storage cost, 60sec of encryption time, 50sec decryption time, 45sec computational cost, 50% of energy consumption and 80% speed

DESIGN OF FIR FILTER USING LOOK UP TABLE AND MEMORY BASED APPROACH

The main objective of this Paper is to develop Finite Impulse Response (FIR) Filter using look-up table (LUT) and memory based processor. The configuration is to reduce memory size, logic gate count and improve the speed of operation. Digital filters are becoming ubiquitous in audio applications. As a result, good digital filter performance is important to audio system design. Digital filters differ from conventional analog filters by their use of finite precision to represent signals and coefficients and finite precision arithmetic to compute the filter response. In this Paper, FIR filter is implemented in Xilinx ise using VHDL language. VHDL coding for the FIR filter is implemented in this Paper and waveforms are observed through simulation

Comparative study of oral PGE 1 and intracervical PGE2 gel for pre-induction cervical ripening in prelabour rupture of membranes >37 weeks gestational age

Background: Active induction of labour in prelabour rupture of membranes resulted in a lower risk of maternal and fetal sepsis as compared to conservative management. Pre-induction cervical ripening helps in successful induction of labour.in this study we have compared the efficacy of low dose 25 mcg oral misoprostol versus intracervical PGE2 gel for cervical ripening in term PROM patients.Methods: Women with pregnancies between 37 and 41 weeks gestational age presenting with PROM at term and a Bishop score of 4 or less were randomly assigned to receive either a 25-mcg oral misoprostol every 4-hourly interval or 3 applications of intracervical PGE2 gel at a 6-hour interval for effective cervical ripening. Oxytocin was initiated if labor had not started after 6 hours of last effective dose of prostaglandin.Results: Fifty-three women (75.73%) (n = 70) in the oral misoprostol group with 2 doses, 4 hours apart had successful cervical ripening within 8 hours in comparison to sixty-two women (88.58%) (n = 70) in the intracervical PGE2 gel group with 2 doses, 6 hrs apart approximately 12 hrs for successful ripening. (p = 0.021). Oral misoprostol group needed shorter mean duration interval for the Bishop score 6 than intracervical PGE2 gel group, 7.84±3.64 hours and 9.39±4.20 hours respectively (p = 0.022). Similarly, the mean time duration interval from ruptured membranes to vaginal delivery in oral misoprostol was shorter i.e. 12.60±3.78 hours versus 14.66±4.08 hours (p = 0.005).Conclusions: Low dose 25 mcg oral misoprostol is a safe, efficacious and better tolerated alternative to intracervical PGE2 gel for pre-induction cervical ripening in especially in PROM patients at term

Techniques Used in Biometric Authentication - Applicability and Future Scope

In recent past, biometrics has emerged rapidly with its worldwide applications for daily living. Novel trends and new developments have been proposed to obtain and pursue many diverse biometric traits. The ignored challenge in the precedent and potential issues need to be addressed together and intensely integrated. The main objective of the paper is to keep up with the innovative technologies on some current theoretical development as well as fresh trends of biometric applications. The topics covered in this paper reflect well both aspects of development. This paper deals with the techniques used for biometric authentication and their future possibilities. This paper also focus on the applicability, strengths and weaknesses of several biometric recognition systems with a comprehensive review of the developments in this field

A DCM Based PFC CUK Converter-Speed Adjustable BLDC Drive

This paper proposes a DCM based PFC cuk converter-speed adjustable BLDC drive. This system has major advantages like: it is a money-making solution for low-power applications and it operates in discontinuous conduction mode also. The speed of the BLDC motor is controlled by dc-bus voltage of a voltage source inverter (VSI). VSI uses a low switching frequency to reduce the switching losses. A diode bridge rectifier followed by a Cuk converter functioning in a discontinuous conduction mode (DCM) is used for control of dc-link voltage. And also it will keep unity power factor at ac mains. Performance of the PFC Cuk converter is evaluated under four different operating conditions of discontinuous and continuous conduction modes (CCM). The performance of the proposed system is simulated in MATLAB/Simulink environment to validate its performance over a wide range of speed with unity power factor at ac mains

A new interline DVR with displacement factor improvement using fuzzy logic controller for voltage unbalance condition

A new interline dvr with displacement factor improvement using fuzzy logic controller for voltage sags and swells condition have been designed. Generally interline dynamic voltage restorer (IDVR) is employed in distribution systems to mitigates voltage sag and swell problems. An IDVR consists of several dynamic voltage restorers (DVRs) sharing a common dc link connecting independent feeders. One of the DVRs compensates for the local voltage sag in its feeder; the other DVRs replenish the common dc-link voltage. For normal voltage levels, the DVRs should be bypassed or un-operated. Generally instead of bypassing the DVRs, this paper proposes a new operating technique to improve the displacement factor (DF) of one of the involved feeders. DF improvement can be achieved via active and reactive power exchange between two different feeders. The fuzzy logic controller improves the performance and reduces the total harmonic distortion. Simulation results can be shown the performance of proposed converter using MATLAB software

A NOVEL APPROACH OF LOCUST BEAN GUM MICROSPHERES FOR COLONIC DELIVERY OF MESALAMINE

Objective: The objective of the present study was to formulate site-specific drug delivery of mesalamine using Locust bean gum.Methods: The core microspheres were prepared by ionic gelation method using CaCl2 solution and cross-linked with glutaraldehyde and were further coated with pH-sensitive polymer eudragit S-100(1.5-4.5 ml) to retard the drug release in the upper gastrointestinal environment (Stomach and small intestine). Microspheres were characterized by ftir spectroscopy, differential scanning calorimetry and evaluated by scanning electron microscopy (SEM), particle size analysis, entrapment efficiency and in vitro drug release studies in different simulated gastric fluids. Stability studies were carried out for one month at 40±2 °C/75±5% RH.Results: The SEM images revealed the surface morphology was rough and smooth for core and coated microspheres, respectively. The optimized batch (ILBG6) of core microspheres(for 7hr), coated microspheres and coated microspheres in presence of rat caecal contents (8%w/v) for 24hr exhibited 98.44±2.48, 73.58±3.49 % and 98.28±4.42 drug release, respectively. The drug release from all locust bean gum microsphere formulations followed higuchi kinetics. Moreover, drug release from Eudragit S-100 coated microspheres followed the korsmeyer-peppas equation with an fickian kinetics mechanism. Finally, stability studies suggested the change in entrapment efficiency and in vitro drug release of microspheres was minimal, indicating good stability of the formulation.Conclusion: The microspheres formed using natural polysaccharide locust beangum by ionic gelation method are capable of colon targeting the anti-inflammatory drug, mesalamine for the treatment of ulcerative colitis